Zobrazeno 1 - 10
of 166
pro vyhledávání: '"Barton A. Kamen"'
Autor:
Eati Basal, Guiti Z Eghbali-Fatourechi, Kimberly R Kalli, Lynn C Hartmann, Karin M Goodman, Ellen L Goode, Barton A Kamen, Philip S Low, Keith L Knutson
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6292 (2009)
BACKGROUND:Despite low incidence, ovarian cancer is the fifth leading cause of cancer deaths and it has the highest mortality rate of all gynecologic malignancies among US women. The mortality rate would be reduced with an early detection marker. The
Externí odkaz:
https://doaj.org/article/482f84811a6445648d675706197da24d
Autor:
Ruth Croxford, S. E. Kim, Peter D. Cole, Robert C. Cho, Anna Ly, L. Ishiguro, Kyoung-Jin Sohn, Young-In Kim, Barton A. Kamen
Publikováno v:
British Journal of Cancer
Background: γ-Glutamyl hydrolase (GGH) regulates intracellular folate and antifolates for optimal nucleotide biosynthesis and antifolate-induced cytotoxicity, respectively. The modulation of GGH may therefore affect chemosensitivity of cancer cells,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59a294a35b4ecacec903aa23377b8d5e
http://europepmc.org/articles/PMC3798974
http://europepmc.org/articles/PMC3798974
Autor:
Angela K. Smith, Barton A. Kamen
Publikováno v:
Cancer Chemotherapy and Pharmacology. 70:113-120
Folate is a cofactor in the synthesis of purines and pyrimidines; folate analogs are potent cytotoxic drugs. Folate receptor alpha (FRα), a protein-mediating cellular accumulation of folate (and anti-folates), has limited expression in normal tissue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd2017bf79ba2904c478d13fbe706069
https://doi.org/10.1007/s00280-012-1890-2
https://doi.org/10.1007/s00280-012-1890-2
Autor:
Laurent Brard, Shannon R. Lenox, Peter M. Bingham, Taka Ashikaga, Ajay P. Singh, Alan Homans, Giselle Saulnier Sholler, Barton A. Kamen, Barry W. Heath, Marni A Slavik, Genevieve Bergendahl, Timothy Higgins, William S. Ferguson
Publikováno v:
Journal of Pediatric Hematology/Oncology. 33:25-30
The primary aim of this phase 1 study was to determine the maximum tolerated dose (MTD) and evaluate the safety of nifurtimox alone and in combination with cyclophosphamide and topotecan in multiple relapsed/refractory neuroblastoma pediatric patient
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01fd4d5ca80cef94b07a52cf7fb1dbc
https://doi.org/10.1097/mph.0b013e3181f47061
https://doi.org/10.1097/mph.0b013e3181f47061
Autor:
Richard H. Finnell, Joanne R. Lupton, Nysia I. George, Laurie A. Davidson, Barton A. Kamen, Evelyn S. Callaway, Robert S. Chapkin, Naisyin Wang
Publikováno v:
The Journal of Nutritional Biochemistry. 20:649-655
Inflammatory bowel disease (IBD) patients are at high risk for developing folate deficiency and colon cancer. Since it is difficult to study the subtle global and gene-specific epigenetic mechanisms involved in folate-mediated tumor initiation and pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed41f3d95b216599e315af1fb5bfdc37
https://doi.org/10.1016/j.jnutbio.2008.07.001
https://doi.org/10.1016/j.jnutbio.2008.07.001
Autor:
Peter D. Cole, Barton A. Kamen, Angela K. Smith, Sudipta Roychowdhury, Veena Vijayanathan, Katherine A. Beckwith
Publikováno v:
Pediatric Neurology. 40:34-41
The neurotoxic effects of therapy for childhood acute lymphoblastic leukemia can result in leukoencephalopathy or measurable deficits in cognitive function. However, there are no validated biomarkers that allow the identification of those patients at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d66c40d7978a3e7303946e1bc29108eb
https://doi.org/10.1016/j.pediatrneurol.2008.09.005
https://doi.org/10.1016/j.pediatrneurol.2008.09.005
Publikováno v:
Clinical Genetics. 45:212-216
A 13-year-old male presented with new onset seizures, sagittal sinus thrombosis with cerebral hemorrhage, and extensive venous thrombosis of the lower limbs. Laboratory investigation demonstrated combined deficiency of protein C, protein S, and antit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7985293f4328b871336d5eb714a68a
https://doi.org/10.1111/j.1399-0004.1994.tb04026.x
https://doi.org/10.1111/j.1399-0004.1994.tb04026.x
Autor:
Peter D. Cole, I. David Goldman, Andong Qiu, John Glod, Barton A. Kamen, Stuti Ahlawat, Angela K. Smith, Benedette Makori, Rajeth Koneru, Jan B. Wollack, Sonia C. Picinich
Publikováno v:
Journal of Neurochemistry. 104:1494-1503
Reduced derivatives of folic acid (folates) play a critical role in the development, function and repair of the CNS. However, the molecular systems regulating folate uptake and homeostasis in the central nervous system remain incompletely defined. Ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fdce930798e4b9055ade925d0f0dee8c
https://doi.org/10.1111/j.1471-4159.2007.05095.x
https://doi.org/10.1111/j.1471-4159.2007.05095.x
Publikováno v:
Cancer Chemotherapy and Pharmacology. 60:883-889
The DNA repair protein, O (6)-alkylguanine-DNA alkyltransferase (AGT), is a primary source of tumor resistance to agents such as temozolomide and chloroethylnitrosoureas that form DNA lesions at the O (6)-position of guanines. To increase the efficac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e4367c59338d09d005903ec4a037215
https://doi.org/10.1007/s00280-007-0435-6
https://doi.org/10.1007/s00280-007-0435-6
Autor:
Barton A. Kamen, Peter D. Cole
Publikováno v:
Mental Retardation and Developmental Disabilities Research Reviews. 12:174-183
Most children diagnosed today with acute lymphoblastic leukemia (ALL) will be cured. However, treatment entails risk of neurotoxicity, causing deficits in neurocognitive function that can persist in the years after treatment is completed. Many of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3763dec654dfd296f1fe3dd89f4cad08
https://doi.org/10.1002/mrdd.20113
https://doi.org/10.1002/mrdd.20113