Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Bas-jan Van Der Leede"'
Autor:
Sophie Lachau-Durand, Lieve Lammens, Bas-Jan van der Leede, Jacky Van Gompel, Graham Bailey, Marc Engelen, Ann Lampo
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 13, Iss 1, p e0007026 (2019)
BackgroundFlubendazole, originally developed to treat infections with intestinal nematodes, has been shown to be efficacious in animal models of filarial infections. For treatment of filarial nematodes, systemic exposure is needed. For this purpose,
Externí odkaz:
https://doaj.org/article/50a67aea468e47ba8b225ebbe85bb6bd
Autor:
Bas-jan Van Der Leede
Publikováno v:
Frontiers in Genetics, Vol 6 (2015)
In genotoxicity testing of pharmaceuticals the rodent alkaline comet assay is being increasingly used as a second in vivo assay in addition to the in vivo micronucleus assay to mitigate in vitro positive results as recommended by regulatory guidance.
Externí odkaz:
https://doaj.org/article/209c8a90475b444db643c6579630ce62
Autor:
David, Kirkland, James, Whitwell, Robert, Smith, Kiyohiro, Hashimoto, Zhiying, Ji, Julia, Kenny, Naoki, Koyama, David P, Lovell, Hans-Jörg, Martus, Krista, Meurer, Daniel, Roberts, Akira, Takeiri, Yoshifumi, Uno, Bas-Jan, van der Leede, Paul, White, Andreas, Zeller
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. :503503
It is often assumed that genotoxic substances will be detected more easily by using in vitro rather than in vivo genotoxicity tests since higher concentrations, more cytotoxicity and static exposures can be achieved. However, there is a paucity of da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5166c37cab3a21e0dacb0110d01c9e6
https://doi.org/10.1016/j.mrgentox.2022.503503
https://doi.org/10.1016/j.mrgentox.2022.503503
Autor:
David M. DeMarini, Leon F. Stankowski, Rosalie K. Elespuru, Dan D. Levy, Stephanie Simon, Atsushi Hakura, Jonathan Howe, Richard V. Williams, Masayuki Kato, Errol Zeiger, Jasmin Lott, Martha M. Moore, Patricia A. Escobar, Kevin P. Cross, Rita Schoeny, Kei-ichi Sugiyama, Bas-jan van der Leede
Publikováno v:
Mutation research. Genetic toxicology and environmental mutagenesis. 849
The International Workshop on Genotoxicity Testing (IWGT) meets every four years to obtain consensus on unresolved issues associated with genotoxicity testing. At the 2017 IWGT meeting in Tokyo, four sub-groups addressed issues associated with the Or
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a68445e81944516e60ca416255517013
https://pubmed.ncbi.nlm.nih.gov/32087853
https://pubmed.ncbi.nlm.nih.gov/32087853
Autor:
Kathleen De Vlieger, Ann Schuermans, Bas-jan van der Leede, Helena Geys, Marjolein van Heerden, Sandra De Jonghe, Terry Van Doninck, Fetene Tekle, Jacky Van Gompel, Sandy Weiner
Publikováno v:
Environmental and Molecular Mutagenesis
Acetaminophen, a nonmutagenic compound as previously concluded from bacteria, in vitro mammalian cell, and in vivo transgenic rat assays, presented a good profile as a nonmutagenic reference compound for use in the international multilaboratory Pig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3b1bc3f3b77f93d67798463dd79a510
https://pubmed.ncbi.nlm.nih.gov/32187737
https://pubmed.ncbi.nlm.nih.gov/32187737
Autor:
Yann Abraham, Bart Petrus Anna Maria Jozef Medaer, Weimei Sun, Greet Vanhoof, Haopeng Rui, Yusri Elsayed, Sriram Balasubramanian, Ulrike Philippar, Marcello Gaudiano, Jan Willem Thuring, Jenna D. Goldberg, Tianbao Lu, Jennifer Smit, Peter J. Connolly, James P. Edwards, Max Cummings, Emanuele Trella, John Gerecitano, Nele Vloemans, Ricardo Attar, Tony Greway, Katarzyna Wnuk-Lipinska, Jan Linders, Kristof Kimpe, Amy J. Johnson, Jaqueline Bussolari, Bas-jan van der Leede, Luc Van Nuffel, Mariette Bekkers, Katie Amssoms
Publikováno v:
Blood Cancer Discovery. 1:PO-49
Introduction: Constitutive activation of the classical nuclear factor kappa-light-chain-enhancer of activated B cells (NF κB) pathway is a clear driver of B-cell lymphomas, especially the aggressive activated B-cell (ABC) subtype of diffuse large B-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e8109699ae1dad100496dfd36f4ec75
https://doi.org/10.1158/2643-3249.lymphoma20-po-49
https://doi.org/10.1158/2643-3249.lymphoma20-po-49
Autor:
Ulrike Philippar, Tianbao Lu, Nele Vloemans, Mariette Bekkers, Luc Van Nuffel, Marcello Gaudiano, Katarzyna Wnuk-Lipinska, Bas-jan Van Der Leede, Katie Amssoms, Kristof Kimpe, Bart Medaer, Tony Greway, Yann Abraham, Max Cummings, Emanuele Trella, Greet Vanhoof, Weimei Sun, Jan Willem Thuring, Peter Connolly, Jan Linders, Haopeng Rui, Sriram Balasubramanian, Amy Johnson, John Gerecitano, Jenna Goldberg, James P. Edwards, Yusri Elsayed, Jennifer Smit, Jaqueline Bussolari, Ricardo Attar
Publikováno v:
Cancer Research. 80:5690-5690
Introduction: Constitutive activation of the classical nuclear factor kappa-light-chain-enhancer of activated B-cells (NF-κB) pathway is a clear driver of B-cell lymphomas, especially the aggressive activated B-cell (ABC) subtype of diffuse large B-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::504dd7a5e5c4ecf52e6e466854e7daea
https://doi.org/10.1158/1538-7445.am2020-5690
https://doi.org/10.1158/1538-7445.am2020-5690
Autor:
Dan D. Levy, Martha M. Moore, Bas-jan van der Leede, Atsushi Hakura, Kei-ichi Sugiyama, Masayuki Kato, Patricia A. Escobar, Errol Zeiger
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 848:403074
A committee was constituted within the International Workshop on Genetic Toxicology Testing (IWGT) to evaluate the current criteria for a valid Ames test and to provide recommendations for interpretation of test results. Currently, determination of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b83aaeb28d42a3e3206fd720e6809cbb
https://doi.org/10.1016/j.mrgentox.2019.07.004
https://doi.org/10.1016/j.mrgentox.2019.07.004
Autor:
Ulla Plappert-Helbig, M.R. O'Donovan, Bas-jan van der Leede, Jonathan Howe, Ann T. Doherty, Véronique Thybaud, Melanie Guérard
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. :81-88
In genotoxicity testing of pharmaceuticals the rodent alkaline comet assay is being increasingly used as a second in vivo assay in addition to the in vivo micronucleus assay to mitigate in vitro positive results as recommended by the ICH S2(R1) guide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0112deaefb71a1dc796660e5aeda3c98
Autor:
Richard D. Storer, Andreas Rothfuss, Satin Sawant, Ulla Plappert-Helbig, Sheila M. Galloway, Shuichi Hamada, Jonathan Howe, Kazuhiko Saigo, Andreas Czich, Dominique Brault, Andrew R. Kraynak, Michael R. O’Donovan, Bas-jan van der Leede, Melanie Struwe, Makoto Hayashi, Véronique Thybaud, Madoka Nakajima, Marlies De Boeck, Esther Vock, Laura Custer, Catherine C. Priestley, Jing Shi
Publikováno v:
Mutation Research/Genetic Toxicology and Environmental Mutagenesis. 702:40-69
A collaborative trial was conducted to evaluate the possibility of integrating the rat-liver Comet assay into repeat-dose toxicity studies. Fourteen laboratories from Europe, Japan and the USA tested fifteen chemicals. Two chemicals had been previous
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082e1a5863fbd061dff572fe450b2cad
https://doi.org/10.1016/j.mrgentox.2010.07.006
https://doi.org/10.1016/j.mrgentox.2010.07.006