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Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool.

Autor: Sannerud R; VIB Center for the Biology of Disease, KU Leuven, 3000 Leuven, Belgium; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium., Esselens C; VIB Center for the Biology of Disease, KU Leuven, 3000 Leuven, Belgium; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium., Ejsmont P; VIB Center for the Biology of Disease, KU Leuven, 3000 Leuven, Belgium; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium., Mattera R; Cell Biology and Neurobiology Branch, NICHD, NIH, Bethesda, MD 20892, USA., Rochin L; Institut Curie, PSL Research University, CNRS, UMR 144, Paris 75005, France; CNRS, UMR 144, Paris 75005, France., Tharkeshwar AK; VIB Center for the Biology of Disease, KU Leuven, 3000 Leuven, Belgium; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium., De Baets G; VIB Switch Laboratory, KU Leuven, 3000 Leuven, Belgium; Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium., De Wever V; Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium., Habets R; Department of Radiotherapy (MAASTRO)/GROW, Maastricht University, 6211 Maastricht, the Netherlands., Baert V; VIB Center for the Biology of Disease, KU Leuven, 3000 Leuven, Belgium; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium., Vermeire W; VIB Center for the Biology of Disease, KU Leuven, 3000 Leuven, Belgium; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium., Michiels C; VIB Center for the Biology of Disease, KU Leuven, 3000 Leuven, Belgium; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium., Groot AJ; Department of Radiotherapy (MAASTRO)/GROW, Maastricht University, 6211 Maastricht, the Netherlands., Wouters R; VIB Center for the Biology of Disease, KU Leuven, 3000 Leuven, Belgium; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium., Dillen K; VIB Center for the Biology of Disease, KU Leuven, 3000 Leuven, Belgium; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium., Vints K; VIB BioImaging Core, 3000 Leuven, Belgium., Baatsen P; VIB BioImaging Core, 3000 Leuven, Belgium., Munck S; VIB BioImaging Core, 3000 Leuven, Belgium., Derua R; Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium., Waelkens E; Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium., Basi GS; Avalanche Biotechnology, Menlo Park, CA 94025, USA., Mercken M; Janssen Pharmaceutica, 2340 Beerse, Belgium., Vooijs M; Department of Radiotherapy (MAASTRO)/GROW, Maastricht University, 6211 Maastricht, the Netherlands., Bollen M; Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium., Schymkowitz J; VIB Switch Laboratory, KU Leuven, 3000 Leuven, Belgium; Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium., Rousseau F; VIB Switch Laboratory, KU Leuven, 3000 Leuven, Belgium; Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium., Bonifacino JS; Cell Biology and Neurobiology Branch, NICHD, NIH, Bethesda, MD 20892, USA., Van Niel G; Institut Curie, PSL Research University, CNRS, UMR 144, Paris 75005, France; CNRS, UMR 144, Paris 75005, France., De Strooper B; VIB Center for the Biology of Disease, KU Leuven, 3000 Leuven, Belgium; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium; Department of Molecular Neuroscience, UCL Institute of Neurology, London WC1E 6BT, UK., Annaert W; VIB Center for the Biology of Disease, KU Leuven, 3000 Leuven, Belgium; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium. Electronic address: wim.annaert@cme.vib-kuleuven.be.

Publikováno v: Cell [Cell] 2016 Jun 30; Vol. 166 (1), pp. 193-208. Date of Electronic Publication: 2016 Jun 09.