Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Basel M. Al-Barghouthi"'
Autor:
Basel M. Al-Barghouthi, Larry D. Mesner, Gina M. Calabrese, Daniel Brooks, Steven M. Tommasini, Mary L. Bouxsein, Mark C. Horowitz, Clifford J. Rosen, Kevin Nguyen, Samuel Haddox, Emily A. Farber, Suna Onengut-Gumuscu, Daniel Pomp, Charles R. Farber
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Osteoporosis GWAS faces two challenges, causal gene discovery and a lack of phenotypic diversity. Here, the authors use the Diversity Outbred mouse population to inform human GWAS using networks and map genetic loci for 55 bone traits, identifying ne
Externí odkaz:
https://doaj.org/article/4e2ac2ef78f74d52bdfce93123908f3a
Autor:
Luke J Dillard, Will T Rosenow, Gina M Calabrese, Larry D Mesner, Basel M Al-Barghouthi, Abdullah Abood, Emily A Farber, Suna Onengut-Gumuscu, Steven M Tommasini, Mark A Horowitz, Clifford J Rosen, Lutian Yao, Ling Qin, Charles R Farber
Genome-wide association studies (GWASs) have revolutionized our understanding of the genetics of complex diseases, such as osteoporosis; however, the challenge has been converting associations to causal genes. Studies have demonstrated the utility of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1cd743a09b7043b2445d1f5ef66219c2
https://doi.org/10.1101/2022.12.13.520148
https://doi.org/10.1101/2022.12.13.520148
Autor:
Abdullah Abood, Larry Mesner, Will Rosenow, Basel M. Al‐Barghouthi, Nina Horowitz, Elise F. Morgan, Louis C. Gerstenfeld, Charles R. Farber
Publikováno v:
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 37(8)
Osteoporosis, characterized by low bone mineral density (BMD), is the most common complex disease affecting bone and constitutes a major societal health problem. Genome-wide association studies (GWASs) have identified over 1100 associations influenci
Autor:
null Abdullah Abood, null Larry Mesner, null Will Rosenow, null Basel M. Al‐Barghouthi, null Nina Horwitz, null Elise F. Morgan, null Louis C. Gerstenfeld, null Charles R. Farber
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99d0d84161192d2aefc6ba47024be66c
https://doi.org/10.1002/jbmr.4622/v2/response1
https://doi.org/10.1002/jbmr.4622/v2/response1
Autor:
Meghan M. Moran, Frank C. Ko, Larry D. Mesner, Gina M. Calabrese, Basel M. Al-Barghouthi, Charles R. Farber, D. Rick Sumner
Publikováno v:
Bone
There are over one million cases of failed bone repair in the U.S. annually, resulting in substantial patient morbidity and societal costs. Multiple candidate genes affecting bone traits such as bone mineral density have been identified in human subj
Autor:
Louis C. Gerstenfeld, Nina Horwitz, Will T. Rosenow, Basel M. Al-Barghouthi, Larry D. Mesner, Charles R. Farber, Abdullah Abood, Elise F. Morgan
Osteoporosis, characterized by low bone mineral density (BMD), is the most common complex disease affecting bone and constitutes a major societal health problem. Genome-wide association studies (GWASs) have identified over 1100 associations influenci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44ca9ef35610a9b64880baeed3f085a3
https://doi.org/10.1101/2021.11.04.467171
https://doi.org/10.1101/2021.11.04.467171
Autor:
Jinho Heo, Will T. Rosenow, Virginia L. Ferguson, Kang-Ping Du, David L. Brautigan, Robert D. Maynard, Louis C. Gerstenfeld, Larry D. Mesner, Elise F. Morgan, Bhavya Senwar, Gina M. Calabrese, Charles R. Farber, Aaron Nakasone, Cheryl L. Ackert-Bicknell, Basel M. Al-Barghouthi
Genome-wide association studies (GWASs) for bone mineral density (BMD) have identified over 1,100 associations to date. However, identifying causal genes implicated by such studies has been challenging. Recent advances in the development of transcrip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8e7a18f51c003bcd5283211eb1fb6404
https://doi.org/10.1101/2021.10.12.464046
https://doi.org/10.1101/2021.10.12.464046
Autor:
Charles R. Farber, Clifford J. Rosen, Larry D. Mesner, Daniel J. Brooks, Steven M. Tommasini, Emily Farber, Kevin Nguyen, Samuel Haddox, Basel M. Al-Barghouthi, Suna Onengut-Gumuscu, Daniel Pomp, Mark C. Horowitz, Gina M. Calabrese, Mary L. Bouxsein
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Genome-wide association studies (GWASs) for osteoporotic traits have identified over 1000 associations; however, their impact has been limited by the difficulties of causal gene identification and a strict focus on bone mineral density (BMD). Here, w
Publikováno v:
Trends in Genetics. 35:55-67
Osteoporosis is a condition characterized by low bone mineral density (BMD) and an increased risk of fracture. Traits contributing to osteoporotic fracture are highly heritable, indicating that a comprehensive understanding of bone requires a thoroug
Autor:
Karol Szlachta, Maureen A. Carey, Jennifer L. Guler, Adam C Huckaby, Yuh-Hwa Wang, Claire S Granum, Basel M. Al-Barghouthi
Publikováno v:
Nucleic Acids Research
Antimalarial resistance is a major obstacle in the eradication of the human malaria parasite, Plasmodium falciparum. Genome amplifications, a type of DNA copy number variation (CNV), facilitate overexpression of drug targets and contribute to parasit