Profiling the polyadenylated transcriptome of extracellular vesicles with long-read nanopore sequencing.

Autor: Padilla, Juan-Carlos A.^1,2 (AUTHOR), Barutcu, Seda¹ (AUTHOR), Malet, Ludovic¹ (AUTHOR), Deschamps-Francoeur, Gabrielle¹ (AUTHOR), Calderon, Virginie¹ (AUTHOR), Kwon, Eunjeong¹ (AUTHOR), Lécuyer, Eric^1,2,3 (AUTHOR) eric.lecuyer@ircm.qc.ca

Publikováno v: BMC Genomics. 9/22/2023, Vol. 24 Issue 1, p1-16. 16p.

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Loss of Epigenetic Regulation Disrupts Lineage Integrity, Induces Aberrant Alveogenesis, and Promotes Breast Cancer.

Autor: Langille E; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Al-Zahrani KN; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada., Ma Z; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California., Liang M; Hospital for Sick Children, Toronto, Ontario, Canada., Uuskula-Reimand L; Hospital for Sick Children, Toronto, Ontario, Canada., Espin R; Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Oncobell, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain., Teng K; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Malik A; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Bergholtz H; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway., Ghamrasni SE; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Afiuni-Zadeh S; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada., Tsai R; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada., Alvi S; Hospital for Sick Children, Toronto, Ontario, Canada., Elia A; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Lü Y; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Oh RH; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Kozma KJ; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.; Hospital for Sick Children, Toronto, Ontario, Canada., Trcka D; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada., Narimatsu M; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada., Liu JC; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Nguyen T; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Barutcu S; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada., Loganathan SK; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada., Bremner R; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada., Bader GD; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Egan SE; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.; Hospital for Sick Children, Toronto, Ontario, Canada., Cescon DW; Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada., Sørlie T; Department of Cancer Genetics, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Wrana JL; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Jackson HW; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada., Wilson MD; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.; Hospital for Sick Children, Toronto, Ontario, Canada., Witkiewicz AK; Center for Personalized Medicine, Roswell Park Cancer Institute, Buffalo, New York., Knudsen ES; Center for Personalized Medicine, Roswell Park Cancer Institute, Buffalo, New York., Pujana MA; Program Against Cancer Therapeutic Resistance (ProCURE), Catalan Institute of Oncology (ICO), Oncobell, Bellvitge Institute for Biomedical Research (IDIBELL), L'Hospitalet del Llobregat, Barcelona, Spain., Wahl GM; Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, California., Schramek D; Centre for Molecular and Systems Biology, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada.; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada.

Publikováno v: Cancer discovery [Cancer Discov] 2022 Dec 02; Vol. 12 (12), pp. 2930-2953.