Zobrazeno 1 - 10
of 84
pro vyhledávání: '"Bartosz Wojtas"'
Autor:
Malgorzata Perycz, Michal J. Dabrowski, Marta Jardanowska-Kotuniak, Adria-Jaume Roura, Bartlomiej Gielniewski, Karolina Stepniak, Michał Dramiński, Iwona A. Ciechomska, Bozena Kaminska, Bartosz Wojtas
Publikováno v:
Acta Neuropathologica Communications, Vol 12, Iss 1, Pp 1-29 (2024)
Abstract The RE1-silencing transcription factor (REST) acts either as a repressor or activator of transcription depending on the genomic and cellular context. REST is a key player in brain cell differentiation by inducing chromatin modifications, inc
Externí odkaz:
https://doaj.org/article/9e43803f2e9b471f8242922568240305
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-12 (2023)
Abstract Most of anti-tumour therapies eliminate neoplastic cells by introducing DNA damage which ultimately triggers cell death. These effects are counteracted by activated DNA repair pathways to sustain tumour proliferation capacity. RECQL helicase
Externí odkaz:
https://doaj.org/article/5dd9b8f3862347d98f96346d2d2ff852
Autor:
Adria-Jaume Roura, Paulina Szadkowska, Katarzyna Poleszak, Michal J. Dabrowski, Aleksandra Ellert-Miklaszewska, Kamil Wojnicki, Iwona A. Ciechomska, Karolina Stepniak, Bozena Kaminska, Bartosz Wojtas
Publikováno v:
Clinical Epigenetics, Vol 15, Iss 1, Pp 1-22 (2023)
Abstract Background Glioblastoma (GBM, WHO grade IV) is an aggressive, primary brain tumor. Despite extensive tumor resection followed by radio- and chemotherapy, life expectancy of GBM patients did not improve over decades. Several studies reported
Externí odkaz:
https://doaj.org/article/7137ac18dafd4e8eaf59d8af42507495
Autor:
Iwona A. Ciechomska, Kamil Wojnicki, Bartosz Wojtas, Paulina Szadkowska, Katarzyna Poleszak, Beata Kaza, Kinga Jaskula, Wiktoria Dawidczyk, Ryszard Czepko, Mariusz Banach, Bartosz Czapski, Pawel Nauman, Katarzyna Kotulska, Wieslawa Grajkowska, Marcin Roszkowski, Tomasz Czernicki, Andrzej Marchel, Bozena Kaminska
Publikováno v:
Cancers, Vol 15, Iss 5, p 1562 (2023)
Glioblastomas (GBM) are the most common, primary brain tumors in adults. Despite advances in neurosurgery and radio- and chemotherapy, the median survival of GBM patients is 15 months. Recent large-scale genomic, transcriptomic and epigenetic analyse
Externí odkaz:
https://doaj.org/article/3caac37a22a84c1aa37b585f99d2b4f3
Autor:
Iwona Anna Ciechomska, Bartlomiej Gielniewski, Bartosz Wojtas, Bozena Kaminska, Jakub Mieczkowski
Publikováno v:
Experimental and Molecular Medicine, Vol 52, Iss 8, Pp 1326-1340 (2020)
Brain cancer: Stem cell properties may determine chemotherapy success The properties of individual glioma stem cells (GSCs) may influence the success of chemotherapy in tackling aggressive brain cancer. GSCs promote tumor growth and chemotherapy resi
Externí odkaz:
https://doaj.org/article/326a5025eb254efcb4e7bd10c5606d5a
Autor:
Natalia Vydra, Patryk Janus, Paweł Kus, Tomasz Stokowy, Katarzyna Mrowiec, Agnieszka Toma-Jonik, Aleksandra Krzywon, Alexander Jorge Cortez, Bartosz Wojtas, Bartłomiej Gielniewski, Roman Jaksik, Marek Kimmel, Wieslawa Widlak
Publikováno v:
eLife, Vol 10 (2021)
Heat shock factor 1 (HSF1), a key regulator of transcriptional responses to proteotoxic stress, was linked to estrogen (E2) signaling through estrogen receptor α (ERα). We found that an HSF1 deficiency may decrease ERα level, attenuate the mitogen
Externí odkaz:
https://doaj.org/article/383a16ae1226499da6110cc7bdacd864
Autor:
Maria Łastowska, Joanna Trubicka, Anna Sobocińska, Bartosz Wojtas, Magdalena Niemira, Anna Szałkowska, Adam Krętowski, Agnieszka Karkucińska-Więckowska, Magdalena Kaleta, Maria Ejmont, Marta Perek-Polnik, Bożenna Dembowska-Bagińska, Wiesława Grajkowska, Ewa Matyja
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-14 (2020)
Abstract Four molecular types of rare central nervous system (CNS) tumors have been recently identified by gene methylation profiling: CNS Neuroblastoma with FOXR2 activation (CNS NB-FOXR2), CNS Ewing Sarcoma Family Tumor with CIC alteration (CNS EFT
Externí odkaz:
https://doaj.org/article/2e546f93b82242a08cc7a0821eda5563
Autor:
Paulina Szadkowska, Adria-Jaume Roura, Bartosz Wojtas, Kamil Wojnicki, Sabina Licholai, Tomasz Waller, Tomasz Gubala, Kacper Zukowski, Michal Karpeta, Kinga Wilkus, Wojciech Kaspera, Sergiusz Nawrocki, Bozena Kaminska
Publikováno v:
Cancers, Vol 14, Iss 16, p 3902 (2022)
Malignant gliomas are the most frequent primary brain tumors in adults. They are genetically heterogenous and invariably recur due to incomplete surgery and therapy resistance. Circulating tumor DNA (ctDNA) is a component of circulating cell-free DNA
Externí odkaz:
https://doaj.org/article/ca4911528a0f40ae815e69b57e2befa7
Histone deacetylase inhibitors exert anti-tumor effects on human adherent and stem-like glioma cells
Autor:
Halina Was, Sylwia K. Krol, Dante Rotili, Antonello Mai, Bartosz Wojtas, Bozena Kaminska, Marta Maleszewska
Publikováno v:
Clinical Epigenetics, Vol 11, Iss 1, Pp 1-13 (2019)
Abstract Background The diagnosis of glioblastoma (GBM), a most aggressive primary brain tumor with a median survival of 14.6 months, carries a dismal prognosis. GBMs are characterized by numerous genetic and epigenetic alterations, affecting patient
Externí odkaz:
https://doaj.org/article/1c6a1218caa043ef980b945a3b4d8e3e
Autor:
Wenson D. Rajan, Bartosz Wojtas, Bartlomiej Gielniewski, Francesc Miró-Mur, Jordi Pedragosa, Malgorzata Zawadzka, Paulina Pilanc, Anna M. Planas, Bozena Kaminska
Publikováno v:
Neurobiology of Disease, Vol 137, Iss , Pp 104722- (2020)
Central nervous system (CNS)-border associated macrophages (BAMs) maintain their steady-state population during adulthood and are not replaced by circulating monocytes under physiological conditions. Their roles in CNS integrity and functions under p
Externí odkaz:
https://doaj.org/article/780649d76e204882895a69ff0ac3d302