Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Bartosz Tarkowski"'
Autor:
Michał Brouze, Agnieszka Czarnocka-Cieciura, Olga Gewartowska, Monika Kusio-Kobiałka, Kamil Jachacy, Marcin Szpila, Bartosz Tarkowski, Jakub Gruchota, Paweł Krawczyk, Seweryn Mroczek, Ewa Borsuk, Andrzej Dziembowski
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Cytoplasmic polyadenylation plays a vital role in gametogenesis; however, the participating enzymes and substrates in mammals remain unclear. Using knockout and knock-in mouse models, we describe the essential role of four TENT5 poly(A) poly
Externí odkaz:
https://doaj.org/article/8da351a5408d442a850de28038fde70e
Autor:
Aleksandra Bilska, Monika Kusio-Kobiałka, Paweł S. Krawczyk, Olga Gewartowska, Bartosz Tarkowski, Kamil Kobyłecki, Dominika Nowis, Jakub Golab, Jakub Gruchota, Ewa Borsuk, Andrzej Dziembowski, Seweryn Mroczek
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Regulating polyadenylation is important for mRNA stability, which can in turn affect B cell maturation and humoral immune responses. Here the authors use Nanopore poly(A) sequencing to explore the importance of the cytoplasmic poly(A) polymerase TENT
Externí odkaz:
https://doaj.org/article/cc7369751a0649a8ac0d65c96e3806d5
Autor:
Olga Gewartowska, Goretti Aranaz-Novaliches, Paweł S. Krawczyk, Seweryn Mroczek, Monika Kusio-Kobiałka, Bartosz Tarkowski, Frantisek Spoutil, Oldrich Benada, Olga Kofroňová, Piotr Szwedziak, Dominik Cysewski, Jakub Gruchota, Marcin Szpila, Aleksander Chlebowski, Radislav Sedlacek, Jan Prochazka, Andrzej Dziembowski
Publikováno v:
Cell Reports, Vol 35, Iss 3, Pp 109015- (2021)
Summary: Osteoblasts orchestrate bone formation through the secretion of type I collagen and other constituents of the matrix on which hydroxyapatite crystals mineralize. Here, we show that TENT5A, whose mutations were found in congenital bone diseas
Externí odkaz:
https://doaj.org/article/72264ef180444effa54deb1100b552fa
Autor:
Ines Jeric, Gabriele Maurer, Anna Lina Cavallo, Josipa Raguz, Enrico Desideri, Bartosz Tarkowski, Matthias Parrini, Irmgard Fischer, Kurt Zatloukal, Manuela Baccarini
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The kinase RAF1 usually exerts pro-tumorigenic functions promoting proliferation in RAS-driven cancers. Here, the authors using a mouse model of HCC and clinical data describe an unexpected oncosuppressor role of RAF1 in hepatocarcinoma development l
Externí odkaz:
https://doaj.org/article/5bc4b495b6cf4f9894441a93a6563ceb
Autor:
Matylda Macias, Magdalena Blazejczyk, Paulina Kazmierska, Bartosz Caban, Agnieszka Skalecka, Bartosz Tarkowski, Anna Rodo, Jan Konopacki, Jacek Jaworski
Publikováno v:
PLoS ONE, Vol 8, Iss 5, p e64455 (2013)
Mammalian target of rapamycin (mTOR) is a protein kinase that senses nutrient availability, trophic factors support, cellular energy level, cellular stress, and neurotransmitters and adjusts cellular metabolism accordingly. Adequate mTOR activity is
Externí odkaz:
https://doaj.org/article/f4082017b5e4443fb539dfecdb2c6876
Autor:
Paweł S Krawczyk, Olga Gewartowska, Michał Mazur, Wiktoria Orzeł, Katarzyna Matylla-Kulińska, Sebastian Jeleń, Paweł Turowski, Tomasz Śpiewla, Bartosz Tarkowski, Agnieszka Tudek, Aleksandra Brouze, Aleksandra Wesołowska, Dominika Nowis, Jakub Gołąb, Joanna Kowalska, Jacek Jemielity, Andrzej Dziembowski, Seweryn Mroczek
Though mRNA vaccines against COVID-19 have revolutionized vaccinology and have been administered in billions of doses, we know incredibly little about how mRNA vaccines are metabolizedin vivo. Here we implemented enhanced nanopore Direct RNA sequenci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5433e62b4ff352e3cb1129694b9a9339
https://doi.org/10.1101/2022.12.01.518149
https://doi.org/10.1101/2022.12.01.518149
Autor:
Aleksander Chlebowski, Goretti Aranaz-Novaliches, Olga Kofroňová, Oldrich Benada, Andrzej Dziembowski, Monika Kusio-Kobiałka, Dominik Cysewski, Radislav Sedlacek, Jan Prochazka, Bartosz Tarkowski, Olga Gewartowska, Pawel S. Krawczyk, Marcin Szpila, Piotr Szwedziak, Frantisek Spoutil, Jakub Gruchota, Seweryn Mroczek
Publikováno v:
Cell Reports, Vol 35, Iss 3, Pp 109015-(2021)
Summary: Osteoblasts orchestrate bone formation through the secretion of type I collagen and other constituents of the matrix on which hydroxyapatite crystals mineralize. Here, we show that TENT5A, whose mutations were found in congenital bone diseas
Publikováno v:
Human Molecular Genetics. 28:2107-2119
Several mosaic mutations of the mammalian/mechanistic target of rapamycin (mTOR) have recently been found in patients with cortical malformations, such as hemimegalencephaly (HME) and focal cortical dysplasia (FCD). Although all of them should activa
Autor:
Seweryn Mroczek, Goretti Aranaz Novaliches, Bartosz Tarkowski, Olga Kofroňová, Marcin Szpila, Andrzej Dziembowski, Oldrich Benada, Monika Kusio-Kobiałka, Dominik Cysewski, Olga Gewartowska, Piotr Szwedziak, Jakub Gruchota, Frantisek Spoutil, Pawel S. Krawczyk, Radislav Sedlacek, Aleksander Chlebowski, Jan Prochazka
Osteoblasts orchestrate bone formation by secreting dense, highly cross-linked type I collagen and other proteins involved in osteogenesis. Mutations in Col1α1, Col1α2, or collagen biogenesis factors lead to the human genetic disease, osteogenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df644eadf4e92918e035ba4159e84a0b
https://doi.org/10.1101/2020.08.18.256115
https://doi.org/10.1101/2020.08.18.256115
Autor:
Justyna Zmorzynska, Jacek Jaworski, Bartosz Tarkowski, Anna R. Malik, Aleksandra Tempes, Ewa Liszewska, Alicja Koscielny
Publikováno v:
Molecular Neurobiology
The formation of dendritic arbors in neurons is a highly regulated process. Among the regulators of dendritogenesis are numerous membrane proteins that are eventually internalized via clathrin-mediated endocytosis. AP2 is an adaptor complex that is r