Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension

Autor: Hebah A. Sindi, Giusy Russomanno, Sandro Satta, Vahitha B. Abdul-Salam, Kyeong Beom Jo, Basma Qazi-Chaudhry, Alexander J. Ainscough, Robert Szulcek, Harm Jan Bogaard, Claire C. Morgan, Soni S. Pullamsetti, Mai M. Alzaydi, Christopher J. Rhodes, Roberto Piva, Christina A. Eichstaedt, Ekkehard Grünig, Martin R. Wilkins, Beata Wojciak-Stothard

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)

Pulmonary arterial hypertension is a severe lung disease characterised by progressive vascular remodelling. Here, the authors show that reduced signalling of flow-activated transcription factor KLF2 is a common feature of human PAH and that KLF2-regu

Externí odkaz: https://doaj.org/article/4eebb969beec4b25a1d7906be6c74e47

Structural investigations into colour-tuneable fluorescent InZnP-based quantum dots from zinc carboxylate and aminophosphine precursors

Autor: Mary Burkitt-Gray, Marianna Casavola, Pip C. J. Clark, Simon M. Fairclough, Wendy R. Flavell, Roland A. Fleck, Sarah J. Haigh, Jack Chun-Ren Ke, Marina Leontiadou, Edward A. Lewis, Jacek Osiecki, Basma Qazi-Chaudhry, Gema Vizcay-Barrena, Wijittra Wichiansee, Mark Green

Publikováno v: Burkitt-Gray, M, Casavola, M, Clark, P C J, Fairclough, S M, Flavell, W, Fleck, R A, Haigh, S, Ke, J C-R, Leontiadou, M, Lewis, E, Osiecki, J, Qazi-Chaudry, B, Vizcay-Barrena, G, Wichiansee, W & Green, M 2022, ' Structural investigations into colour-tuneable fluorescent InZnP-based quantum dots from zinc carboxylate and aminophosphine precursors ', Nanoscale . https://doi.org/10.1039/D2NR02803D

Fluorescent InP-based quantum dots have emerged as valuable nanomaterials for display technologies, biological imaging, and optoelectronic applications. The inclusion of zinc can enhance both their emissive and structural properties and reduce interf

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::844c713ff06a94ebab6e97e2e619a020
https://research.manchester.ac.uk/en/publications/03ab6ecf-2e11-4a28-b71f-333f8c7216fa

Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension

Autor: Sandro Satta, Christopher J. Rhodes, Kyeong Beom Jo, Hebah A. Sindi, Martin R. Wilkins, Mai M. Alzaydi, Alexander J. Ainscough, Basma Qazi-Chaudhry, Harm Jan Bogaard, Giusy Russomanno, Beata Wojciak-Stothard, Soni Savai Pullamsetti, Robert Szulcek, Claire Morgan, Roberto Piva, Christina A. Eichstaedt, Ekkehard Grünig, Vahitha B. Abdul-Salam

Publikováno v: Nature Communications, 11(1):1185. Nature Publishing Group UK
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
NATURE COMMUNICATIONS
Sindi, H A, Russomanno, G, Satta, S, Abdul-Salam, V B, Jo, K B, Qazi-Chaudhry, B, Ainscough, A J, Szulcek, R, Jan Bogaard, H, Morgan, C C, Pullamsetti, S S, Alzaydi, M M, Rhodes, C J, Piva, R, Eichstaedt, C A, Grünig, E, Wilkins, M R & Wojciak-Stothard, B 2020, ' Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension ', Nature Communications, vol. 11, no. 1, 1185 . https://doi.org/10.1038/s41467-020-14966-x
Nature Communications

Pulmonary arterial hypertension (PAH) is a severe disorder of lung vasculature that causes right heart failure. Homoeostatic effects of flow-activated transcription factor Krüppel-like factor 2 (KLF2) are compromised in PAH. Here, we show that KLF2-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff2d0f7a264a7a3a9a16f23e72f3402b
https://research.vumc.nl/en/publications/049dd2cd-5692-4828-b334-1f78c2e52991