Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Basic and Translational Investigation"'
Publikováno v:
Academic Pediatrics
Autor:
Ralf S. Schmid, C. Ryan Miller, Onyi Okolie, Juli R. Bagó, Shawn Hingtgen, Ryan E. Bash, David M. Irvin
Publikováno v:
Neuro-Oncology. 18:1622-1633
Background Surgical resection is a universal component of glioma therapy. Little is known about the postoperative microenvironment due to limited preclinical models. Thus, we sought to develop a glioma resection and recurrence model in syngeneic immu
Autor:
Francesco Olimpico, Silvia Middei, Matteo Caleo, Laura Baroncelli, Gudula Schmidt, Liam A. McDonnell, Martine Ammassari-Teule, Mario Costa, Alessia Fabbri, Carla Fiorentini, Erik L. de Graaf, Eleonora Vannini
Publikováno v:
Journal of neuro-oncology 18 (2016): 1634–1643. doi:10.1093/neuonc/now114
info:cnr-pdr/source/autori:Vannini, E.; Olimpico, F.; Middei, S.; Ammassari-Teule, M.; de Graaf, EL.; McDonnell, L.; Schmidt, G.; Fabbri, A.; Fiorentini, C.; Baroncelli, L.; Costa, M.; Caleo, M./titolo:Electrophysiology of glioma: a Rho GTPase-activating protein reduces tumor growth and spares neuron structure and function/doi:10.1093%2Fneuonc%2Fnow114/rivista:Journal of neuro-oncology/anno:2016/pagina_da:1634/pagina_a:1643/intervallo_pagine:1634–1643/volume:18
Europe PubMed Central
info:cnr-pdr/source/autori:Vannini, E.; Olimpico, F.; Middei, S.; Ammassari-Teule, M.; de Graaf, EL.; McDonnell, L.; Schmidt, G.; Fabbri, A.; Fiorentini, C.; Baroncelli, L.; Costa, M.; Caleo, M./titolo:Electrophysiology of glioma: a Rho GTPase-activating protein reduces tumor growth and spares neuron structure and function/doi:10.1093%2Fneuonc%2Fnow114/rivista:Journal of neuro-oncology/anno:2016/pagina_da:1634/pagina_a:1643/intervallo_pagine:1634–1643/volume:18
Europe PubMed Central
Background Glioblastomas are the most aggressive type of brain tumor. A successful treatment should aim at halting tumor growth and protecting neuronal cells to prevent functional deficits and cognitive deterioration. Here, we exploited a Rho GTPase-
Autor:
Ningyi Tiao, Soon Young Park, Daniel L. Flynn, Bryan D. Smith, Yuji Piao, Verlene Henry, John de Groot
Publikováno v:
Neuro-Oncology. 18:1230-1241
Background Glioblastoma highly expresses the proto-oncogene MET in the setting of resistance to bevacizumab. MET engagement by hepatocyte growth factor (HGF) results in receptor dimerization and autophosphorylation mediating tumor growth, invasion, a
Autor:
Jie Huang, Elena M. Akhmametyeva, Rulong Shen, Beth A. Miles-Markley, Long-Sheng Chang, Li Pan, D. Bradley Welling, Sarah S. Burns, Aaron C. Moberly, Janet L. Oblinger, Yulin Ren, A. Douglas Kinghorn
Publikováno v:
Neuro-Oncology. 18:1265-1277
Background The eukaryotic initiation factor 4F (eIF4F) complex plays a pivotal role in protein translation initiation; however, its importance in malignant and benign Schwann cell tumors has not been explored, and whether blocking eIF4F function is e
Autor:
Emese Szabo, Frank Herting, Elisabeth J. Rushing, Katharina Seystahl, Michael Weller, Hannah Schneider, K. Michael Weidner
Publikováno v:
Neuro-Oncology
BACKGROUND Although the vascular endothelial growth factor (VEGF)/VEGF receptor (VEGFR) system has become a prime target for antiangiogenic treatment, its biological role in glioblastoma beyond angiogenesis has remained controversial. METHODS Using n
Autor:
Jonathan Weller, Annegret Kathagen-Buhmann, Mareike Holz, Rainer Glass, Christel Herold-Mende, Katrin Lamszus, Alexander Schulte
Publikováno v:
Neuro-Oncology. 18:1219-1229
Background. The dichotomy between glioblastoma cell migration and proliferation is regulated by various parameters including oxygen tension. In glioblastoma stem-like cells, hypoxia induces downregulation of pentose phosphate pathway (PPP) enzymes an
Autor:
Claire Sinai, Peter E. Manley, Ryan O’Rourke, Azra H. Ligon, Rebecca D. Folkerth, Mariella G. Filbin, Sanda Alexandrescu, Shakti H. Ramkissoon, Pratiti Bandopadhayay, Rameen Beroukhim, Katherine A. Janeway, Marian H. Harris, Jaeho Hwang, Karen Wright, Ashley S. Plant, Adrian M. Dubuc, Mark W. Kieran, Michael S. Chang, Hart G.W. Lidov, Patricia Ho, Liliana Goumnerova, Matthew D. Ducar, Keith L. Ligon, Sandro Santagata, Susan N. Chi, Lori A. Ramkissoon, Wenya Linda Bi, Charles D. Stiles, Noah F. Greenwald, Edward Yang, Alanna J. Church, Neal I. Lindeman, Ivana Delalle, Laura E. MacConaill, Nathan Pinches, Steven E. Schumacher, Hayley Malkin
Publikováno v:
Neuro-oncology. 19(7)
Background Clinical genomics platforms are needed to identify targetable alterations, but implementation of these technologies and best practices in routine clinical pediatric oncology practice are not yet well established. Methods Profile is an inst
Autor:
Sen Peng, Jeff Kiefer, Nhan L. Tran, Bodour Salhia, Brock Armstrong, Christophe Legendre, Harshil Dhruv, Jill S. Barnholtz-Sloan, Quinn T. Ostrom, Michael E. Berens, Selene Virk, Julianna Parks, Andrew E. Sloan
Publikováno v:
Neuro-oncology. 19(6)
Background To elucidate molecular features associated with disproportionate survival of glioblastoma (GB) patients, we conducted deep genomic comparative analysis of a cohort of patients receiving standard therapy (surgery plus concurrent radiation a
Autor:
Alexander Pomerantz, Timothy A. Chan, Johnathan A. Engh, Gary Kohanbash, Michael T. Lotze, Yongseok Park, Jaehyuk Choi, Nduka Amankulor, Wi Jin Kim, Aparana Rao, Paola Grandi, Hideho Okada, Xiaoran Zhang, Yigang Chang, Paola Sette, Christopher P Deibert
Publikováno v:
Neuro-oncology, vol 18, iss 10
BackgroundDiffuse gliomas are poorly immunogenic, fatal brain tumors. The basis for insufficient antitumor immunity in diffuse gliomas is unknown. Gain-of-function mutations in isocitrate dehydrogenases (IDH1 and IDH2) promote diffuse glioma formatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1af41924be3330d9b5aef05e7b54f5fe
https://escholarship.org/uc/item/4ht070m4
https://escholarship.org/uc/item/4ht070m4