Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Basavraj, Khanppnavar"'
Autor:
Xinyue Ding, Simone Aureli, Anand Vaithia, Pia Lavriha, Dina Schuster, Basavraj Khanppnavar, Xiaodan Li, Thorsten B. Blum, Paola Picotti, Francesco L. Gervasio, Volodymyr M. Korkhov
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-4 (2024)
Externí odkaz:
https://doaj.org/article/6d8c7a3f62634a05b3d02d16dab59e5a
Autor:
Aleš Holfeld, Dina Schuster, Fabian Sesterhenn, Alison K Gillingham, Patrick Stalder, Walther Haenseler, Inigo Barrio-Hernandez, Dhiman Ghosh, Jane Vowles, Sally A Cowley, Luise Nagel, Basavraj Khanppnavar, Tetiana Serdiuk, Pedro Beltrao, Volodymyr M Korkhov, Sean Munro, Roland Riek, Natalie de Souza, Paola Picotti
Publikováno v:
Molecular Systems Biology, Vol 20, Iss 6, Pp 651-675 (2024)
Abstract The physical interactome of a protein can be altered upon perturbation, modulating cell physiology and contributing to disease. Identifying interactome differences of normal and disease states of proteins could help understand disease mechan
Externí odkaz:
https://doaj.org/article/111e459619b140979ac5a006ab8a5025
Autor:
Basavraj Khanppnavar, Julian Maier, Freja Herborg, Ralph Gradisch, Erika Lazzarin, Dino Luethi, Jae-Won Yang, Chao Qi, Marion Holy, Kathrin Jäntsch, Oliver Kudlacek, Klaus Schicker, Thomas Werge, Ulrik Gether, Thomas Stockner, Volodymyr M. Korkhov, Harald H. Sitte
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
The current work reports the structure of the human organic cation transporter 3 (OCT3 / SLC22A3) and provides the structural basis of its inhibition by two specific inhibitors, decynium-22 and corticosterone.
Externí odkaz:
https://doaj.org/article/c390514bb74345508edbb1e105eb04af
Autor:
Chao Qi, Pia Lavriha, Ved Mehta, Basavraj Khanppnavar, Inayathulla Mohammed, Yong Li, Michalis Lazaratos, Jonas V. Schaefer, Birgit Dreier, Andreas Plückthun, Ana-Nicoleta Bondar, Carmen W. Dessauer, Volodymyr M. Korkhov
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Adenylyl cyclases (ACs) generate the second messenger cAMP and play an important role in cellular signaling. Here, the authors use cryo-EM to trace the conformational changes resulting from binding to partial and full activators to one of these enzym
Externí odkaz:
https://doaj.org/article/8cc716af995d44c680e7cd3d009fb03e
Autor:
Ved Mehta, Basavraj Khanppnavar, Dina Schuster, Ilayda Kantarci, Irene Vercellino, Angela Kosturanova, Tarun Iype, Sasa Stefanic, Paola Picotti, Volodymyr M Korkhov
Publikováno v:
eLife, Vol 11 (2022)
Mycobacterium tuberculosis adenylyl cyclase (AC) Rv1625c/Cya is an evolutionary ancestor of the mammalian membrane ACs and a model system for studies of their structure and function. Although the vital role of ACs in cellular signalling is well estab
Externí odkaz:
https://doaj.org/article/6a21e41f8fdc4cd79054b568a5329337
Publikováno v:
Biochimie. 193:103-114
Ketopantoate reductases (KPRs) catalyse NADPH-dependent reduction of ketopantoate to pantoate, the rate-limiting step of pantothenate biosynthetic pathway. In our recent study, we showed KPRs are under dynamic evolutionary selection and highlighted t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5e4e134bee23499df086a2a2f61e39f
https://doi.org/10.1016/j.biochi.2021.10.015
https://doi.org/10.1016/j.biochi.2021.10.015
Autor:
Basavraj Khanppnavar, Dina Schuster, Merve Özel, Ved Mehta, Alexander Leitner, Paola Picotti, Volodymyr M. Korkhov
Membrane adenylyl cyclase AC8 is regulated by G proteins and calmodulin (CaM), mediating the crosstalk between cAMP pathway and Ca2+signalling. Despite the importance of AC8 in physiology, including cognitive functions and memory, the structural basi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::792745eaa65e3b1b646c075e4039347c
https://doi.org/10.1101/2023.03.03.531047
https://doi.org/10.1101/2023.03.03.531047
Autor:
Aleš Holfeld, Dina Schuster, Fabian Sesterhenn, Patrick Stalder, Walther Haenseler, Inigo Barrio-Hernandez, Dhiman Ghosh, Jane Vowles, Sally A. Cowley, Luise Nagel, Basavraj Khanppnavar, Pedro Beltrao, Volodymyr M. Korkhov, Roland Riek, Natalie de Souza, Paola Picotti
Protein–protein interactions (PPIs) mediate numerous essential functions and regulatory events in living organisms. The physical interactome of a protein can be abnormally altered in response to external and internal cues, thus modulating cell phys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa1cb0d23dc8c001a43c8d7aa361637
Autor:
Basavraj Khanppnavar, Ved Mehta, Dina Schuster, Ilayda Kantarci, Irene Vercellino, Angela Kosturanova, Tarun Iype, Sasa Stefanic, Paola Picotti, Volodymyr M Korkhov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e08ddf41d7a83a595369ebbaab7bf5c5
https://doi.org/10.7554/elife.77032.sa2
https://doi.org/10.7554/elife.77032.sa2
Autor:
Kousik Chandra, Basavraj Khanppnavar, Vladimir N. Uversky, Nakul C. Maiti, Anupam Singha Roy, Saumen Datta
Publikováno v:
International Journal of Biological Macromolecules. 159:18-33
Given that the protein unfolding requisite for type-III secretion system (T3SS)-mediated secretion is an energetically unfavorable process, the question of how do pathogenic bacteria unfold and secrete hundreds of toxic proteins in seconds remain lar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c655dc40c68ae506355d2ade86da8a2a
https://doi.org/10.1016/j.ijbiomac.2020.04.266
https://doi.org/10.1016/j.ijbiomac.2020.04.266