Rational design, synthesis, biological evaluation, molecular docking, and molecular dynamics of substituted uracil derivatives as potent anti-cancer agents.

Autor: Basiony EA; Department of Chemistry, Faculty of Science, Menoufia University, Egypt; Department of Photochemistry (Synthetic Unit), Chemical Industries Research Institute, National Research Centre, Cairo 12622, Egypt., Hassan AA; Department of Chemistry, Faculty of Science, Suez University, Suez 43221, Egypt., Elsawalhy M; Department of Chemistry, Faculty of Science, Menoufia University, Egypt., Abdel-Rahman AA; Department of Chemistry, Faculty of Science, Menoufia University, Egypt., Mansour H; Department of Cell Biology, Biotechnology Research Institute, National Research Centre, Cairo 12622, Egypt., Arafa RK; Drug Design and Discovery Lab, Zewail City of Science and Technology, Cairo 12578, Egypt; Biomedical Sciences Program, University of Science and Technology, Zewail City of Science and Technology, Cairo 12578, Egypt. Electronic address: rkhidr@zewailcity.edu.eg., Hassan NA; Department of Photochemistry (Synthetic Unit), Chemical Industries Research Institute, National Research Centre, Cairo 12622, Egypt. Electronic address: nasserabdelhamid@hotmail.com.

Publikováno v: Bioorganic chemistry [Bioorg Chem] 2024 Dec 17; Vol. 154, pp. 108066. Date of Electronic Publication: 2024 Dec 17.