Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Bartosz Balana"'
Autor:
Bartosz Balana, Laia Bahima, Karthik Bodhinathan, Jaume J Taura, Natalie M Taylor, Margaret Y Nettleton, Francisco Ciruela, Paul A Slesinger
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e59800 (2013)
G protein-gated inwardly rectifying potassium (GIRK) channels play an important role in regulating neuronal excitability. Sorting nexin 27b (SNX27b), which reduces surface expression of GIRK channels through a PDZ domain interaction, contains a putat
Externí odkaz:
https://doaj.org/article/35914bce9f0d406eb03d3d055acbe8c2
Autor:
Christine F. Gelin, Brice Stenne, Heather Coate, Afton Hiscox, Akinola Soyode-Johnson, Jessica L. Wall, Brian Lord, Jeffrey Schoellerman, Kevin J. Coe, Kai Wang, Jesus Alcázar, Christa C. Chrovian, Curt A. Dvorak, Nicholas I. Carruthers, Tatiana Koudriakova, Bartosz Balana, Michael A. Letavic
Publikováno v:
Journal of Medicinal Chemistry. 66:2877-2892
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e473bb48ba527d136d4062091035bc17
https://doi.org/10.1021/acs.jmedchem.2c01916
https://doi.org/10.1021/acs.jmedchem.2c01916
Autor:
Alexandra S Needham, Akinola Soyode-Johnson, Kevin J. Coe, Bartosz Balana, Freddy Schoetens, Xiaohui Jiang, Daniel J. Pippel, Kia Sepassi, Chungfang Xia, Stenne Brice M, Brian Scott, Leslie Nguyen, Tatiana Koudriakova, Christa C. Chrovian, Brian Lord, Michael A. Letavic, Jeffrey Schoellerman
Publikováno v:
Journal of Medicinal Chemistry. 63:9181-9196
Selective inhibitors of the GluN2B subunit of N-methyl-d-aspartate receptors in the ionotropic glutamate receptor superfamily have been targeted for the treatment of mood disorders. We sought to identify structurally novel, brain penetrant, GluN2B-se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19f1743cefc51ebca30728bea44390f7
https://doi.org/10.1021/acs.jmedchem.9b02113
https://doi.org/10.1021/acs.jmedchem.9b02113
Autor:
Akinola Soyode-Johnson, Michael A. Letavic, Kevin J. Coe, Christa C. Chrovian, Brian Lord, Nicholas I. Carruthers, Wall Jessica L, Bartosz Balana, Xiaohui Jiang, Tatiana Koudriakova, Leslie Nguyen, Jason C. Rech, Jeff Schoellerman
Publikováno v:
ACS Medicinal Chemistry Letters. 10:261-266
Herein, we disclose a series of selective GluN2B negative allosteric modulators containing a 1H-pyrrolo[3,2-b]pyridine core. Lead optimization efforts included increasing brain penetration as well as decreasing cytochrome P450 inhibition and hERG cha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::614ed6a6c02beecc62fce4553e7a6304
https://doi.org/10.1021/acsmedchemlett.8b00542
https://doi.org/10.1021/acsmedchemlett.8b00542
Autor:
Jose A. Matta, Natalie Welty, Pascal Bonaventure, Anindya Bhattacharya, Tim Lovenberg, Ryan M Wyatt, Jeffrey Schoellerman, Bartosz Balana, Robert A. Neff, Brian Lord, Michael A. Letavic
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::97159a8c562437988dbc59b2cef62a55
https://doi.org/10.1096/fasebj.2020.34.s1.02535
https://doi.org/10.1096/fasebj.2020.34.s1.02535
Autor:
Michael A. Letavic, Tim Lovenberg, Bartosz Balana, Brian Lord, Anindya Bhattacharya, Pascal Bonaventure, Jeffrey Schoellerman
Publikováno v:
The FASEB Journal. 34:1-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::453aee7d89ecac2e943c554aea0bee3b
https://doi.org/10.1096/fasebj.2020.34.s1.02275
https://doi.org/10.1096/fasebj.2020.34.s1.02275
Autor:
June Hyun Jung Kwon, Witek Kwiatkowski, Andrej Sali, Roland Riek, Bartosz Balana, Ellis Jeremy Chua Chiu, Navratna Vajpai, Senyon Choe, Luis Esquivies, Monika Bayrhuber, Innokentiy Maslennikov, Ursula Pieper, Katherine Y. Blain, Cédric Eichmann, Christian Klammt, Paul A. Slesinger
Publikováno v:
Nature Methods. 9:834-839
Although nearly half of today’s major pharmaceutical drugs target human integral membrane proteins (hIMPs), only 30 hIMP structures are currently available in the Protein Data Bank, largely owing to inefficiencies in protein production. Here we des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d1e472c8edd64024f2c0236193e73cd
https://doi.org/10.1038/nmeth.2033
https://doi.org/10.1038/nmeth.2033
Autor:
Ursula Ravens, Gouya Ram-Liebig, Gustavo B. Baretton, Michael Haase, Manfred P. Wirth, Bartosz Balana
Publikováno v:
World Journal of Urology. 24:429-437
Identification of biochemical and mechanical stimuli in order to modulate the function of bladder smooth muscle cells (SMC) in viable detrusor constructs. Human bladder detrusor cells were seeded on bladder acellular matrix and cultured under differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f1ba30de5b4746f1747bafe03c1d326
https://doi.org/10.1007/s00345-006-0104-0
https://doi.org/10.1007/s00345-006-0104-0
Autor:
Ursula Ravens, Jürgen F. Heubach, Ihor Zahanich, Torsten Christ, Sabine Boxberger, Erich Wettwer, Bartosz Balana, Manja Bock, Eva M. Graf, Judith Leutheuser
Publikováno v:
The Journal of Physiology. 554:659-672
Human mesenchymal stem cells (hMSC) have gained considerable interest due to their potential use for cell replacement therapy and tissue engineering. One strategy is to differentiate these bone marrow stem cells in vitro into cardiomyocytes prior to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::daf2c61a9599083d0be32c1a801247f0
https://doi.org/10.1113/jphysiol.2003.055806
https://doi.org/10.1113/jphysiol.2003.055806
Publikováno v:
Journal of Molecular and Cellular Cardiology. 35:1399-1405
Chronic atrial fibrillation (AF) is associated with shortening of action potential duration (APD), which involves modified activity of atrial ion currents. However, little is known about the activity of ATP-sensitive K(+) channels (I(K,ATP)) during c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5750aab805e16972a86614ba0985670
https://doi.org/10.1016/s0022-2828(03)00246-3
https://doi.org/10.1016/s0022-2828(03)00246-3