Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins

Autor: Roman Belle, Jos J. A. G. Kamps, Jordi Poater, Kiran Kumar, Bas J. G. E. Pieters, Eidarus Salah, Timothy D. W. Claridge, Robert S. Paton, F. Matthias Bickelhaupt, Akane Kawamura, Christopher J. Schofield, Jasmin Mecinović

Publikováno v: Communications Chemistry, Vol 5, Iss 1, Pp 1-11 (2022)

N ε-methylation of lysine residues in histones plays an essential role in the regulation of eukaryotic transcription, and understanding the extent to which histone N ε-methyllysine readers and erasers can manifest selectivity is of fundamental and

Externí odkaz: https://doaj.org/article/099bbfd2e1894d158c026e859ca05b14

Mechanism of biomolecular recognition of trimethyllysine by the fluorinated aromatic cage of KDM5A PHD3 finger

Autor: Thijs Beuming, F. Matthias Bickelhaupt, Maud H. M. Wuts, Ger J. M. Pruijn, Jos J. A. G. Kamps, Jasmin Mecinović, Bas J. G. E. Pieters, Jordi Poater, Woody Sherman, Robert S. Paton, Kiran Kumar, Paul B. White

Publikováno v: Pieters, B J G E, Wuts, M H M, Poater, J, Kumar, K, White, P B, Kamps, J J A G, Sherman, W, Pruijn, G J M, Paton, R S, Beuming, T, Bickelhaupt, F M & Mecinović, J 2020, ' Mechanism of biomolecular recognition of trimethyllysine by the fluorinated aromatic cage of KDM5A PHD3 finger ', Communications Chemistry, vol. 3, no. 1, 69, pp. 1-12 . https://doi.org/10.1038/s42004-020-0313-2
Communications Chemistry, 3
Pieters, B J G E, Wuts, M H M, Poater, J, Kumar, K, White, P B, Kamps, J J A G, Sherman, W, Pruijn, G J M, Paton, R S, Beuming, T, Bickelhaupt, F M & Mecinović, J 2020, ' Mechanism of biomolecular recognition of trimethyllysine by the fluorinated aromatic cage of KDM5A PHD3 finger ', Communications Chemistry, vol. 3, 69 . https://doi.org/10.1038/s42004-020-0313-2
Communications Chemistry, 3(1):69, 1-12. Springer Nature
Communications Chemistry
Communications Chemistry, 3, 1
Communications Chemistry, Vol 3, Iss 1, Pp 1-12 (2020)

The understanding of biomolecular recognition of posttranslationally modified histone proteins is centrally important to the histone code hypothesis. Despite extensive binding and structural studies on the readout of histones, the molecular language

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10178b367b5719086ad0d3aa769b5e24
http://www.scopus.com/inward/record.url?scp=85085870921&partnerID=8YFLogxK

Installation of Trimethyllysine Analogs on Intact Histones via Cysteine Alkylation

Autor: Yvonne Grobben, Jordi C. J. Hintzen, Jasmin Mecinović, Bas J. G. E. Pieters, Jos J. A. G. Kamps, Abbas H. K. Al Temimi

Publikováno v: Pieters, B J G E, Hintzen, J C J, Grobben, Y, Temimi, A H K A, Kamps, J J A G & Mecinović, J 2019, ' Installation of Trimethyllysine Analogs on Intact Histones via Cysteine Alkylation ', Bioconjugate Chemistry, vol. 30, no. 3, pp. 952-958 . https://doi.org/10.1021/acs.bioconjchem.9b00065
Bioconjugate Chemistry

Site-specific incorporation of post-translationally modified amino acids into proteins, including histones, has been a subject of great interest for chemical and biochemical communities. Here, we describe a site-specific incorporation of structurally

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47d04cabcd081b6d034375bbc30e2d87
https://findresearcher.sdu.dk:8443/ws/files/150304886/Histone_alkylation_Pure.pdf

Recognition of shorter and longer trimethyllysine analogues by epigenetic reader proteins

Autor: F. Matthias Bickelhaupt, Peter Betlem, Roman Belle, Robert S. Paton, Jasmin Mecinović, Abbas H. K. Al Temimi, Kiran Kumar, Jordi Poater, Bas J. G. E. Pieters

Publikováno v: Chemical Communications, 54(19), 2409-2412. Royal Society of Chemistry
Chemical Communications, 54, 19, pp. 2409-2412
Chemical Communications
Al Temimi, A H K, Belle, R, Kumar, K, Poater, J, Betlem, P, Pieters, B J G E, Paton, R S, Bickelhaupt, F M & Mecinović, J 2018, ' Recognition of shorter and longer trimethyllysine analogues by epigenetic reader proteins ', Chemical Communications, vol. 54, no. 19, pp. 2409-2412 . https://doi.org/10.1039/c8cc01009a
Chemical Communications, 54, 2409-2412

Histone Nϵ-lysine methylation is a widespread posttranslational modification that is specifically recognised by a diverse class of Nϵ-methyllysine binding reader proteins. Combined thermodynamic data, molecular dynamics simulations, and quantum che

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a5eb982eef2c7853ae56be0a77fee8b
https://research.vu.nl/en/publications/3c04558c-15c1-4374-a9f4-9458c0dadb12

The effect of the length of histone h3k4me3 on recognition by reader proteins

Autor: Roman Belle, Jasmin Mecinović, Bas J. G. E. Pieters

Publikováno v: ChemBioChem, 14, 2408-12
ChemBioChem, 14, 18, pp. 2408-12

Item does not contain fulltext

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f1fe37831c39476a454c29ecbc342da
https://doi.org/10.1002/cbic.201300525