Zobrazeno 1 - 10
of 141
pro vyhledávání: '"Bas van Steensel"'
Autor:
Xabier Vergara, Anna G. Manjón, Marcel de Haas, Ben Morris, Ruben Schep, Christ Leemans, Anoek Friskes, Roderick L. Beijersbergen, Mathijs A. Sanders, René H. Medema, Bas van Steensel
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract DNA double-strand breaks are repaired by multiple pathways, including non-homologous end-joining (NHEJ) and microhomology-mediated end-joining (MMEJ). The balance of these pathways is dependent on the local chromatin context, but the underly
Externí odkaz:
https://doaj.org/article/6009cbab086a43759a3f31b9c33c7f5d
Autor:
Anna G. Manjón, Stefano Giustino Manzo, Stefan Prekovic, Leon Potgeter, Tom van Schaik, Ning Qing Liu, Koen Flach, Daniel Peric-Hupkes, Stacey Joosten, Hans Teunissen, Anoek Friskes, Mila Ilic, Dorine Hintzen, Vinícius H. Franceschini-Santos, Wilbert Zwart, Elzo de Wit, Bas van Steensel, René H. Medema
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113124- (2023)
Summary: Acquired drug resistance is a major problem in the treatment of cancer. hTERT-immortalized, untransformed RPE-1 cells can acquire resistance to Taxol by derepressing the ABCB1 gene, encoding for the multidrug transporter P-gP. Here, we inves
Externí odkaz:
https://doaj.org/article/7a246652a6144b62a928cb9cb12c35f2
Autor:
Tom van Schaik, Ning Qing Liu, Stefano G. Manzo, Daan Peric-Hupkes, Elzo de Wit, Bas van Steensel
Publikováno v:
Genome Biology, Vol 23, Iss 1, Pp 1-26 (2022)
Abstract Background Lamina-associated domains (LADs) are large genomic regions that are positioned at the nuclear lamina. It has remained largely unclear what drives the positioning and demarcation of LADs. Because the insulator protein CTCF is enric
Externí odkaz:
https://doaj.org/article/b6ade8f819f9451eab87ce8b9171ce53
Autor:
Yuchuan Wang, Yang Zhang, Ruochi Zhang, Tom van Schaik, Liguo Zhang, Takayo Sasaki, Daniel Peric-Hupkes, Yu Chen, David M. Gilbert, Bas van Steensel, Andrew S. Belmont, Jian Ma
Publikováno v:
Genome Biology, Vol 22, Iss 1, Pp 1-23 (2021)
Abstract We report SPIN, an integrative computational method to reveal genome-wide intranuclear chromosome positioning and nuclear compartmentalization relative to multiple nuclear structures, which are pivotal for modulating genome function. As a pr
Externí odkaz:
https://doaj.org/article/e008eba1ec264243b115380d6b6da444
Publikováno v:
Frontiers in Genetics, Vol 12 (2022)
DNA double-strand breaks (DSBs) can be repaired through various pathways. Understanding how these pathways are regulated is of great interest for cancer research and optimization of gene editing. The local chromatin environment can affect the balance
Externí odkaz:
https://doaj.org/article/a8481d67b5f441f3a0e1700adb8f9a7d
Autor:
Melania Balzarolo, Sander Engels, Anja J. de Jong, Katka Franke, Timo K. van den Berg, Muhammet F. Gulen, Andrea Ablasser, Edith M. Janssen, Bas van Steensel, Monika C. Wolkers
Publikováno v:
Open Biology, Vol 11, Iss 3 (2021)
Nucleic acid sensing through pattern recognition receptors is critical for immune recognition of microbial infections. Microbial DNA is frequently methylated at the N6 position of adenines (m6A), a modification that is rare in mammalian host DNA.
Externí odkaz:
https://doaj.org/article/7352304321c146c295f01e205c0dafa9
Autor:
Alexey V. Pindyurin, Artem A. Ilyin, Anton V. Ivankin, Mikhail V. Tselebrovsky, Valentina V. Nenasheva, Elena A. Mikhaleva, Ludo Pagie, Bas van Steensel, Yuri Y. Shevelyov
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-17 (2018)
Abstract Background In most mammalian cell lines, chromatin located at the nuclear periphery is represented by condensed heterochromatin, as evidenced by microscopy observations and DamID mapping of lamina-associated domains (LADs) enriched in dimeth
Externí odkaz:
https://doaj.org/article/e3802e94a35041548c39dd288983ec3e
Autor:
Marco La Fortezza, Giovanna Grigolon, Andrea Cosolo, Alexey Pindyurin, Laura Breimann, Helmut Blum, Bas van Steensel, Anne-Kathrin Classen
Publikováno v:
Epigenetics & Chromatin, Vol 11, Iss 1, Pp 1-17 (2018)
Abstract Background Tracking dynamic protein–chromatin interactions in vivo is key to unravel transcriptional and epigenetic transitions in development and disease. However, limited availability and heterogeneous tissue composition of in vivo sourc
Externí odkaz:
https://doaj.org/article/fecbde0415004ffb893099b52309f598
Autor:
Tao Chen, Bas van Steensel
Publikováno v:
PLoS Genetics, Vol 13, Iss 8, p e1006929 (2017)
Eukaryotic mRNAs undergo a cycle of transcription, nuclear export, and degradation. A major challenge is to obtain a global, quantitative view of these processes. Here we measured the genome-wide nucleocytoplasmic dynamics of mRNA in Drosophila cells
Externí odkaz:
https://doaj.org/article/893f35eab82d46bf9a240aa5fdb73a8a
Autor:
Annalisa Izzo, Kinga Kamieniarz-Gdula, Fidel Ramírez, Nighat Noureen, Jop Kind, Thomas Manke, Bas van Steensel, Robert Schneider
Publikováno v:
Cell Reports, Vol 3, Iss 6, Pp 2142-2154 (2013)
Human cells contain five canonical, replication-dependent somatic histone H1 subtypes (H1.1, H1.2, H1.3, H1.4, and H1.5). Although they are key chromatin components, the genomic distribution of the H1 subtypes is still unknown, and their role in chro
Externí odkaz:
https://doaj.org/article/ae157c8ce19f4046b93876918e4ba3e0