Výsledky vyhledávání - "Basri Gülbakan"

An investigation of different intracellular parameters for Inborn Errors of Metabolism: Cellular stress, antioxidant response and autophagy

Autor: Neşe Vardar Acar, Ali Dursun, Damla Aygün, H. Esra Gürses Cila, İncilay Lay, Basri Gülbakan, R.Köksal Özgül

Publikováno v: Free radical biologymedicine. 179

Oxidative stress is associated with various disease pathologies including Inborn Errors of Metabolism (IEMs), among the most important causes of childhood morbidity and mortality. At least as much as oxidative stress in cells, reductive stress poses

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896f2bc49349538c29263d2f0b8a57d6
https://pubmed.ncbi.nlm.nih.gov/34974126

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Biallelic mutations in ELFN1 gene associated with developmental and epileptic encephalopathy and joint laxity

Autor: Yilmaz Yildiz, Can Kosukcu, Kader Karli Oguz, Ceren Günbey, Neşe Vardar Acar, Dilek Yalnizoglu, Ali Dursun, Halil Tuna Akar, Basri Gülbakan, Didem Yücel Yılmaz, R. Köksal Özgül, Ayça Burcu Kahraman

Publikováno v: European Journal of Medical Genetics. 64:104340

ELFN1, a transmembrane leucine rich repeat protein, is involved in signal transduction in both neural cells and ROD ON-bipolar synaptogenesis. We present three siblings with developmental and epileptic encephalopathy and co-morbidities due to ELFN1 g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a48d0ea050afd4ce2ebe34a16e53d97e
https://doi.org/10.1016/j.ejmg.2021.104340

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Applying mass spectrometry to study non-covalent biomolecule complexes

Autor: Alfredo J. Ibáñez, Stephan R. Fagerer, Fan Chen, Simon Weidmann, Renato Zenobi, Basri Gülbakan

Publikováno v: Mass Spectrometry Reviews. 35:48-70

Non-covalent interactions are essential for the structural organization of biomacromolecules and play an important role in molecular recognition processes, such as the interactions between proteins, glycans, lipids, DNA, and RNA. Mass spectrometry (M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6069cda2a3d86e72d96ee6e28ad68d05
https://doi.org/10.1002/mas.21462

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Determination of thermodynamic and kinetic properties of biomolecules by mass spectrometry

Autor: Konstantin Barylyuk, Basri Gülbakan, Renato Zenobi

Publikováno v: Current opinion in biotechnology

Over the past two decades, mass spectrometry (MS) has transformed the life sciences. The advances in understanding biomolecule structure and function by MS is progressing at an accelerated pace. MS has also largely been applied to study thermodynamic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::356b024a5cbc59febd8b1f940a5e9313

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Oligonucleotide aptamers: emerging affinity probes for bioanalytical mass spectrometry and biomarker discovery

Autor: Basri Gülbakan

Publikováno v: Analytical Methods. 7:7416-7430

Selective isolation of biologically important molecules and their functional characterization is one of the primary goals of bioanalytical chemistry. Several different affinity tools such as antibodies, affimers, nanobodies, and DARPins have been exp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c086a53bcc79302fb3b5da74474f54e6
https://doi.org/10.1039/c5ay00650c

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DNA oligonucleotides: a model system with tunable binding strength to study monomer-dimer equilibria with electrospray ionization-mass spectrometry

Autor: Konstantin Barylyuk, Basri Gülbakan, Renato Zenobi, Xueshu Xie

Publikováno v: Analytical chemistry

Electrospray ionization (ESI) is increasingly used to measure binding strengths, but it is not always clear whether the ESI process introduces artifacts. Here we propose a model monomer-dimer equilibrium system based on DNA oligonucleotides to system

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a150ad72efc8b89940e553fce1891c03

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Discovery of biomarkers in rare diseases: Innovative approaches by predictive and personalized medicine

Autor: Matthias Kohl, Rıza Köksal Özgül, Ayse Yuzbasioglu, Basri Gülbakan, Hans-Peter Deigner, Meral Özgüç

Publikováno v: The EPMA Journal

There are more than 8000 rare diseases (RDs) that affect >5 % of the world's population. Many of the RDs have no effective treatment and lack of knowledge creates delayed diagnosis making management difficult. The emerging concept of the personalized

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::644e9559a7ce423a626fca5b115b9c10
https://publica.fraunhofer.de/handle/publica/248538

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Generation of Fluorogen-Activating Designed Ankyrin Repeat Proteins (FADAs) as Versatile Sensor Tools

Autor: Alexander Batyuk, Renato Zenobi, Yufan Wu, Basri Gülbakan, Lutz Kummer, Christoph Klenk, K. Dane Wittrup, Peer R. E. Mittl, Seymour de Picciotto, Erik Sedlák, Andreas Plückthun, Franziska Zosel, Jendrik Schöppe, Marco Schütz, Gregory A. Newby

Publikováno v: Journal of Molecular Biology

Fluorescent probes constitute a valuable toolbox to address a variety of biological questions and they have become irreplaceable for imaging methods. Commonly, such probes consist of fluorescent proteins or small organic fluorophores coupled to biolo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::691551db2b9475d1809a59ec03ff73b5
https://pubmed.ncbi.nlm.nih.gov/26812208

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