Stable X Chromosome Reactivation in Female Human Induced Pluripotent Stem Cells

Autor: Tahsin Stefan Barakat, Mehrnaz Ghazvini, Bas de Hoon, Tracy Li, Bert Eussen, Hannie Douben, Reinier van der Linden, Nathalie van der Stap, Marjan Boter, Joop S. Laven, Robert-Jan Galjaard, J. Anton Grootegoed, Annelies de Klein, Joost Gribnau

Publikováno v: Stem Cell Reports, Vol 4, Iss 2, Pp 199-208 (2015)

In placental mammals, balanced expression of X-linked genes is accomplished by X chromosome inactivation (XCI) in female cells. In humans, random XCI is initiated early during embryonic development. To investigate whether reprogramming of female huma

Externí odkaz: https://doaj.org/article/65e2748f7a6c4655a09a3d0701890f98

Supplementary Methods from Impact of Intertumoral Heterogeneity on Predicting Chemotherapy Response of BRCA1-Deficient Mammary Tumors

Autor: Piet Borst, Jos Jonkers, Sabine C. Linn, Lodewyk Wessels, Joost Gribnau, Michael M. Gottesman, Jean-Pierre Gillet, Jelle Wesseling, Eline van der Burg, Wendy Sol, Martin Lodén, Martijn Jonkers, Janneke E. Jaspers, Marina Pajic, Serge A.L. Zander, Ariena Kersbergen, Philip C. Schouten, Jorma de Ronde, Bas de Hoon, Marieke A. Vollebergh, Sven Rottenberg

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Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92b5fb59b68bb787b02c87bd4aebfbb7
https://doi.org/10.1158/0008-5472.22393901

Data from Impact of Intertumoral Heterogeneity on Predicting Chemotherapy Response of BRCA1-Deficient Mammary Tumors

Autor: Piet Borst, Jos Jonkers, Sabine C. Linn, Lodewyk Wessels, Joost Gribnau, Michael M. Gottesman, Jean-Pierre Gillet, Jelle Wesseling, Eline van der Burg, Wendy Sol, Martin Lodén, Martijn Jonkers, Janneke E. Jaspers, Marina Pajic, Serge A.L. Zander, Ariena Kersbergen, Philip C. Schouten, Jorma de Ronde, Bas de Hoon, Marieke A. Vollebergh, Sven Rottenberg

The lack of markers to predict chemotherapy responses in patients poses a major handicap in cancer treatment. We searched for gene expression patterns that correlate with docetaxel or cisplatin response in a mouse model for breast cancer associated w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a0c8d513064f422a2bf489c0cb87ce26
https://doi.org/10.1158/0008-5472.c.6503906.v1

Pathogenic variants in E3 ubiquitin ligase RLIM/RNF12 lead to a syndromic X-linked intellectual disability and behavior disorder

Autor: Kees E. P. van Roozendaal, Molka Kammoun, Michael Field, Andreas Dufke, Joris Vermeesch, Annick Toutain, Hao Hu, Theresa Mihalic Mosher, Joep P.M. Geraedts, Hans-Hilger Ropers, Peter White, Jan Liebelt, Sungjin Moon, Vera M. Kalscheuer, Joost Gribnau, Bas de Hoon, Germán Rodríguez Criado, Marie Shaw, Ute Grasshoff, Stefan A. Haas, Benjamin J. Kelly, Lynne Hobson, Marjan De Rademaeker, Christelle Golzio, Suzanna G.M. Frints, Olaf Riess, Claudia S. Bauer, Eric Haan, Nicholas Katsanis, Peter Bauer, Karen W. Gripp, Renee Carroll, Jozef Gecz, Jean Pierre Fryns, Cristina Gontan, Aysegul Ozanturk, Eveline Rentmeester, Martine Raynaud, Scott E. Hickey, Daniel C. Koboldt, Sylvie Manouvrier-Hanu, Lucinda Murray, Koen Devriendt, Christopher Schroeder, Kathryn Friend

Publikováno v: Molecular Psychiatry, 24(11), 1748-1768. Nature Publishing Group
Molecular Psychiatry
Mol Psychiatry
Mol Psychiatry, 2019, 24 (11), pp.1748-1768. ⟨10.1038/s41380-018-0065-x⟩

RLIM, also known as RNF12, is an X-linked E3 ubiquitin ligase acting as a negative regulator of LIM-domain containing transcription factors and participates in X-chromosome inactivation (XCI) in mice. We report the genetic and clinical findings of 84

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f231093f4b0a28181fca8824d9e8f450
https://doi.org/10.1038/s41380-018-0065-x

Fitting the Puzzle Pieces: the Bigger Picture of XCI

Autor: Bas de Hoon, Cheryl Maduro, Joost Gribnau

Publikováno v: Trends in Biochemical Sciences, 41(2), 138-147. Elsevier Ltd.

X chromosome inactivation (XCI) is a mammalian-specific process initiated in all female cells, leading to one inactivated X chromosome. The robust nature of XCI, and the complex mechanisms involved in directing this process, makes XCI an important mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d2afe5747c337e4b97b8797fe877fe6
https://pure.eur.nl/en/publications/e3bc06e0-181f-4d16-9936-174d88bc6904