Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Bas van Gerwen"'
Autor:
Stefano Annunziato, Julian R. de Ruiter, Linda Henneman, Chiara S. Brambillasca, Catrin Lutz, François Vaillant, Federica Ferrante, Anne Paulien Drenth, Eline van der Burg, Bjørn Siteur, Bas van Gerwen, Roebi de Bruijn, Martine H. van Miltenburg, Ivo J. Huijbers, Marieke van de Ven, Jane E. Visvader, Geoffrey J. Lindeman, Lodewyk F. A. Wessels, Jos Jonkers
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
It is difficult to identify cancer driver genes in cancers, for instance BRCA1 mutated breast cancer, that are characterised by large scale genomic alterations. Here, the authors develop genetically engineered mouse models of BRCA1-deficient breast c
Externí odkaz:
https://doaj.org/article/d9ac65cbd345403caaf37726c9a7d740
Autor:
Anne Paulien Drenth, Lukas E. Dow, Jinhyuk Bhin, Catrin Lutz, Jos Jonkers, Bjorn Siteur, Katharina Boroviak, David J. Adams, Marieke van de Ven, Emma M Schatoff, Maria Paz Zafra, Ivo J. Huijbers, Linda Henneman, Kim Wong, Stefano Annunziato, Siddhartha Mukherjee, Bas van Gerwen, Lodewyk F. A. Wessels, Timo Eijkman, Eline van der Burg, Renske de Korte-Grimmerink
Publikováno v:
The EMBO journal. 39(5)
Genetically engineered mouse models (GEMMs) of cancer have proven to be of great value for basic and translational research. Although CRISPR-based gene disruption offers a fast-track approach for perturbing gene function and circumvents certain limit
Autor:
Federica Ferrante, Anne Paulien Drenth, Ivo J. Huijbers, Marieke van de Ven, Jane E. Visvader, Julian R. de Ruiter, Chiara S. Brambillasca, Linda Henneman, Eline van der Burg, Bjorn Siteur, Roebi de Bruijn, François Vaillant, Catrin Lutz, Stefano Annunziato, Martine H. van Miltenburg, Bas van Gerwen, Lodewyk F. A. Wessels, Jos Jonkers, Geoffrey J. Lindeman
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
BRCA1-mutated breast cancer is primarily driven by DNA copy-number alterations (CNAs) containing large numbers of candidate driver genes. Validation of these candidates requires novel approaches for high-throughput in vivo perturbation of gene functi
Autor:
Rahmen Bin Ali, Micha Nethe, Ivo J. Huijbers, Sjors M. Kas, Bas van Gerwen, Mirjam C. Boelens, Marieke van de Ven, Martine H. van Miltenburg, Colin Pritchard, Jos Jonkers, Eva Schut, Stefano Annunziato, Hatice Yucel, Anne Paulien Drenth, Sjoerd Klarenbeek, Bjorn Siteur, Jessica Del Bravo
Large-scale sequencing studies are rapidly identifying putative oncogenic mutations in human tumors. However, discrimination between passenger and driver events in tumorigenesis remains challenging and requires in vivo validation studies in reliable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe721c4ef97c56684331eb2936541906
https://europepmc.org/articles/PMC4926868/
https://europepmc.org/articles/PMC4926868/
Autor:
Federica Ferrante, Bas van Gerwen, Catrin Lutz, Martine H. van Miltenburg, Chiara Svetlana Brambillasca, Stefano Annunziato, Marieke van de Ven, Sjors M. Kas, Bjorn Siteur, Jos Jonkers, Linda Henneman, Julian R. de Ruiter
Publikováno v:
Cancer Research. 78:A01-A01
Large-scale sequencing studies are rapidly identifying putative oncogenic mutations in human tumors. However, discrimination between passenger and driver events in tumorigenesis remains challenging and requires in vivo validation studies in reliable
Autor:
Sjoerd Klarenbeek, Jessica Del Bravo, Jos Jonkers, Bas van Gerwen, Ivo J. Huijbers, Stefano Annunziato, Colin C. Pritchard, Rahmen B. Ali, Bjorn Siteur, Anne Paulien Drenth, Sjors M. Kas, Hatice Yucel, Eva Schut-Kregel, Micha Nethe, Martine H. van Miltenburg
Publikováno v:
Cancer Research. 76:2687-2687
Invasive lobular carcinoma (ILC) is the second most common breast cancer subtype, accounting for 5% to 15% of breast tumors.The majority of ILCs are characterized by the complete loss of the cell adhesion protein E-cadherin encoded by the CDH1 gene.