Výsledky vyhledávání - "Barton R. Harris"

Corticosterone Increases Damage and Cytosolic Calcium Accumulation Associated With Ethanol Withdrawal in Rat Hippocampal Slice Cultures

Autor: Hilary J. Little, Patrick J. Mulholland, Mark A. Prendergast, John M. Littleton, Rachel L. Self, Barton R. Harris

Publikováno v: Alcoholism: Clinical & Experimental Research. 29:871-881

Background: Evidence suggests that stress hormones (i.e., glucocorticoids) may be increased during acute or chronic consumption of ethanol and during withdrawal from ethanol consumption, effects that may contribute to the development of cognitive imp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85d02571f239f27d21812d4555257de2
https://doi.org/10.1097/01.alc.0000163509.27577.da

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Corticosterone and dexamethasone potentiate cytotoxicity associated with oxygen-glucose deprivation in organotypic cerebellar slice cultures

Autor: Patrick J. Mulholland, T.D. Stepanyan, A. Kowalski, Rachel L. Self, Mark A. Prendergast, Barton R. Harris, Allison K. Hensley, John M. Littleton

Publikováno v: Neuroscience. 136:259-267

Many patients display elevated levels of serum cortisol following acute ischemic stroke. Given that glucocorticoids may potentiate some forms of insult, these studies examined the effects of corticosterone or dexamethasone exposure on cytotoxicity fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44771edf00bd85f761531bbb6669188b
https://doi.org/10.1016/j.neuroscience.2005.07.043

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Cytotoxic Effects of Exposure to the Human Immunodeficiency Virus Type 1 Protein Tat in the Hippocampus Are Enhanced by Prior Ethanol Treatment

Autor: Rachel L. Self, Avindra Nath, Patrick J. Mulholland, Mark A. Prendergast, Barton R. Harris

Publikováno v: Alcoholism: Clinical & Experimental Research. 28:1916-1924

BACKGROUND Long-term ethanol exposure leads to increases in the expression and/or sensitivity of NMDA-type glutamate receptors, effects that may contribute to the development of cytotoxicity in the brain. The human immunodeficiency virus 1 (HIV-1) tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6afbf557a1e529abef99223089155e32
https://doi.org/10.1097/01.alc.0000148108.93782.05

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The human immunodeficiency virus type-1 transcription factor Tat produces elevations in intracellular Ca2+ that require function of an N-methyl-d-aspartate receptor polyamine-sensitive site

Autor: Avindra Nath, Rachel L. Self, Barton R. Harris, Patrick J. Mulholland, Mark A. Prendergast

Publikováno v: Brain Research. 995:39-45

Human immunodeficiency virus type-1 (HIV-1) infection is commonly associated with neuronal loss, as well as, cognitive and motor deficits collectively termed HIV-1-associated dementia (HAD). Function of the HIV-1 transcription factor Tat, activation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8c9700d635b023b58c5d6046f912ae
https://doi.org/10.1016/j.brainres.2003.09.052

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The Neurotoxicity Induced by Ethanol Withdrawal in Mature Organotypic Hippocampal Slices Might Involve Cross-Talk Between Metabotropic Glutamate Type 5 Receptors and N-Methyl-d-Aspartate Receptors

Autor: Stewart R. Hart, Thomas C. Foster, Robert C. Holley, Rebecca L. Scotland, John A. Blanchard, Barton R. Harris, Norman W. Pedigo, John M. Littleton, D. Alex Gibson, Mark A. Prendergast

Publikováno v: Alcoholism: Clinical & Experimental Research. 27:1724-1735

Background: We recently reported that the sodium salt of acamprosate (Na-acamprosate) demonstrates the characteristics of an antagonist at metabotropic glutamate type 5 receptors (mGluR5s) rather than at N-methyl-d-aspartate receptors (NMDARs). Becau

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eafd0a70fd5b23b0a67a0a9b78292724
https://doi.org/10.1097/01.alc.0000093601.33119.e3

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Polyamines Contribute to Ethanol Withdrawal-Induced Neurotoxicity in Rat Hippocampal Slice Cultures Through Interactions With the NMDA Receptor

Autor: Barton R. Harris, Norman W. Pedigo, John M. Littleton, A I I John Blanchard, D. Alex Gibson, Mark A. Prendergast, Robert C. Holley, Stewart R. Hart

Publikováno v: Alcoholism: Clinical & Experimental Research. 27:1099-1106

BACKGROUND: Several reports demonstrate that withdrawal from long-term ethanol exposure is associated with significant central nervous system neurotoxicity, produced at least in part by increased activity of N-methyl-d-aspartate receptors (NMDARs). R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72881ce8b90e0a5accf68110b5530b98
https://doi.org/10.1097/01.alc.0000075824.10502.dd

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Radioligand binding studies reveal agmatine is a more selective antagonist for a polyamine-site on the NMDA receptor than arcaine or ifenprodil

Autor: D. Alex Gibson, Barton R. Harris, John M. Littleton, D. Trent Rogers

Publikováno v: Brain Research. 952:71-77

Ifenprodil, arcaine and agmatine have all been reported to inhibit the NMDA receptor by actions at polyamine-sites, however the specific sites with which these compounds interact is unknown. Here we used radioligand binding of [3H]MK-801 to a membran

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50a99055bb5617294b1c25f94e7abe40
https://doi.org/10.1016/s0006-8993(02)03198-0

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Acamprosate Has No Effect on NMDA-Induced Toxicity But Reduces Toxicity Induced by Spermidine or by Changing the Medium in Organotypic Hippocampal Slice Cultures From Rat

Autor: Sveta Mayer, Robert C. Holley, John A. Blanchard, D. Alex Gibson, Mark A. Prendergast, John M. Littleton, Barton R. Harris

Publikováno v: Alcoholism: Clinical and Experimental Research. 26:655-662

BACKGROUND: It has been suggested that the antirelapse drug acamprosate can inhibit or potentiate glutamate/NMDA receptor-mediated responses via a polyamine site. Additionally, subchronic exposure to acamprosate increases expression of some NMDA rece

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::45312183ce3f1dcd9870f02df5141464
https://doi.org/10.1111/j.1530-0277.2002.tb02587.x

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Chronic nicotine exposure reduces N-methyl-d-aspartate receptor-mediated damage in the hippocampus without altering calcium accumulation or extrusion: evidence of calbindin-D28K overexpression

Autor: Barton R. Harris, Sveta Mayer, Robert C. Holley, Kurt F. Hauser, John M. Littleton, Mark A. Prendergast

Publikováno v: Neuroscience. 102:75-85

Neuronal accumulation of excess Ca2+ has been implicated in cellular death following several forms of physical and chemotoxic insult. Recent studies have suggested that exposure to agonists at brain nicotinic acetylcholine receptors reduces cytotoxic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa5b4493203aac0eb2d1ce279fc5da03
https://doi.org/10.1016/s0306-4522(00)00450-4

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