Zobrazeno 1 - 10
of 3 935
pro vyhledávání: '"Basappa"'
Autor:
Sajeela Arif, Shoaib Khan, Tayyiaba Iqbal, Basappa C. Yallur, Fazal Rahim, Rafaqat Hussain, Yousaf Khan, Hayat Ullah
Publikováno v:
Results in Chemistry, Vol 10, Iss , Pp 101706- (2024)
One of the major neurodegenerative disorders, Alzheimer’s disease (AD) was targeted in the current study synthesizing bis-Schiff bases derivatives. All the synthesized scaffolds were found to have a range of IC50 values (2.50 ± 0.10 µM to 19.20
Externí odkaz:
https://doaj.org/article/fd99e3ef69f344b5956b680b34329483
Autor:
Yan Qin Tan, Bowen Sun, Xi Zhang, Shuwei Zhang, Hui Guo, Basappa Basappa, Tao Zhu, Gautam Sethi, Peter E. Lobie, Vijay Pandey
Publikováno v:
Cell Death and Disease, Vol 15, Iss 2, Pp 1-15 (2024)
Abstract Therapeutic targeting of KRAS-mutant pancreatic ductal adenocarcinoma (PDAC) has remained a significant challenge in clinical oncology. Direct targeting of KRAS has proven difficult, and inhibition of the KRAS effectors have shown limited su
Externí odkaz:
https://doaj.org/article/6c51f34c4c554e30809c9c5a3ff25555
Autor:
Liqiong Wang, Xi Zhang, Shu Chen, Qiuhua Ye, Basappa Basappa, Tao Zhu, Peter E. Lobie, Vijay Pandey
Publikováno v:
Translational Oncology, Vol 49, Iss , Pp 102103- (2024)
Objective: Mitomycin C (MMC), a DNA-damaging chemotherapeutic, is commonly used clinically for recurrent cervical carcinoma (CC), either alone or in combination. MMC generates DNA damage resulting in CC cell death yet also induces increased AKT-BAD p
Externí odkaz:
https://doaj.org/article/b248bb94535646d2bef4b5efc0bed8d8
Autor:
Na Young Kim, Dukanya Dukanya, Gautam Sethi, Swamy S Girimanchanaika, Jirui Yang, Omantheswara Nagaraja, Ananda Swamynayaka, Divakar Vishwanath, Keerthikumara Venkantesha, Shreeja Basappa, Arunachalam Chinnathambi, Sulaiman Ali Alharbi, Mahendra Madegowda, Alexey Sukhorukov, Vijay Pandey, Peter E. Lobie, Basappa Basappa, Kwang Seok Ahn
Publikováno v:
Translational Oncology, Vol 49, Iss , Pp 102101- (2024)
Small molecule-driven JNK activation has been found to induce apoptosis and paraptosis in cancer cells. Herein pharmacological effects of synthetic oxazine (4aS, 7aS)-3-((4-(4‑chloro-2-fluorophenyl)piperazin-1-yl)methyl)-4-phenyl-4, 4a, 5, 6, 7, 7a
Externí odkaz:
https://doaj.org/article/6719bc3a38394d8688d5d7884b2aea4a
Autor:
Jie Yuan, Bhanuprakash C. Narasimhachar, Akshay Ravish, Li Yang, Hua Zhang, Qun Wang, Zhi Li, Jun Huang, Bei Wang, Geng Wang, Keshav Kumar Harish, Arunachalam Chinnathambi, Chandramohan Govindasamy, Mahendra Madegowda, Basappa Basappa
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
IntroductionNuclear factor kappa (NF-κB) plays a key role in cancer cell proliferation; thus, small molecule inhibitors of NF-κB activity can effectively inhibit breast cancer (BC) progression. We have previously reported oxazine and piperazine-lin
Externí odkaz:
https://doaj.org/article/66c2cc0a7bac4368a394f36398fd78cd
Autor:
Yu Cao, Chang Lu, Narasimha M. Beeraka, Sergey Efetov, Mikhail Enikeev, Yu Fu, Xinyi Yang, Basappa Basappa, Mingze He, Zhi Li
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Ferroptosis induces significant changes in mitochondrial morphology, including membrane condensation, volume reduction, cristae alteration, and outer membrane rupture, affecting mitochondrial function and cellular fate. Recent reports have described
Externí odkaz:
https://doaj.org/article/c6b539aaf93846d4beca00da47e527f2
Autor:
Yan Qin Tan, Yi-Shiou Chiou, Hui Guo, Shuwei Zhang, Xiaoming Huang, Dukanya Dukanya, Arun M. Kumar, Shreeja Basappa, Suling Liu, Tao Zhu, Basappa Basappa, Vijay Pandey, Peter E. Lobie
Publikováno v:
npj Precision Oncology, Vol 8, Iss 1, Pp 1-19 (2024)
Abstract Aberrant activation of the PI3K/AKT signaling axis along with the sustained phosphorylation of downstream BAD is associated with a poor outcome of TNBC. Herein, the phosphorylated to non-phosphorylated ratio of BAD, an effector of PI3K/AKT p
Externí odkaz:
https://doaj.org/article/66e441eb7b2d4580828abd005654979b
Publikováno v:
Судебная Медицина, Vol 9, Iss 4, Pp 373-381 (2023)
BACKGROUND: Near-hanging refers to individuals who survive a hanging injury for various durations. However, hospitalized patients succumb to complications resulting in delayed deaths. AIM: to evaluate various factors associated with causes of dela
Externí odkaz:
https://doaj.org/article/f56ae96aab274fd3bd06e22762bd0e8b
Autor:
Lisha K. Poonacha, Rashmi Ramesh, Akshay Ravish, Arunkumar Mohan, Pradeep M. Uppar, Prashant K. Metri, Nanjunda Swamy Shivananju, Santosh L. Gaonkar, Shubha Gopal, Alexey Yu Sukhorukov, Vijay Pandey, Priya Babu Shubha, Basappa Basappa
Publikováno v:
Applied Microbiology, Vol 3, Iss 4, Pp 1214-1228 (2023)
Heterocyclic compounds can specifically regulate bacterial development by targeting specific bacterial enzymes and metabolic pathways. The ESKAPE pathogens are multidrug-resistant and cause nosocomial infections, which is one of the greatest challeng
Externí odkaz:
https://doaj.org/article/9b33de861b99471ab32c0f9333821a16
Publikováno v:
Saudi Dental Journal, Vol 35, Iss 6, Pp 753-759 (2023)
Objectives: To evaluate the clinical and radiographic success rate of blood clot and platelet rich fibrin (PRF) as a scaffold system in regenerative endodontic procedure in immature traumatized necrotic teeth.. Materials and methods: This retrospecti
Externí odkaz:
https://doaj.org/article/ba958aca4caa4945ad21749cce2f6768