Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Bartlomiej Bartkowiak"'
Autor:
Brian Magnuson, Karan Bedi, Ishwarya Venkata Narayanan, Bartlomiej Bartkowiak, Hailey Blinkiewicz, Michelle T. Paulsen, Arno Greenleaf, Mats Ljungman
Publikováno v:
iScience, Vol 25, Iss 9, Pp 105030- (2022)
Summary: The cyclin-dependent kinase CDK12 has garnered interest as a cancer therapeutic target as DNA damage response genes are particularly suppressed by loss of CDK12 activity. In this study, we assessed the acute effects of CDK12 inhibition on tr
Externí odkaz:
https://doaj.org/article/b01a9fc8f75748d3a89e13357606dce7
Publikováno v:
Biomolecules, Vol 9, Iss 10, p 634 (2019)
We asked whether the C-terminal repeat domain (CTD) kinase, CDK12/CyclinK, phosphorylates substrates in addition to the CTD of RPB1, using our CDK12analog-sensitive HeLa cell line to investigate CDK12 activity-dependent phosphorylation events in huma
Externí odkaz:
https://doaj.org/article/4a2a99b3d3f54660a4a959687788d89f
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e60909 (2013)
RNA polymerase II translocates across much of the genome and since it can be blocked by many kinds of DNA lesions, detects DNA damage proficiently; it thereby contributes to DNA repair and to normal levels of DNA damage resistance. However, the compo
Externí odkaz:
https://doaj.org/article/842d140183d0487fa03126abb5f4214f
Publikováno v:
First Aid Perioperative Ultrasound ISBN: 9783031212901
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7c5726be6926764933b971afba151f7
https://doi.org/10.1007/978-3-031-21291-8_35
https://doi.org/10.1007/978-3-031-21291-8_35
Autor:
Bartlomiej Bartkowiak, Matthew M. Churpek, Kevin K. Roggin, Ashley Snyder, Andrew B. Schneider, Andrew J. Benjamin, Nicole M. Twu, Dana P. Edelson
Publikováno v:
Ann Surg
OBJECTIVE: Assess the accuracy of three early warning scores for predicting severe adverse events in postoperative inpatients. SUMMARY BACKGROUND DATA: Postoperative clinical deterioration on inpatient hospital services is associated with increased m
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1849:1179-1187
The RNA Polymerase II C-terminal domain (CTD) kinase CDK12 has been implicated as a tumor suppressor and regulator of DNA damage response genes. Although much has been learned about CDK12 and its activity, due to the lack of a specific inhibitor and
Publikováno v:
The Journal of Biological Chemistry
Background: CDK12 helps to regulate DNA transcription and associated processes. Results: Full-length and active CDK12 can be expressed using baculovirus and CDK12 interacts with many RNA processing factors. Conclusion: CDK12 may affect RNA processing
Autor:
Olufunmilayo I. Olopade, Vineet M. Arora, Daniel W. Golden, Ryan P. McKillip, Carol A. Rosenberg, Olwen Hahn, Bartlomiej Bartkowiak
Publikováno v:
Journal of cancer education : the official journal of the American Association for Cancer Education. 34(1)
As the population of patients with cancer and survivors grows, physician knowledge of oncology clinical care and research is increasingly important. Despite this patient population growth, medical students and non-oncology physicians report insuffici
Publikováno v:
Biomolecules
Volume 9
Issue 10
Biomolecules, Vol 9, Iss 10, p 634 (2019)
Volume 9
Issue 10
Biomolecules, Vol 9, Iss 10, p 634 (2019)
We asked whether the C-terminal repeat domain (CTD) kinase, CDK12/CyclinK, phosphorylates substrates in addition to the CTD of RPB1, using our CDK12analog-sensitive HeLa cell line to investigate CDK12 activity-dependent phosphorylation events in huma
Autor:
Bartlomiej Bartkowiak, Hemali Phatnani, David H. Price, Nicholas J. Fuda, Arno L. Greenleaf, John T. Lis, Pengda Liu, Karen Adelman, Jeffrey J. Cooper
Publikováno v:
Genes & Development. 24:2303-2316
The C-terminal repeat domain (CTD) of RNA polymerase II (RNAPII) is an intrinsically unstructured extension of the enzyme's largest subunit, RPB1. The CTD is composed of a tandem array of seven amino acid repeats with the consensus sequence Y1S2P3T4S