Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Baskar Bakthavachalu"'
Publikováno v:
PLoS Biology, Vol 21, Iss 10, p e3002342 (2023)
Upon water loss, some organisms pause their life cycles and escape death. While widespread in microbes, this is less common in animals. Aedes mosquitoes are vectors for viral diseases. Aedes eggs can survive dry environments, but molecular and cellul
Externí odkaz:
https://doaj.org/article/07c31e3d908e40a4b7c32ea30e40b51a
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 11, Iss 12 (2021)
AbstractThe Ataxin-2 (Atx2) protein contributes to the progression of neurodegenerative phenotypes in animal models of amyotrophic lateral sclerosis (ALS), type 2 spinocerebellar ataxia (SCA-2), Parkinson’s disease, and Huntington’s disease (HD).
Externí odkaz:
https://doaj.org/article/0e73e773da5a4881a03609f24718058e
Autor:
Amanjot Singh, Joern Hulsmeier, Arvind Reddy Kandi, Sai Shruti Pothapragada, Jens Hillebrand, Arnas Petrauskas, Khushboo Agrawal, Krishnan RT, Devasena Thiagarajan, Deepa Jayaprakashappa, K VijayRaghavan, Mani Ramaswami, Baskar Bakthavachalu
Publikováno v:
eLife, Vol 10 (2021)
Ataxin-2 (Atx2) is a translational control molecule mutated in spinocerebellar ataxia type II and amyotrophic lateral sclerosis. While intrinsically disordered domains (IDRs) of Atx2 facilitate mRNP condensation into granules, how IDRs work with stru
Externí odkaz:
https://doaj.org/article/428c6a3a30a84321ad3d7b141ac0f928
Autor:
Chandrama Mukherjee, Deepak P. Patil, Brian A. Kennedy, Baskar Bakthavachalu, Ralf Bundschuh, Daniel R. Schoenberg
Publikováno v:
Cell Reports, Vol 2, Iss 3, Pp 674-684 (2012)
The notion that decapping leads irreversibly to messenger RNA (mRNA) decay was contradicted by the identification of capped transcripts missing portions of their 5′ ends and a cytoplasmic complex that can restore the cap on uncapped mRNAs. In this
Externí odkaz:
https://doaj.org/article/13c7f21605684bf19e86d3c6eb3f1a44
Publikováno v:
PLoS Biology, Vol 12, Iss 8, p e1001933 (2014)
Cytoplasmic capping is catalyzed by a complex that contains capping enzyme (CE) and a kinase that converts RNA with a 5'-monophosphate end to a 5' diphosphate for subsequent addition of guanylic acid (GMP). We identify the proline-rich C-terminus as
Externí odkaz:
https://doaj.org/article/c17cb860da79497a84478ae22e53deb2
Upon extreme water loss, some organisms pause their life cycles and escape death, in a process called anhydrobiosis. While widespread in microbes, this is uncommon in animals. Mosquitoes of theAedesgenus are vectors for several viral diseases in huma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e118c43fe8c25a8b29dd8ab5413c21e
https://doi.org/10.1101/2022.12.30.522323
https://doi.org/10.1101/2022.12.30.522323
Autor:
Amanjot Singh, Arvind Reddy Kandi, Deepa Jayaprakashappa, Guillaume Thuery, Devam J. Purohit, Joern Huelsmeier, Rashi Singh, Sai Shruti Pothapragada, Mani Ramaswami, Baskar Bakthavachalu
Publikováno v:
Molecular Biology of the Cell. 33
Cells respond to stress with translational arrest, robust transcriptional changes, and transcription-independent formation of mRNP assemblies termed stress granules (SGs). Despite considerable interest in the role of SGs in oxidative, unfolded protei
Autor:
Arnas Petrauskas, Daniel L. Fortunati, Amanjot Singh, Arvind Reddy Kandi, Sai Shruti Pothapragada, Khushboo Agrawal, Joern Huelsmeier, Jens Hillebrand, Georgia Brown, Dhananjay Chaturvedi, Jongbo Lee, Chunghun Lim, Georg Auburger, K. VijayRaghavan, Mani Ramaswami, Baskar Bakthavachalu
Ataxin-2 (ATXN2) is a gene implicated in spinocerebellar ataxia type II (SCA2), amyotrophic lateral sclerosis (ALS) and Parkinsonism. The encoded protein is a therapeutic target for ALS and related conditions. ATXN2 (or Atx2 in insects) can function
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fc5f52de3bee1ac05606bdeb051033e
https://doi.org/10.1101/2022.02.15.480566
https://doi.org/10.1101/2022.02.15.480566
Publikováno v:
G3: Genes|Genomes|Genetics
G3: Genes, Genomes, Genetics, Vol 11, Iss 12 (2021)
G3: Genes, Genomes, Genetics, Vol 11, Iss 12 (2021)
The Ataxin-2 (Atx2) protein contributes to the progression of neurodegenerative phenotypes in animal models of amyotrophic lateral sclerosis (ALS), type 2 spinocerebellar ataxia (SCA-2), Parkinson’s disease, and Huntington’s disease (HD). However