Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Basile I M Wicky"'
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e80261 (2013)
Transcription Activator-Like (TAL) effectors are DNA-binding proteins secreted by phytopathogenic bacteria that interfere with native cellular functions by binding to plant DNA promoters. The key element of their architecture is a domain of tandem-re
Externí odkaz:
https://doaj.org/article/13807a07284e4505a67fb14f93ba350d
Autor:
Ryan D. Kibler, Sangmin Lee, Madison A. Kennedy, Basile I. M. Wicky, Stella M. Lai, Marius M. Kostelic, Xinting Li, Cameron M. Chow, Lauren Carter, Vicki H. Wysocki, Barry L. Stoddard, David Baker
Pseudosymmetric hetero-oligomers with three or more unique subunits with overall structural (but not sequence) symmetry play key roles in biology, and systematic approaches for generating such proteinsde novowould provide new routes to controlling ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2628e2e7ede05f8a26f2b79c0c760e93
https://doi.org/10.1101/2023.04.07.535760
https://doi.org/10.1101/2023.04.07.535760
Autor:
Robert Verkuil, Ori Kabeli, Yilun Du, Basile I. M. Wicky, Lukas F. Milles, Justas Dauparas, David Baker, Sergey Ovchinnikov, Tom Sercu, Alexander Rives
Learning the design patterns of proteins from sequences across evolution may have promise toward generative protein design. However it is unknown whether language models, trained on sequences of natural proteins, will be capable of more than memoriza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::966be29e26182e1e9f5967fac865ec09
https://doi.org/10.1101/2022.12.21.521521
https://doi.org/10.1101/2022.12.21.521521
Autor:
Joseph L. Watson, David Juergens, Nathaniel R. Bennett, Brian L. Trippe, Jason Yim, Helen E. Eisenach, Woody Ahern, Andrew J. Borst, Robert J. Ragotte, Lukas F. Milles, Basile I. M. Wicky, Nikita Hanikel, Samuel J. Pellock, Alexis Courbet, William Sheffler, Jue Wang, Preetham Venkatesh, Isaac Sappington, Susana Vázquez Torres, Anna Lauko, Valentin De Bortoli, Emile Mathieu, Regina Barzilay, Tommi S. Jaakkola, Frank DiMaio, Minkyung Baek, David Baker
There has been considerable recent progress in designing new proteins using deep learning methods1–9. Despite this progress, a general deep learning framework for protein design that enables solution of a wide range of design challenges, includingd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33b3dc2111101afaf7ffd55bbbc5fd12
https://doi.org/10.1101/2022.12.09.519842
https://doi.org/10.1101/2022.12.09.519842
Autor:
Linna An, Derrick R Hicks, Dmitri Zorine, Justas Dauparas, Basile I. M. Wicky, Lukas F. Milles, Alexis Courbet, Asim K. Bera, Hannah Nguyen, Alex Kang, Lauren Carter, David Baker
In pseudocyclic proteins such as TIM barrels, β barrels, and some helical transmembrane channels, a single subunit is repeated in a cyclic pattern, giving rise to a central cavity which can serve as a pocket for ligand binding or enzymatic activity.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65fa9895ece579b995a6f26482e5c841
https://doi.org/10.1101/2022.09.01.506251
https://doi.org/10.1101/2022.09.01.506251
Autor:
Jason Z. Zhang, Hsien-Wei Yeh, Alexandra C. Walls, Basile I. M. Wicky, Kaitlin R. Sprouse, Laura A. VanBlargan, Rebecca Treger, Alfredo Quijano-Rubio, Minh N. Pham, John C. Kraft, Ian C. Haydon, Wei Yang, Michelle DeWitt, John E. Bowen, Cameron M. Chow, Lauren Carter, Rashmi Ravichandran, Mark H. Wener, Lance Stewart, David Veesler, Michael S. Diamond, Alexander L. Greninger, David M. Koelle, David Baker
Publikováno v:
Nature biotechnology, vol 40, iss 9
We designed a protein biosensor that uses thermodynamic coupling for sensitive and rapid detection of neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants in serum. The biosensor is a switchable, caged
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::458cd9dfec1e4f5632dd9fdbf5b270ba
https://escholarship.org/uc/item/1b11v74r
https://escholarship.org/uc/item/1b11v74r
Autor:
Basile I. M. Wicky, Philip Rowell, Andrew J. Wilson, Brian R. Jackson, Fatima Nadat, Jane Clarke, Darren C. Tomlinson, Pallavi Ramsahye, Jennifer A. Miles, James E. Taylor, Fruzsina Hobor, Hannah F. Kyle, Thomas A. Edwards, Christian Tiede, Chi H. Trinh
Publikováno v:
Chembiochem
Abstract: The BCL‐2 family is a challenging group of proteins to target selectively due to sequence and structural homologies across the family. Selective ligands for the BCL‐2 family regulators of apoptosis are useful as probes to understand cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99fecebc40604280f0bb35094642d1e8
http://europepmc.org/articles/PMC7821230
http://europepmc.org/articles/PMC7821230
Autor:
Matthew S. Wilken, Florian Busch, Zibo Chen, Ryan Kibler, Galen Dods, Vicki H. Wysocki, Christie Ciarlo, Mengxuan Jia, Hanna Liao, Michael C. Jewett, John A. Stamatoyannopoulos, Jocelynn R. Pearl, Basile I. M. Wicky, Shon Green, David Baker, Zachary L. VanAernum, Hana El-Samad, Scott E. Boyken, Andrew Hunt
Publikováno v:
Science
Designer gates Signaling in cells can occur through protein-protein interactions. Chen et al. describe the design of logic gates that can regulate protein association. The gates were built from small, designed proteins that all have a similar structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de8ef1f35b344f8981120798e53c38a6
https://doi.org/10.1126/science.aay2790
https://doi.org/10.1126/science.aay2790
Autor:
Danny D. Sahtoe, Florian Praetorius, Alexis Courbet, Yang Hsia, Basile I. M. Wicky, Natasha I. Edman, Lauren M. Miller, Bart J. R. Timmermans, Justin Decarreau, Hana M. Morris, Alex Kang, Asim K. Bera, David Baker
Publikováno v:
Science. 375
Asymmetric multiprotein complexes that undergo subunit exchange play central roles in biology but present a challenge for design because the components must not only contain interfaces that enable reversible association but also be stable and well be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7906ff67d195ff1a34a05f7b985ecd2f
https://doi.org/10.1126/science.abj7662
https://doi.org/10.1126/science.abj7662
Autor:
Lauren Miller, David Baker, Natasha I. Edman, Bart J. R. Timmermans, Basile I. M. Wicky, Asim K. Bera, Danny D. Sahtoe, Hana M. Morris, Florian Praetorius, Alexis Courbet, Yang Hsia, Alex Kang
Asymmetric multi-protein complexes that undergo subunit exchange play central roles in biology, but present a challenge for protein design. The individual components must contain interfaces enabling reversible addition to and dissociation from the co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::45fc92d25d4e26880d05c7f103e50a0c
https://doi.org/10.1101/2021.08.15.456388
https://doi.org/10.1101/2021.08.15.456388