Beneficial effects of RAF inhibitor in mutant BRAF splice variant-expressing melanoma.

Autor: Hartsough EJ; Authors' Affiliations: Departments of Cancer Biology and 2Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania., Basile KJ, Aplin AE

Publikováno v: Molecular cancer research : MCR [Mol Cancer Res] 2014 May; Vol. 12 (5), pp. 795-802. Date of Electronic Publication: 2014 Feb 11.

Genetic susceptibility to type 2 diabetes and obesity: follow-up of findings from genome-wide association studies.

Autor: Basile KJ; Division of Human Genetics, The Children's Hospital of Philadelphia Research Institute, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA., Johnson ME; Division of Human Genetics, The Children's Hospital of Philadelphia Research Institute, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA., Xia Q; Division of Human Genetics, The Children's Hospital of Philadelphia Research Institute, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA., Grant SF; Division of Human Genetics, The Children's Hospital of Philadelphia Research Institute, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA ; Center for Applied Genomics, The Children's Hospital of Philadelphia Research Institute, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA ; Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA ; 1216F Children's Hospital of Philadelphia Research Institute, 34th and Civic Center Boulevard, Philadelphia, PA 19104, USA.

Publikováno v: International journal of endocrinology [Int J Endocrinol] 2014; Vol. 2014, pp. 769671. Date of Electronic Publication: 2014 Feb 25.

In vivo MAPK reporting reveals the heterogeneity in tumoral selection of resistance to RAF inhibitors.

Autor: Basile KJ; Authors' Affiliations: Departments of Cancer Biology, Medical Oncology, and Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania., Abel EV, Dadpey N, Hartsough EJ, Fortina P, Aplin AE

Publikováno v: Cancer research [Cancer Res] 2013 Dec 01; Vol. 73 (23), pp. 7101-10. Date of Electronic Publication: 2013 Oct 11.

TWIST1 is an ERK1/2 effector that promotes invasion and regulates MMP-1 expression in human melanoma cells.

Autor: Weiss MB; Department of Cancer Biology and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA., Abel EV, Mayberry MM, Basile KJ, Berger AC, Aplin AE

Publikováno v: Cancer research [Cancer Res] 2012 Dec 15; Vol. 72 (24), pp. 6382-92. Date of Electronic Publication: 2012 Dec 07.

Downregulation of Noxa by RAF/MEK inhibition counteracts cell death response in mutant B-RAF melanoma cells.

Autor: Basile KJ; Department of Cancer Biology and Kimmel Cancer Center, Thomas Jefferson University 233 South 10th Street, Philadelphia, PA 19107, USA., Aplin AE

Publikováno v: American journal of cancer research [Am J Cancer Res] 2012; Vol. 2 (6), pp. 726-35. Date of Electronic Publication: 2012 Nov 20.