Zobrazeno 1 - 10
of 532
pro vyhledávání: '"Base exchange"'
Publikováno v:
Molecules, Vol 29, Iss 4, p 847 (2024)
Here, we report an adapted protocol using the Promega NAD/NADH-Glo™ Assay kit. The assay normally allows quantification of trace amounts of both oxidized and reduced forms of nicotinamide adenine dinucleotide (NAD) by enzymatic cycling, but we now
Externí odkaz:
https://doaj.org/article/15de90121f724784acf0e38f8755f98a
Autor:
Tong Wu, Jian Zhu, Amy Strickland, Kwang Woo Ko, Yo Sasaki, Caitlin B. Dingwall, Yurie Yamada, Matthew D. Figley, Xianrong Mao, Alicia Neiner, A. Joseph Bloom, Aaron DiAntonio, Jeffrey Milbrandt
Publikováno v:
Cell Reports, Vol 37, Iss 3, Pp 109872- (2021)
Summary: SARM1 is an inducible TIR-domain NAD+ hydrolase that mediates pathological axon degeneration. SARM1 is activated by an increased ratio of NMN to NAD+, which competes for binding to an allosteric activating site. When NMN binds, the TIR domai
Externí odkaz:
https://doaj.org/article/de9f3f8581274b08b0ab0cc8ca1a999f
Autor:
Wan Hua Li, Ke Huang, Yang Cai, Qian Wen Wang, Wen Jie Zhu, Yun Nan Hou, Sujing Wang, Sheng Cao, Zhi Ying Zhao, Xu Jie Xie, Yang Du, Chi-Sing Lee, Hon Cheung Lee, Hongmin Zhang, Yong Juan Zhao
Publikováno v:
eLife, Vol 10 (2021)
SARM1 regulates axonal degeneration through its NAD-metabolizing activity and is a drug target for neurodegenerative disorders. We designed and synthesized fluorescent conjugates of styryl derivative with pyridine to serve as substrates of SARM1, whi
Externí odkaz:
https://doaj.org/article/ad4f471898f24bb6b9401388eb12196c
Akademický článek
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Publikováno v:
Biomolecules, Vol 11, Iss 7, p 1044 (2021)
It has recently been demonstrated that the rat poison vacor interferes with mammalian NAD metabolism, because it acts as a nicotinamide analog and is converted by enzymes of the NAD salvage pathway. Thereby, vacor is transformed into the NAD analog v
Externí odkaz:
https://doaj.org/article/3b55d39c09a84595a8069cf8841a750d
Publikováno v:
Biomolecules, Vol 11, Iss 2, p 312 (2021)
SIRT1 is the most extensively studied human sirtuin with a broad spectrum of endogenous targets. It has been implicated in the regulation of a myriad of cellular events, such as gene transcription, mitochondria biogenesis, insulin secretion as well a
Externí odkaz:
https://doaj.org/article/875d86bcdba14889977d94104c267269
Autor:
Ozioma Udochukwu Akakuru, H. O. Nwankwoala, Bernard E. Akudinobi, S. O. Onyekuru, Obinna Chigoziem Akakuru
Publikováno v:
Geosciences Journal. 25:915-927
The hydrogeochemical evolution and irrigation suitability assessment of groundwater in selected parts of Asaba, Nigeria, has been conducted. The purpose of this study was to ascertain the hydrogeochemical relations and interactions of groundwater wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a0862be41b5186f7ea3fa3533cc8999
https://doi.org/10.1007/s12303-021-0010-x
https://doi.org/10.1007/s12303-021-0010-x
Akademický článek
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Akademický článek
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You provide us with a matroid and an initial base. We say that a subset of the bases "belongs to us" if we can visit each one via a sequence of base exchanges starting from the initial base. It is well-known that "All your base are belong to us". We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9257f638ad60a26f30068f23d7ee6b00
