Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Bartosz Wawrzynow"'
Autor:
Milena Wiech, Maciej B. Olszewski, Zuzanna Tracz-Gaszewska, Bartosz Wawrzynow, Maciej Zylicz, Alicja Zylicz
Publikováno v:
PLoS ONE, Vol 8, Iss 8 (2013)
Externí odkaz:
https://doaj.org/article/6f538a4cb6ff4c71ab9fe1837caff967
Autor:
Milena Wiech, Maciej B Olszewski, Zuzanna Tracz-Gaszewska, Bartosz Wawrzynow, Maciej Zylicz, Alicja Zylicz
Publikováno v:
PLoS ONE, Vol 7, Iss 12, p e51426 (2012)
Numerous p53 missense mutations possess gain-of-function activities. Studies in mouse models have demonstrated that the stabilization of p53 R172H (R175H in human) mutant protein, by currently unknown factors, is a prerequisite for its oncogenic gain
Externí odkaz:
https://doaj.org/article/3c0d7f067b7448d8a5adb06ecb1fc2ce
Autor:
Bartosz Wawrzynow, Marcin Herok, Marta J Maluszek, Maciej B. Olszewski, Maciej Zylicz, Alicja Zylicz
Publikováno v:
Cancers
Volume 13
Issue 18
Cancers, Vol 13, Iss 4501, p 4501 (2021)
Volume 13
Issue 18
Cancers, Vol 13, Iss 4501, p 4501 (2021)
Simple Summary MDM2 is a protein responsible for negative regulation of the p53 tumor suppressor. In addition, MDM2 exhibits chaperone-like properties similar to the HSP90 molecular chaperone. Multiple studies revealed that MDM2 is deeply involved in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0ddda7d3af49d0a4bd179b729803244
https://pubmed.ncbi.nlm.nih.gov/34572735
https://pubmed.ncbi.nlm.nih.gov/34572735
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer. 1869:161-174
Organized networks of heat shock proteins, which possess molecular chaperone activity, protect cells from abrupt environmental changes. Additionally, molecular chaperones are essential during stress-free periods, where they moderate housekeeping func
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb502dbf2e247e29a2ecdd04e4fd14c7
https://doi.org/10.1016/j.bbcan.2017.12.004
https://doi.org/10.1016/j.bbcan.2017.12.004
Autor:
Zuzanna Tracz-Gaszewska, Marcin Herok, Marcin Kosinski, Marta Klimczak, Przemyslaw Biecek, Bartosz Wawrzynow, Milena Wiech, Patrycja Czerwińska, Maciej Wiznerowicz, Alicja Zylicz, Maciej B. Olszewski, Maciej Zylicz
Publikováno v:
Oncotarget. 8:82123-82143
Utilizing the TCGA PANCAN12 dataset we discovered that cancer patients with mutations in TP53 tumor suppressor and overexpression of MDM2 oncogene exhibited decreased survival post treatment. Interestingly, in the case of breast cancer patients, this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dac18af240dfe03e7fe9f76e11652c86
https://doi.org/10.18632/oncotarget.18899
https://doi.org/10.18632/oncotarget.18899
Autor:
Zuzanna, Tracz-Gaszewska, Marta, Klimczak, Przemyslaw, Biecek, Marcin, Herok, Marcin, Kosinski, Maciej B, Olszewski, Patrycja, Czerwińska, Milena, Wiech, Maciej, Wiznerowicz, Alicja, Zylicz, Maciej, Zylicz, Bartosz, Wawrzynow
Publikováno v:
Oncotarget
Utilizing the TCGA PANCAN12 dataset we discovered that cancer patients with mutations in TP53 tumor suppressor and overexpression of MDM2 oncogene exhibited decreased survival post treatment. Interestingly, in the case of breast cancer patients, this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5b9b7fe5ea45a69b60c9ac9223cb5293
https://pubmed.ncbi.nlm.nih.gov/29137250
https://pubmed.ncbi.nlm.nih.gov/29137250
Autor:
Susanne Pettersson, Janice Bramham, Bartosz Wawrzynow, Alicja Zylicz, Kathryn L. Ball, Erin G. Worrall, Ted R. Hupp
Publikováno v:
Wawrzynow, B, Pettersson, S, Zylicz, A, Bramham, J, Worrall, E, Hupp, T R & Ball, K L 2009, ' A Function for the RING Finger Domain in the Allosteric Control of MDM2 Conformation and Activity ', Journal of Biological Chemistry, vol. 284, no. 17, pp. 11517-11530 . https://doi.org/10.1074/jbc.M809294200
The MDM2 oncoprotein plays multiple regulatory roles in the control of p53-dependent gene expression. A picture of MDM2 is emerging where structurally discrete but interdependent functional domains are linked through changes in conformation. The doma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1936e5af2fdd5fd43543de975d417843
https://doi.org/10.1074/jbc.m809294200
https://doi.org/10.1074/jbc.m809294200
Autor:
Kathryn L. Ball, Bartosz Wawrzynow, Craig Stevens, Susanne Pettersson, Maura Wallace, Alicja Zylicz, Ted R. Hupp
Publikováno v:
FEBS Journal. 275:4875-4886
Murine double minute 2 (MDM2) protein exhibits many diverse biochemical functions on the tumour suppressor protein p53, including transcriptional suppression and E3 ubiquitin ligase activity. However, more recent data have shown that MDM2 can exhibit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2eb4f8e2bbc3e283e3028569e87c7cfa
https://doi.org/10.1111/j.1742-4658.2008.06627.x
https://doi.org/10.1111/j.1742-4658.2008.06627.x
Publikováno v:
Journal of Biological Chemistry. 282:32603-32612
The murine double minute (mdm2) gene encodes an E3 ubiquitin ligase that plays a key role in the degradation of p53 tumor suppressor protein. Nevertheless recent data highlight other p53-independent functions of MDM2. Given that MDM2 protein binds AT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::245e7ddd8f246d48131387732f58ccab
https://doi.org/10.1074/jbc.m702767200
https://doi.org/10.1074/jbc.m702767200
Autor:
Joanna Boros, Maciej Zylicz, Grzegorz Kudla, Dawid Walerych, Frank W. King, Lin Müller, Alicja Zylicz, Bartosz Wawrzynow, Malgorzata Gutkowska, Aleksandra Helwak
Publikováno v:
Journal of Biological Chemistry. 279:48836-48845
Immortalized human fibroblasts were used to investigate the putative interactions of the Hsp90 molecular chaperone with the wild-type p53 tumor suppressor protein. We show that geldanamycin or radicicol, specific inhibitors of Hsp90, diminish specifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebfa5abe864f61ee0fea610585b4ac7d
https://doi.org/10.1074/jbc.m407601200
https://doi.org/10.1074/jbc.m407601200