A selective p53 activator and anticancer agent to improve colorectal cancer therapy

Autor: Helena Ramos, Maria I.L. Soares, Joana Silva, Liliana Raimundo, Juliana Calheiros, Célia Gomes, Flávio Reis, Filipe A. Monteiro, Cláudia Nunes, Salette Reis, Bartolomeo Bosco, Silvano Piazza, Lucília Domingues, Petr Chlapek, Petr Vlcek, Pavel Fabian, Ana Teresa Rajado, A.T.P. Carvalho, Renata Veselska, Alberto Inga, Teresa M.V.D. Pinho e Melo, Lucília Saraiva

Publikováno v: Cell Reports, Vol 35, Iss 2, Pp 108982- (2021)

Summary: Impairment of the p53 pathway is a critical event in cancer. Therefore, reestablishing p53 activity has become one of the most appealing anticancer therapeutic strategies. Here, we disclose the p53-activating anticancer drug (3S)-6,7-bis(hyd

Externí odkaz: https://doaj.org/article/49516e7fa22e429b9dc9fbabff3cfc73

DHX30 Coordinates Cytoplasmic Translation and Mitochondrial Function Contributing to Cancer Cell Survival

Autor: Dario Rizzotto, Alicia Perzolli, Bartolomeo Bosco, Alessandra Bisio, Meriem Hadjer Hamadou, Frédéric Catez, Erik Dassi, Angeline Gaucherot, Jean-Jacques Diaz, Sebastiano Giorgetta, Alberto Inga, Annalisa Rossi, Francesco Bonollo

Publikováno v: Cancers
Volume 13
Issue 17
Cancers, MDPI, 2021, 13, ⟨10.3390/cancers13174412⟩
Cancers, Vol 13, Iss 4412, p 4412 (2021)

Simple Summary Translation occurs in the cell both through cytoplasmic and mitochondrial ribosomes, respectively translating mRNAs encoded by the nuclear and the mitochondrial genome. Here we found that the silencing of DHX30, an RNA-binding protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::856ce57671611e3ad03ab0782458ca6e

DHX30 coordinates cytoplasmic translation and mitochondrial function contributing to cancer cell survival

Autor: Dario Rizzotto, Alicia Perzolli, Erik Dassi, Angeline Gaucherot, Frédéric Catez, Sebastiano Giorgetta, Jean-Jacques Diaz, Bartolomeo Bosco, Alberto Inga, Annalisa Rossi, Francesco Bonollo

DHX30 was recently implicated in the translation control of mRNAs involved in p53-dependent apoptosis. Here we show that DHX30 exhibits a more general function by integrating the activities of its cytoplasmic isoform and of the more abundant mitochon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbbfe48cd78594e8443bef2a812f2916
https://doi.org/10.1101/2020.07.13.196709

SLMP53-2 Restores Wild-Type-Like Function to Mutant p53 through Hsp70: Promising Activity in Hepatocellular Carcinoma

Autor: Alessandra Bisio, Bartolomeo Bosco, Helena Ramos, Flávio Reis, Carla Cristina Marques de Oliveira, Alberto Inga, Maria Inês Almeida, Célia Gomes, Silvano Piazza, Maria M. M. Santos, Lucília Domingues, Lucília Saraiva, Liliana Raimundo, Matthias R. Bauer, Alan R. Fersht, Sara Gomes, Joana Soares, Nair Nazareth, Joao Paulo Bras, Joana B. Loureiro, Valentina Barcherini

Publikováno v: Cancers, Vol 11, Iss 8, p 1151 (2019)
Cancers
Cancers; Volume 11; Issue 8; Pages: 1151
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

Half of human cancers harbor TP53 mutations that render p53 inactive as a tumor suppressor. In these cancers, reactivation of mutant p53 (mutp53) through restoration of wild-type-like function constitutes a valuable anticancer therapeutic strategy. I

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f626b299d559bf9758b3526b8e51f452
https://www.mdpi.com/2072-6694/11/8/1151

Synthesis of 2,6-Diamino-Substituted Purine Derivatives and Evaluation of Cell Cycle Arrest in Breast and Colorectal Cancer Cells

Autor: Yari Ciribilli, Tania Incitti, Angela Bozza, Andrea Messina, Bartolomeo Bosco, Denise Sighel, Alberto Inga, Andrea Defant, Ines Mancini, Simona Casarosa

Publikováno v: Molecules
Volume 23
Issue 8
Molecules : A Journal of Synthetic Chemistry and Natural Product Chemistry
Molecules, Vol 23, Iss 8, p 1996 (2018)

Reversine is a potent antitumor 2,6-diamino-substituted purine acting as an Aurora kinases inhibitor and interfering with cancer cell cycle progression. In this study we describe three reversine-related molecules, designed by docking calculation, tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf5103f2ed8ce471cac54075361edc5
https://doi.org/10.3390/molecules23081996