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Autor:
Bryce V. Plapp, Jon K. Rubach, Baskar Raj Savarimuthu, Eric N. Brown, S. Ramaswamy, Daniel J. Ferraro
Publikováno v:
'Biochemistry ', vol: 56, pages: 3632-3646 (2017)
Biochemistry
Biochemistry
During catalysis by liver alcohol dehydrogenase (ADH), a water bound to the catalytic zinc is replaced by the oxygen of the substrates. The mechanism might involve a pentacoordinated zinc or a double-displacement reaction with participation by a near