Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Bartosz J Zieba"'
The actin associated protein palladin is important for the early smooth muscle cell differentiation.
Autor:
Li Jin, Qiong Gan, Bartosz J Zieba, Silvia M Goicoechea, Gary K Owens, Carol A Otey, Avril V Somlyo
Publikováno v:
PLoS ONE, Vol 5, Iss 9, p e12823 (2010)
Palladin, an actin associated protein, plays a significant role in regulating cell adhesion and cell motility. Palladin is important for development, as knockdown in mice is embryonic lethal, yet its role in the development of the vasculature is unkn
Externí odkaz:
https://doaj.org/article/e1398857d3cf4bd9a06bec59d3b8fdef
Autor:
Katarzyna Guzik, Przemyslaw Grudnik, Bartosz J. Zieba, Krzysztof M. Zak, Grzegorz Dubin, Bogdan Musielak, Alexander Dömling, Tad A. Holak
Publikováno v:
Oncotarget
Oncotarget, 7(21), 30323-30335. Impact Journals LLC
Oncotarget, 7(21), 30323-30335. Impact Journals LLC
Targeting the PD-1/PD-L1 immunologic checkpoint with monoclonal antibodies has provided unprecedented results in cancer treatment in the recent years. Development of chemical inhibitors for this pathway lags the antibody development because of insuff
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4077c489c1a3e54f918f43d3ca7d076c
https://hdl.handle.net/11370/66b38ebe-19cb-4ca3-bd38-d873a99853be
https://hdl.handle.net/11370/66b38ebe-19cb-4ca3-bd38-d873a99853be
Autor:
Bartosz J. Zieba, Grzegorz Dubin, Michael Sattler, Marcin Tomala, Lukasz Skalniak, Katarzyna Magiera-Mularz, Sylwia Krzanik, Tad A. Holak, Bogdan Musielak, Marcin Pustula, Grzegorz M. Popowicz, Katarzyna Kubica
Publikováno v:
Eur. J. Med. Chem. 150, 261-267 (2018)
USP2a is a deubiquitinating protease that rescues its target proteins from destruction by the proteasome by reversing the process of protein ubiquitination. USP2a shows oncogenic properties in vivo and has been found to be a specific activator of cyc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1098ce0b05127450a2f7b2d8cff57211
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=53237
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=53237
Autor:
Zhi-Dong Ge, David X. Zhang, Hayley Lund, Sribalaji Lakshmikanthan, Avril V. Somlyo, Bartosz J. Zieba, Xiaodong Zheng, David L. Mattson, Ko Momotani, John A. Auchampach, Mykhaylo V. Artamonov, Aniko Szabo, Jason E. Maas, Magdalena Chrzanowska-Wodnicka
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 34:1486-1494
Objective— Small GTPase Ras-related protein 1 (Rap1b) controls several basic cellular phenomena, and its deletion in mice leads to several cardiovascular defects, including impaired adhesion of blood cells and defective angiogenesis. We found that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85da3fa4ef43c485637767ad2b2fd076
https://doi.org/10.1161/atvbaha.114.303678
https://doi.org/10.1161/atvbaha.114.303678
Autor:
Thomas E. Barta, Cindy Sutherland, Laura Hagerty, Timothy A.J. Haystead, Douglas H. Weitzel, Philip F. Hughes, Avril V. Somlyo, Christopher N. Fortner, James Marvin Veal, Brittany L. Speer, Jing Ti Deng, Bartosz J. Zieba, Justin A. MacDonald, Aaron S. Franke, Michael P. Walsh, David A. Carlson
Publikováno v:
ACS Chemical Biology. 8:2715-2723
DAPK1 and ZIPK (also called DAPK3) are closely related serine/threonine protein kinases that regulate programmed cell death and phosphorylation of non-muscle and smooth muscle myosin. We have developed a fluorescence linked enzyme chemoproteomic stra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1368f024dd488bafab114d019b552fe9
https://doi.org/10.1021/cb400407c
https://doi.org/10.1021/cb400407c
Autor:
Katarzyna Kubica, Marcin Les, Marcin Tomala, Neli Kachamakova-Trojanowska, Bartosz J. Zieba, Katarzyna Magiera, Tad A. Holak, Lukasz Skalniak, Virginia De Cesare, Grzegorz Dubin, Matthias Trost
Publikováno v:
Cell Chemical Biology. 24:458-470.e18
USP2a is a deubiquitinase responsible for stabilization of cyclin D1, a crucial regulator of cell-cycle progression and a proto-oncoprotein overexpressed in numerous cancer types. Here we report that lithocholic acid (LCA) derivatives are inhibitors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d43147e41ad651b4abb5939fcd379b9
https://doi.org/10.1016/j.chembiol.2017.03.002
https://doi.org/10.1016/j.chembiol.2017.03.002
Autor:
John A. Auchampach, Avril V. Somlyo, Zhi-Dong Ge, David X. Zhang, Hayley Lund, Sribalaji Lakshmikanthan, Yoshinori Nishijima, David L. Mattson, Aniko Szabo, Jason E. Maas, Bartosz J. Zieba, Jeannette Vasquez-Vivar, Xiaodong Zheng, Ko Momotani, Magdalena Chrzanowska-Wodnicka
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 33
Smooth muscle (SM)-mediated vessel contraction and endothelium-dependent vessel dilation are major mechanisms controlling basal vascular tone. Increased vascular tone leads to arterial hypertension, a risk factor for cardiovascular diseases. Agonist-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37f54b72925b11497f364cac922ad956
https://doi.org/10.1161/atvb.33.suppl_1.a206
https://doi.org/10.1161/atvb.33.suppl_1.a206
Autor:
Alexander S. Khromov, Andra S. Stevenson, Ruoya Ho, Aaron S. Franke, Bartosz J. Zieba, Magdalena Chrzanowska-Wodnicka, Ko Momotani, Li Jin, Avril V. Somlyo, Ronald L. Neppl, Mykhaylo V. Artamonov
Publikováno v:
The FASEB Journal. 25
Agonist activation of the small GTPase, RhoA, and its effector Rho kinase leads to down-regulation of smooth muscle (SM) myosin light chain phosphatase activity, an increase in myosin light chain (RLC20) phosphorylation and force. Cyclic nucleotides
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6f43d37e76b0bbe71d24a3082bd53c11
https://doi.org/10.1096/fasebj.25.1_supplement.1115.17
https://doi.org/10.1096/fasebj.25.1_supplement.1115.17
Autor:
Magdalena Chrzanowska-Wodnicka, Mykhaylo V. Artamonov, Li Jin, Avril V. Somlyo, Ko Momotani, Ronald L. Neppl, Bartosz J. Zieba, Alexander S. Khromov, Aaron S. Franke, Ruoya Ho, Andra S. Stevenson
Agonist activation of the small GTPase, RhoA, and its effector Rho kinase leads to down-regulation of smooth muscle (SM) myosin light chain phosphatase activity, an increase in myosin light chain (RLC(20)) phosphorylation and force. Cyclic nucleotide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3a7646900d458bc0f1862b6413c3fcb
https://europepmc.org/articles/PMC3089510/
https://europepmc.org/articles/PMC3089510/
Autor:
Gary K. Owens, Silvia M. Goicoechea, Bartosz J. Zieba, Li Jin, Avril V. Somlyo, Carol A. Otey, Qiong Gan
Publikováno v:
PLoS ONE
PLoS ONE, Vol 5, Iss 9, p e12823 (2010)
PLoS ONE, Vol 5, Iss 9, p e12823 (2010)
Palladin, an actin associated protein, plays a significant role in regulating cell adhesion and cell motility. Palladin is important for development, as knockdown in mice is embryonic lethal, yet its role in the development of the vasculature is unkn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::256365c9f32ad499bb0a192b675a334e