Bisphosphine-Functionalized Cyclic Decapeptides Based on the Natural Product Gramicidin S: A Potential Scaffold for Transition-Metal Coordination

Autor: Sander G. A. van Assema, J. Chris Slootweg, José M. Otero, Antonio L. Llamas-Saiz, Mark J. van Raaij, Mark Overhand, Bas Lastdrager, Koop Lammertsma, Sebastian Burck, Andreas W. Ehlers, Bruno Dacunha-Marinho

Publikováno v: Chemistry: A European Journal, 15(33), 8134-45. Wiley-VCH Verlag
Burck, S, van Assema, S G A, Lastdrager, B, Slootweg, J C, Ehlers, A W, Otero, J M, Dacunha-Marinho, B, Llamas-Saiz, A L, Overhand, M, van Raaij, M J & Lammertsma, K 2009, ' Bisphosphine-functionalized cyclic decapeptides based on the natural product Gramicidin S: a potential scaffold for transition-metal coordination ', Chemistry: A European Journal, vol. 15, no. 33, pp. 8134-45 . https://doi.org/10.1002/chem.200901127

The natural product Gramicidin S is a promising scaffold for novel oligopeptide-based bisphosphine ligands, combining the advantageous rigid chiral backbone with the close proximity of phosphine substituents. The required unnatural, phosphine-contain

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::191183838a19a293376f4bd28a15f45d
https://doi.org/10.1002/chem.200901127

Claisen self-condensation/decarboxylation as the key steps in the synthesis of C2-symmetrical 1,7-dioxaspiro[5.5]undecanes

Autor: Bas Lastdrager, Herman S. Overkleeft, Gijsbert A. van der Marel, Mattie S. M. Timmer

Publikováno v: Tetrahedron Letters. 46:6195-6198

A convenient method for the synthesis of functionalised 1,7-dioxaspiro[5.5]undecanes using acid-catalysed spiroketalisations of substituted dihydroxyketones is described. The dihydroxyketones were readily prepared from appropriately substituted hydro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3fab099fb1c531e4e3f3d7619d6a8c00
https://doi.org/10.1016/j.tetlet.2005.07.073

A stereoselective and efficient route to (3S, 4R, 5S)-(+)-4,5-dihydroxycyclopent-1-en-3-ylamine: the side chain of the hypermodified nucleoside Q

Autor: Bas Lastdrager, Gijsbert A. van der Marel, Jeroen D. C. Codée, Herman S. Overkleeft, Jacques H. van Boom, Huib Ovaa

Publikováno v: Tetrahedron Letters. 39:7987-7990

A stereoselective and high yielding route is described to a suitably protected derivative of (3S, 4R, 5S)-(+)-3-amino-4,5-dihydroxycyclopent-1-ene, the side chain moiety of queuosine. The synthetic route comprises a ring-closing metathesis (RCM) of a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3933d8b1a5a123d463525eed654a58f
https://doi.org/10.1016/s0040-4039(98)01738-9

ChemInform Abstract: A Versatile Approach to the Synthesis of Highly Functionalized Carbocycles

Autor: Huib Ovaa, Gijs A. van der Marel, Bas Lastdrager, Herman S. Overkleeft, Jeroen D. C. Codée, Jacques H. van Boom

Publikováno v: ChemInform. 30

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2158da9da524fc6e89f3d351bae4301a
https://doi.org/10.1002/chin.199939081

A Flexible Synthesis of Cyclopentitol Derivatives Based on Ring-Closing Metathesis of Carbohydrate-Derived 1,6-Dienes

Autor: Herman S. Overkleeft, Bas Lastdrager, Jeroen D. C. Codée, Huib Ovaa, Gijs A. van der Marel, Jacques H. van Boom

Publikováno v: ChemInform. 34

Four partially protected stereoisomeric cyclopentenetriols 5, 10, 15 and 21 have been prepared by ring-closing metathesis of carbohydrate-derived 1,6-dienes. The presence of a differentiated allylic alcohol in the cyclopentenetriols allows a variety

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c5c02de7efd3cd84c0763b89519a467
https://doi.org/10.1002/chin.200314204