Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Barton Wicksteed"'
Autor:
Md. Wasim Khan, Alexander R. Terry, Medha Priyadarshini, Vladimir Ilievski, Zeenat Farooq, Grace Guzman, Jose Cordoba-Chacon, Issam Ben-Sahra, Barton Wicksteed, Brian T. Layden
Publikováno v:
Cell Death and Disease, Vol 13, Iss 7, Pp 1-17 (2022)
Mitochondrial interaction of HKDC1 is essential for its pro-proliferative role in LC. When HKDC1 is ablated in liver cancer cells, mitochondrial dysfunction occurs which results in decrease ATP in the cells. The cancer cells react to decreased cellul
Externí odkaz:
https://doaj.org/article/7091df137c6f4bf0aaa04fb1d39d604d
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Abstract Brown adipose tissue is a promising therapeutic target in metabolic disorders due to its ability to dissipate energy and improve systemic insulin sensitivity and glucose homeostasis. β-Adrenergic stimulation of brown adipocytes leads to an
Externí odkaz:
https://doaj.org/article/64ae880b3c6846a18c688151f4e5eae9
Autor:
Medha Priyadarshini, Kristen Lednovich, Kai Xu, Sophie Gough, Barton Wicksteed, Brian T. Layden
Publikováno v:
Metabolites, Vol 11, Iss 5, p 302 (2021)
The gut microbiome has emerged as a novel determinant of type 1 diabetes (T1D), but the underlying mechanisms are unknown. In this context, major gut microbial metabolites, short-chain fatty acids (SCFAs), are considered to be an important link betwe
Externí odkaz:
https://doaj.org/article/da67a29d55e843fca0a28b4a5d4a5983
Autor:
Sindhu Rajan, Lorna M. Dickson, Elizabeth Mathew, Caitlin M.O. Orr, Johanne H. Ellenbroek, Louis H. Philipson, Barton Wicksteed
Publikováno v:
Molecular Metabolism, Vol 4, Iss 4, Pp 265-276 (2015)
Objective: Glucagon-like peptide 1 (GLP-1) enhances insulin secretion and protects β-cell mass. Diabetes therapies targeting the GLP-1 receptor (GLP-1R), expressed in numerous tissues, have diminished dose-response in patients with type 2 diabetes c
Externí odkaz:
https://doaj.org/article/cca1781dfd7d4fb888d73a47bea9357d
Autor:
Miles Fuller, Xiaoran Li, Robert Fisch, Moneb Bughara, Barton Wicksteed, Petia Kovatcheva-Datchary, Brian T Layden
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0167837 (2016)
During the insulin resistant phase of pregnancy, the mRNA expression of free fatty acid 2 receptor (Ffar2) is upregulated and as we recently reported, this receptor contributes to insulin secretion and pancreatic beta cell mass expansion in order to
Externí odkaz:
https://doaj.org/article/95d8ecb6db144fe2a6584f5b706cafbe
Autor:
Kristen R. Lednovich, Chioma Nnyamah, Sophie Gough, Medha Priyadarshini, Kai Xu, Barton Wicksteed, Sidharth Mishra, Shalini Jain, Joseph L. Zapater, Hariom Yadav, Brian T. Layden
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 323(3)
Free fatty acid receptor 3 (FFA3) is a recently-deorphanized G-protein-coupled receptor. Its ligands are short-chain fatty acids (SCFAs), which are key nutrients derived from the gut microbiome fermentation process that play diverse roles in the regu
Publikováno v:
Endocrinology. 163
Hexokinase domain containing protein-1, or HKDC1, is a widely expressed hexokinase that is genetically associated with elevated 2-hour gestational blood glucose levels during an oral glucose tolerance test, suggesting a role for HKDC1 in postprandial
Publikováno v:
Journal of the Endocrine Society. 6:A25-A25
The obesity pandemic is a major health concern driving Type 2 Diabetes (T2D) and cardiovascular disease (CVD). One novel pathogenetic factor of obesity is the gut microbiome (GM), that is the microbes that reside in the digestive tract. Changes in th
Autor:
Sophie Gough, Brian Layden, Chioma Nnyamah, Medha Priyadarshini, Barton Wicksteed, Kristen Lednovich
Publikováno v:
Journal of the Endocrine Society. 6:A19-A19
Free fatty acid receptor 2 and free fatty acid receptor 3 (FFA2/3) are two highly similar G protein-coupled receptors belonging to the free fatty acid receptor family. Their ligands are short-chain fatty acids (SCFAs), which are key nutrients that pl
Publikováno v:
Journal of the Endocrine Society. 6:A419-A419
Hexokinase domain containing protein-1, or HKDC1, is a widely expressed novel hexokinase that is genetically associated with elevated 2-hour gestational blood glucose levels during an oral glucose tolerance test, suggesting a role for HKDC1 in postpr