Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Bas van Breukelen"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 9, p 7884 (2023)
Many essential cellular functions are carried out by multi-protein complexes that can be characterized by their protein–protein interactions. The interactions between protein subunits are critically dependent on the strengths of their interactions
Externí odkaz:
https://doaj.org/article/d61ecca73a30489588235bbc69ec6038
Autor:
Piero Giansanti, Thin Thin Aye, Henk van den Toorn, Mao Peng, Bas van Breukelen, Albert J.R. Heck
Publikováno v:
Cell Reports, Vol 11, Iss 11, Pp 1834-1843 (2015)
Although mass-spectrometry-based screens enable thousands of protein phosphorylation sites to be monitored simultaneously, they often do not cover important regulatory sites. Here, we hypothesized that this is due to the fact that nearly all large-sc
Externí odkaz:
https://doaj.org/article/c2890c92d94d48c5ab5052eac79c4454
Autor:
Marjon A Smit, Gianluca Maddalo, Kylie Greig, Linsey M Raaijmakers, Patricia A Possik, Bas van Breukelen, Salvatore Cappadona, Albert JR Heck, AF Maarten Altelaar, Daniel S Peeper
Publikováno v:
Molecular Systems Biology, Vol 10, Iss 12, Pp 1-15 (2014)
Abstract Treatment of BRAF mutant melanomas with specific BRAF inhibitors leads to tumor remission. However, most patients eventually relapse due to drug resistance. Therefore, we designed an integrated strategy using (phospho)proteomic and functiona
Externí odkaz:
https://doaj.org/article/29adb95d2eb0448bb24189c0b9582da9
Autor:
Teck Yew Low, Sebastiaan van Heesch, Henk van den Toorn, Piero Giansanti, Alba Cristobal, Pim Toonen, Sebastian Schafer, Norbert Hübner, Bas van Breukelen, Shabaz Mohammed, Edwin Cuppen, Albert J.R. Heck, Victor Guryev
Publikováno v:
Cell Reports, Vol 5, Iss 5, Pp 1469-1478 (2013)
Quantitative and qualitative protein characteristics are regulated at genomic, transcriptomic, and posttranscriptional levels. Here, we integrated in-depth transcriptome and proteome analyses of liver tissues from two rat strains to unravel the inter
Externí odkaz:
https://doaj.org/article/6b829f7ccf7a4454af8979171bb90d49
Autor:
Jos Boekhorst, Paul J Boersema, Bastiaan B J Tops, Bas van Breukelen, Albert J R Heck, Berend Snel
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23276 (2011)
Unraveling the functional dynamics of phosphorylation networks is a crucial step in understanding the way in which biological networks form a living cell. Recently there has been an enormous increase in the number of measured phosphorylation events.
Externí odkaz:
https://doaj.org/article/ae962c9391ae494fba7c3af2a1ad388b
Histidine-rich glycoprotein (HRG) is a liver-produced protein circulating in human serum at high concentrations of around 125 μg/mL. HRG belongs to the family of type-3 cystatins and has been implicated in a plethora of biological processes, albeit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edc983373cee585542cd3eeabef5087a
https://dspace.library.uu.nl/handle/1874/429358
https://dspace.library.uu.nl/handle/1874/429358
Autor:
Simona Grasso, Jan-Willem E. M. Sels, Ayse Nur Polat, Henk W. P. van den Toorn, Patrick Wijten, Andrew P. Stubbs, Bas van Breukelen, Salvatore Cappadona, Onno B. Bleijerveld, Arjen Scholten, Gerard Pasterkamp, Reinout Raijmakers, Elizabeth A. McClellan, Imo E. Hoefer, Loes Colle, Albert J. R. Heck
Publikováno v:
Journal of Proteome Research, 11(11), 5235-5244. American Chemical Society
Coronary atherosclerosis represents the major cause of death in Western societies. As atherosclerosis typically progresses over years without giving rise to clinical symptoms, biomarkers are urgently needed to identify patients at risk. Over the past
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c06b8b787efdeb1cb22df9a36bcb22
https://doi.org/10.1021/pr3004375
https://doi.org/10.1021/pr3004375
Publikováno v:
Amino Acids
Mass spectrometry-based proteomics has evolved as a high-throughput research field over the past decade. Significant advances in instrumentation, and the ability to produce huge volumes of data, have emphasized the need for adequate data analysis too
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce3934087b95662a454fa9f9c1862496
Autor:
Serena Tolin, Gian Paolo Fadini, Bas van Breukelen, Paolo Tessari, Renato Millioni, Marco Falda, Giorgio Arrigoni
Publikováno v:
Amino Acids. 43:2199-2202
Reducing the complexity of plasma proteome through complex multidimensional fractionation protocols is critical for the detection of low abundance proteins that have the potential to be the most specific disease biomarkers. Therefore, we examined a f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cdcf22866664b083f3b1a116df56ec5
https://doi.org/10.1007/s00726-012-1267-1
https://doi.org/10.1007/s00726-012-1267-1
Autor:
Henk W. P. van den Toorn, Juan Antonio Vizcaíno, Florian Reisinger, Henning Hermjakob, Rui Wang, David Ovelleiro, José A. Dianes, Attila Csordas, Harald Barsnes, James C. Wright, Niels Hulstaert, Albert J. R. Heck, Yasset Perez-Rivevol, Bas van Breukelen, Lennart Martens, Richard G. Côté, Johannes Griss
Publikováno v:
Molecular & Cellular Proteomics
Molecular & Cellular Proteomics; Vol 11
Molecular & Cellular Proteomics : MCP
Europe PubMed Central
Molecular & Cellular Proteomics; Vol 11
Molecular & Cellular Proteomics : MCP
Europe PubMed Central
The original PRIDE Converter tool greatly simplified the process of submitting mass spectrometry (MS)-based proteomics data to the PRIDE database. However, after much user feedback, it was noted that the tool had some limitations and could not handle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8742b6d15a3da11d0df06e938541adcb