Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Barton H. Manning"'
Autor:
Eileen Johnson, Jerry Ryan Holder, Barton H. Manning, Licheng Shi, Kevin Salyers, Michael Stenkilsson, Colin V. Gegg, Marie E. Wright, George Doellgast, Kenneth D. Wild, Les P. Miranda
Publikováno v:
Biopolymers. 100:422-430
Antagonism of the calcitonin gene-related peptide (CGRP) receptor may be a useful approach for migraine treatment. Selective PEGylated peptide antagonists to the CGRP receptor are described, derived from CGRP(8-37) with polymer derivatization at an e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ea37007135bf79af7cc0c5558bc94bf
https://doi.org/10.1002/bip.22270
https://doi.org/10.1002/bip.22270
Autor:
Randall W. Hungate, Ming Huang, Gloria Biddlecome, Jason Brooks Human, Benny C. Askew, Jian J. Chen, Dianna Lester-Zeiner, Eileen Johnson, Wenyuan Qian, Barton H. Manning, Leyla Arik, Richard Loeloff, Toshihiro Aya, Kaustav Biswas, Hong Dong, Tanya Peterkin, Hong Sun, Gondi N. Kumar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:4764-4769
We report the development of aryl sulfones as Bradykinin B1 receptor antagonists. Variation of the linker region identified diol 23 as a potent B1 antagonist, while modifications of the aryl moiety led to compound 26, both of which were efficacious i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c203023ad80d700642c9509253c1f5f
https://doi.org/10.1016/j.bmcl.2008.07.108
https://doi.org/10.1016/j.bmcl.2008.07.108
Autor:
Mark H. Norman, Lana Klionsky, Maosheng Zhang, Jue Wang, Ella Magal, Sekhar Surapaneni, Rami Tamir, Judy Wang, John Rubino, Hong Deng, Jean-Claude Louis, Dawn Zhu, Doo Lee, Barton H. Manning, Tingrong Wang, Weiya Wang, April Le, Nuria A. Tamayo, Rongzhen Kuang, Narender R. Gavva, Sonya G. Lehto, Brad Youngblood
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 326:218-229
Antagonists of the vanilloid receptor TRPV1 (transient receptor potential vanilloid type 1) have been reported to produce antihyperalgesic effects in animal models of pain. These antagonists, however, also caused concomitant hyperthermia in rodents,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d5eb44da8ff03c509995370a92b65408
https://doi.org/10.1124/jpet.107.132233
https://doi.org/10.1124/jpet.107.132233
Autor:
Xiao Ding, Jian J. Chen, Eileen Johnson, Hong Dong, Hong Sun, Gondi N. Kumar, Barton H. Manning, Ella Magal
Publikováno v:
Journal of Neuroscience Methods. 168:76-87
The discovery of novel analgesic compounds that target some receptors can be challenging due to species differences in ligand pharmacology. If a putative analgesic compound has markedly lower affinity for rodent versus other mammalian orthologs of a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1759d6693ac4a8d8a5a616b1b6b0abaa
https://doi.org/10.1016/j.jneumeth.2007.09.028
https://doi.org/10.1016/j.jneumeth.2007.09.028
Autor:
Burgess Laurence E, Leyla Arik, Chester Chenguang Yuan, Nianhe Han, Randall W. Hungate, Derin C. D'amico, David A. Mareska, Feng-Yin Hsieh, Eileen Johnson, Hong Sun, Qingyian Liu, Barton H. Manning, Bobby Riahi, Christopher H. Fotsch, Gloria Biddlecome, Mark H. Norman, Augustus Kamassah, Ming Huang, Richard Loeloff, Gondi N. Kumar, Andras Toro, Jian J. Chen, Jason Brooks Human, Hideo Suzuki, Robert D. Groneberg, Benny C. Askew, Aiwen Li, Gordon Ng, James Zhan, Kaustav Biswas, Dianna Lester-Zeiner, Hong Dong, David E. Clarke
Publikováno v:
Journal of Medicinal Chemistry. 50:2200-2212
The bradykinin B1 receptor is induced following tissue injury and/or inflammation. Antagonists of this receptor have been studied as promising candidates for treatment of chronic pain. We have identified aryl sulfonamides containing a chiral chroman
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb42b5aad05a1dc5bda8d29f83bc6dc6
https://doi.org/10.1021/jm070055c
https://doi.org/10.1021/jm070055c
Publikováno v:
Proceedings of the National Academy of Sciences. 98:8077-8082
Numerous human and animal studies indirectly implicate neurons in the anterior cingulate cortex (ACC) in the encoding of the affective consequences of nociceptor stimulation. No causal evidence, however, has been put forth linking the ACC specificall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792bb12eb2a632fe1ae71ab05f86e2fd
https://doi.org/10.1073/pnas.141218998
https://doi.org/10.1073/pnas.141218998
Autor:
Les P, Miranda, Licheng, Shi, Jerry R, Holder, Marie, Wright, Colin V, Gegg, Eileen, Johnson, Kenneth, Wild, Michael, Stenkilsson, George, Doellgast, Barton H, Manning, Kevin, Salyers
Publikováno v:
Biopolymers. 100(4)
Antagonism of the calcitonin gene-related peptide (CGRP) receptor may be a useful approach for migraine treatment. Selective PEGylated peptide antagonists to the CGRP receptor are described, derived from CGRP(8-37) with polymer derivatization at an e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a31b70dedf454786a35ff7d2eadd6074
https://pubmed.ncbi.nlm.nih.gov/23868210
https://pubmed.ncbi.nlm.nih.gov/23868210
Publikováno v:
Pain. 67:79-88
N-Methyl-D-aspartate (NMDA) receptor antagonists have been repeatedly shown to attenuate the development of opiate tolerance and dependence in rodents. In the present experiments, continuous subcutaneous infusion of either MK-801 (0.01 mg/kg/h but no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d4745010ddf00993bc91bb7021e33f
https://doi.org/10.1016/0304-3959(96)81972-5
https://doi.org/10.1016/0304-3959(96)81972-5
Autor:
Sonya G, Lehto, Rami, Tamir, Hong, Deng, Lana, Klionsky, Rongzhen, Kuang, April, Le, Doo, Lee, Jean-Claude, Louis, Ella, Magal, Barton H, Manning, John, Rubino, Sekhar, Surapaneni, Nuria, Tamayo, Tingrong, Wang, Judy, Wang, Jue, Wang, Weiya, Wang, Brad, Youngblood, Maosheng, Zhang, Dawn, Zhu, Mark H, Norman, Narender R, Gavva
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 326(1)
Antagonists of the vanilloid receptor TRPV1 (transient receptor potential vanilloid type 1) have been reported to produce antihyperalgesic effects in animal models of pain. These antagonists, however, also caused concomitant hyperthermia in rodents,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::23003f75c2737d279805308b147d8874
https://pubmed.ncbi.nlm.nih.gov/18420600
https://pubmed.ncbi.nlm.nih.gov/18420600
