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GABA(A) Receptor Activation Drives GABARAP-Nix Mediated Autophagy to Radiation-Sensitize Primary and Brain-Metastatic Lung Adenocarcinoma Tumors.

Autor: Bhattacharya D; Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA., Barrile R; Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH 45221, USA., Toukam DK; Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA., Gawali VS; Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA., Kallay L; Department of Neurology and Rehabilitation Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA., Ahmed T; Department of Chemistry and Biochemistry, Milwaukee Institute of Drug Discovery, University of Wisconsin, Milwaukee, WI 53211, USA., Brown H; Department of Chemistry, Tufts University, Medford, MA 02144, USA., Rezvanian S; Department of Chemistry and Biochemistry, Milwaukee Institute of Drug Discovery, University of Wisconsin, Milwaukee, WI 53211, USA., Karve A; Division of Pharmaceutical Sciences, University of Cincinnati College of Pharmacy, Cincinnati, OH 45229, USA., Desai PB; Division of Pharmaceutical Sciences, University of Cincinnati College of Pharmacy, Cincinnati, OH 45229, USA., Medvedovic M; Department of Environmental & Public Health Sciences, University of Cincinnati, Cincinnati, OH 45267, USA., Wang K; Department of Radiation Oncology, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA., Ionascu D; Department of Radiation Oncology, University of Cincinnati College of Medicine, Cincinnati, OH 45219, USA., Harun N; Division of Biostatistics & Epidemiology, Cincinnati Children's Hospital, Cincinnati, OH 45229, USA., Vallabhapurapu S; Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA., Wang C; Department of Cancer Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA., Qi X; Division of Hematology and Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA., Baschnagel AM; Department of Human Oncology, University of Wisconsin, Madison, WI 53792, USA., Kritzer JA; Department of Chemistry, Tufts University, Medford, MA 02144, USA., Cook JM; Department of Chemistry and Biochemistry, Milwaukee Institute of Drug Discovery, University of Wisconsin, Milwaukee, WI 53211, USA., Pomeranz Krummel DA; Department of Neurosurgery, University of North Carolina, Chapel Hill, NC 27599, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA., Sengupta S; Department of Neurosurgery, University of North Carolina, Chapel Hill, NC 27599, USA.; Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.; Department of Neurology, University of North Carolina, Chapel Hill, NC 27517, USA.

Publikováno v: Cancers [Cancers (Basel)] 2024 Sep 15; Vol. 16 (18). Date of Electronic Publication: 2024 Sep 15.

DARES: A Phase II Trial of Durvalumab and Ablative Radiation in Extensive-Stage Small Cell Lung Cancer.

Autor: Bestvina CM; Department of Medicine, Section of Hematology and Oncology, The University of Chicago Medicine, Chicago, IL., Hara JHL; Department of Radiation Oncology, The Queen's Medical Center, Honolulu, HI., Karrison T; Department of Public Health Sciences, The University of Chicago, Chicago, IL., Bowar B; Department of Pharmacy, University of Chicago Medical Center, Chicago, IL., Chin J; Department of Medicine, Section of Hematology and Oncology, The University of Chicago Medicine, Chicago, IL., Garassino MC; Department of Medicine, Section of Hematology and Oncology, The University of Chicago Medicine, Chicago, IL., Pitroda SP; Department of Radiation and Cellular Oncology, The University of Chicago Medicine, Chicago, IL., Thawani R; Department of Medicine, Section of Hematology and Oncology, The University of Chicago Medicine, Chicago, IL., Vokes EE; Department of Medicine, Section of Hematology and Oncology, The University of Chicago Medicine, Chicago, IL., Gan G; Department of Radiation Oncology, Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS., Zhang J; Department of Internal Medicine, Division of Medical Oncology; Department of Cancer Biology, University of Kansas Medical Center, Kansas City, KS., Baschnagel AM; Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI., Campbell TC; Department of Medicine, University of Wisconsin-Madison, Madison, WI., Chmura S; Department of Radiation and Cellular Oncology, The University of Chicago Medicine, Chicago, IL., Juloori A; Department of Radiation and Cellular Oncology, The University of Chicago Medicine, Chicago, IL. Electronic address: ajuloori@radonc.uchicago.edu.

Publikováno v: Clinical lung cancer [Clin Lung Cancer] 2024 Dec; Vol. 25 (8), pp. e448-e452. Date of Electronic Publication: 2024 Aug 13.

Leveraging radiomics and machine learning to differentiate radiation necrosis from recurrence in patients with brain metastases.

Autor: Basree MM; Deparment of Human Oncology, University of Wisconsin, Madison, WI, USA., Li C; Department of Computer Science, University of Wisconsin, Madison, WI, USA., Um H; Department of Radiology, University of Wisconsin, Madison, WI, USA., Bui AH; School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA., Liu M; School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA., Ahmed A; Department of Neurological Surgery, University of Wisconsin, Madison, WI, USA., Tiwari P; Department of Radiology, University of Wisconsin, Madison, WI, USA., McMillan AB; Department of Radiology, University of Wisconsin, Madison, WI, USA. amcmillan@uwhealth.org.; Department of Biomedical Engineering, College of Engineering, University of Wisconsin, Madison, WI, USA. amcmillan@uwhealth.org.; Department of Medical Physics, University of Wisconsin, Madison, WI, USA. amcmillan@uwhealth.org., Baschnagel AM; School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA. baschnagel@humonc.wisc.edu.; University of Wisconsin Carbone Cancer Center, University of Wisconsin, Madison, WI, USA. baschnagel@humonc.wisc.edu.

Publikováno v: Journal of neuro-oncology [J Neurooncol] 2024 Jun; Vol. 168 (2), pp. 307-316. Date of Electronic Publication: 2024 Apr 30.

MET Inhibitor Capmatinib Radiosensitizes MET Exon 14-Mutated and MET-Amplified Non-Small Cell Lung Cancer.

Autor: Ramesh S; Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin., Cifci A; Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin., Javeri S; Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin., Minne RL; Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin., Longhurst CA; Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin., Nickel KP; Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin., Kimple RJ; Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin; University of Wisconsin Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin. Electronic address: rkimple@humonc.wisc.edu., Baschnagel AM; Department of Human Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin; University of Wisconsin Carbone Cancer Center, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin. Electronic address: baschnagel@humonc.wisc.edu.

Publikováno v: International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2024 Apr 01; Vol. 118 (5), pp. 1379-1390. Date of Electronic Publication: 2023 Nov 16.