Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Bartolome Moya"'
Autor:
Silvia López-Argüello, Maria Montaner, Amanda Mármol-Salvador, Ana Velázquez-Escudero, Fernando Docobo-Pérez, Antonio Oliver, Bartolome Moya
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT The lack of effective first-line antibiotic treatments against Neisseria gonorrhoeae, and the worldwide dissemination of resistant strains, are the main drivers of a worsening global health crisis. β-lactam antibiotics have been the backbon
Externí odkaz:
https://doaj.org/article/e492cafbdf964dcc85650c281de9f95e
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 1 (2023)
ABSTRACT The lack of effective treatment options against Pseudomonas aeruginosa is one of the main contributors to the silent pandemic. Many antibiotics are ineffective against resistant isolates due to poor target site penetration, efflux, or β-lac
Externí odkaz:
https://doaj.org/article/ad1a5e3178a24afab082a0a7bfa76808
Autor:
Tae Hwan Kim, Xun Tao, Bartolome Moya, Yuanyuan Jiao, Kari B. Basso, Jieqiang Zhou, Yinzhi Lang, Dhruvitkumar S. Sutaria, Alexandre P. Zavascki, Afonso L. Barth, Stephanie M. Reeve, Herbert P. Schweizer, Deanna Deveson Lucas, John D. Boyce, Robert A. Bonomo, Richard E. Lee, Beom Soo Shin, Arnold Louie, George L. Drusano, Jürgen B. Bulitta
Publikováno v:
mBio, Vol 11, Iss 1 (2020)
ABSTRACT Poor penetration through the outer membrane (OM) of Gram-negative bacteria is a major barrier of antibiotic development. While β-lactam antibiotics are commonly used against Klebsiella pneumoniae and Enterobacter cloacae, there are limited
Externí odkaz:
https://doaj.org/article/15920c889cbe439dba2992e6e5cf4623
Autor:
Gabriel Torrens, Sara Belén Hernández, Juan Alfonso Ayala, Bartolome Moya, Carlos Juan, Felipe Cava, Antonio Oliver
Publikováno v:
mSystems, Vol 4, Iss 6 (2019)
ABSTRACT The hyperproduction of the chromosomal AmpC β-lactamase is the main mechanism driving β-lactam resistance in Pseudomonas aeruginosa, one of the leading opportunistic pathogens causing nosocomial acute and chronic infections in patients wit
Externí odkaz:
https://doaj.org/article/db8ec4c9be0a4961842706556389aa01
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 6, p 3051 (2021)
Avibactam belongs to the new class of diazabicyclooctane β-lactamase inhibitors. Its inhibitory spectrum includes class A, C and D enzymes, including P. aeruginosa AmpC. Nonetheless, recent reports have revealed strain-dependent avibactam AmpC induc
Externí odkaz:
https://doaj.org/article/2923f8a298244df59be8c97f201e7b85
Autor:
Silvia López-Argüello, Maria Montaner, Alaa RM. Sayed, Antonio Oliver, Jürgen B. Bulitta, Bartolome Moya
Publikováno v:
Antimicrobial Agents and Chemotherapy.
The β-lactam antibiotics have been successfully used for decades to combat susceptible Pseudomonas aeruginosa , which has a notoriously difficult to penetrate outer membrane (OM). However, there is a dearth of data on target site penetration and cov
Publikováno v:
Microbiology spectrum.
The lack of effective treatment options against Pseudomonas aeruginosa is one of the main contributors to the silent pandemic. Many antibiotics are ineffective against resistant isolates due to poor target site penetration, efflux, or β-lactamase hy
Autor:
Dhruvitkumar S. Sutaria, Beom Soo Shin, Kari B. Basso, Herbert P. Schweizer, Stephanie M. Reeve, Richard E. Lee, Xun Tao, Bartolome Moya, John D. Boyce, Robert A. Bonomo, Deanna Deveson Lucas, Yinzhi Lang, Afonso Luis Barth, George L. Drusano, Yuanyuan Jiao, Jieqiang Zhou, Alexandre P. Zavascki, Jürgen B. Bulitta, Arnold Louie, Tae Hwan Kim
Publikováno v:
mBio, Vol 11, Iss 1, p e03189-19 (2020)
mBio, Vol 11, Iss 1 (2020)
mBio, Vol 11, Iss 1 (2020)
Poor penetration through the outer membrane (OM) of Gram-negative bacteria is a major barrier of antibiotic development. While β-lactam antibiotics are commonly used against Klebsiella pneumoniae and Enterobacter cloacae, there are limited data on O
Autor:
Yuanyuan Jiao, Bartolome Moya, Jürgen B. Bulitta, Cornelia B. Landersdorfer, Martina Kinzig, Dhruvitkumar S. Sutaria, Tae Hwan Kim, Ulrike Holzgrabe, Fritz Sörgel, Xun Tao, Stefanie K. Drescher
Publikováno v:
European Journal of Pharmaceutical Sciences. 123:416-428
Understanding the pharmacokinetics in patients with cystic fibrosis (CF) is important for dosing. For antibiotics with extensive metabolism, however, a comparison of metabolite formation and elimination between patients with CF and healthy volunteers
Autor:
Bartolome Moya, Sara B. Hernández, Antonio Oliver, Juan A. Ayala, Carlos Juan, Gabriel Torrens, Felipe Cava
Publikováno v:
mSystems
mSystems, Vol 4, Iss 6, p e00524-19 (2019)
mSystems, Vol 4, Iss 6 (2019)
mSystems, Vol 4, Iss 6, p e00524-19 (2019)
mSystems, Vol 4, Iss 6 (2019)
The hyperproduction of the chromosomal AmpC beta-lactamase is the main mechanism driving beta-lactam resistance in Pseudomonas aeruginosa, one of the leading opportunistic pathogens causing nosocomial acute and chronic infections in patients with und