Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Bartley W. Halstead"'
Autor:
Robert M. Campbell, Sean G. Buchanan, James R. Henry, David A. Barda, Gregory D. Plowman, Christoph Reinhard, Bharvin K.R. Patel, Xiang S. Ye, Maria Jose Lallena, Emiko L. Kreklau, Shripad V. Bhagwat, Ricardo Martinez, Matthew Z. Dieter, Bartley W. Halstead, Jennie L. Walgren, Jason R. Manro, Phillip W. Iversen, Michele S. Dowless, Louis F. Stancato, Shobha Bhattachar, Shaoyou Chu, Amit Aggarwal, Yue W. Webster, Yuewei Qian, Li-Chun Chio, Mark S. Marshall, Richard P. Beckmann, Jack A. Dempsey, Darlene S. Barnard, Robert D. Van Horn, Gregory P. Donoho, Andrew Capen, Robert T. Foreman, Sarah M. Bogner, Yi Zeng, Yanzhu Yang, Sonya C. Chapman, Yu-Hua Hui, Carmen Baquero, Karsten Boehnke, Carlos Marugán, Huimin Bian, Xueqian Gong, Raquel Torres, Lei Yan, Jian Du
Supplementary Materials and Methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04ab9e588f7270d239b69faebcc24e90
https://doi.org/10.1158/1535-7163.22506969.v1
https://doi.org/10.1158/1535-7163.22506969.v1
Autor:
Robert M. Campbell, Sean G. Buchanan, James R. Henry, David A. Barda, Gregory D. Plowman, Christoph Reinhard, Bharvin K.R. Patel, Xiang S. Ye, Maria Jose Lallena, Emiko L. Kreklau, Shripad V. Bhagwat, Ricardo Martinez, Matthew Z. Dieter, Bartley W. Halstead, Jennie L. Walgren, Jason R. Manro, Phillip W. Iversen, Michele S. Dowless, Louis F. Stancato, Shobha Bhattachar, Shaoyou Chu, Amit Aggarwal, Yue W. Webster, Yuewei Qian, Li-Chun Chio, Mark S. Marshall, Richard P. Beckmann, Jack A. Dempsey, Darlene S. Barnard, Robert D. Van Horn, Gregory P. Donoho, Andrew Capen, Robert T. Foreman, Sarah M. Bogner, Yi Zeng, Yanzhu Yang, Sonya C. Chapman, Yu-Hua Hui, Carmen Baquero, Karsten Boehnke, Carlos Marugán, Huimin Bian, Xueqian Gong, Raquel Torres, Lei Yan, Jian Du
Although Aurora A, B, and C kinases share high sequence similarity, especially within the kinase domain, they function distinctly in cell-cycle progression. Aurora A depletion primarily leads to mitotic spindle formation defects and consequently prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0aca539a9e32036f4566410352eeff32
https://doi.org/10.1158/1535-7163.c.6538536.v1
https://doi.org/10.1158/1535-7163.c.6538536.v1
Autor:
Robert M. Campbell, Sean G. Buchanan, James R. Henry, David A. Barda, Gregory D. Plowman, Christoph Reinhard, Bharvin K.R. Patel, Xiang S. Ye, Maria Jose Lallena, Emiko L. Kreklau, Shripad V. Bhagwat, Ricardo Martinez, Matthew Z. Dieter, Bartley W. Halstead, Jennie L. Walgren, Jason R. Manro, Phillip W. Iversen, Michele S. Dowless, Louis F. Stancato, Shobha Bhattachar, Shaoyou Chu, Amit Aggarwal, Yue W. Webster, Yuewei Qian, Li-Chun Chio, Mark S. Marshall, Richard P. Beckmann, Jack A. Dempsey, Darlene S. Barnard, Robert D. Van Horn, Gregory P. Donoho, Andrew Capen, Robert T. Foreman, Sarah M. Bogner, Yi Zeng, Yanzhu Yang, Sonya C. Chapman, Yu-Hua Hui, Carmen Baquero, Karsten Boehnke, Carlos Marugán, Huimin Bian, Xueqian Gong, Raquel Torres, Lei Yan, Jian Du
Supplementary Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b687d979fb87e1752e656129b11b4a8
https://doi.org/10.1158/1535-7163.22506966
https://doi.org/10.1158/1535-7163.22506966
Autor:
Robert M. Campbell, Sean G. Buchanan, James R. Henry, David A. Barda, Gregory D. Plowman, Christoph Reinhard, Bharvin K.R. Patel, Xiang S. Ye, Maria Jose Lallena, Emiko L. Kreklau, Shripad V. Bhagwat, Ricardo Martinez, Matthew Z. Dieter, Bartley W. Halstead, Jennie L. Walgren, Jason R. Manro, Phillip W. Iversen, Michele S. Dowless, Louis F. Stancato, Shobha Bhattachar, Shaoyou Chu, Amit Aggarwal, Yue W. Webster, Yuewei Qian, Li-Chun Chio, Mark S. Marshall, Richard P. Beckmann, Jack A. Dempsey, Darlene S. Barnard, Robert D. Van Horn, Gregory P. Donoho, Andrew Capen, Robert T. Foreman, Sarah M. Bogner, Yi Zeng, Yanzhu Yang, Sonya C. Chapman, Yu-Hua Hui, Carmen Baquero, Karsten Boehnke, Carlos Marugán, Huimin Bian, Xueqian Gong, Raquel Torres, Lei Yan, Jian Du
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9753ae2ef1911fad6be7d03eb93839c9
https://doi.org/10.1158/1535-7163.22506972.v1
https://doi.org/10.1158/1535-7163.22506972.v1
Autor:
Xueqian Gong, Karsten Boehnke, Carmen Baquero, Yue-Wei Qian, Gregory P. Donoho, Jason Manro, Robert T. Foreman, Carlos Marugán, Sonya C. Chapman, Yi Zeng, Phillip W Iversen, Jack A. Dempsey, Matthew Z. Dieter, David Anthony Barda, Henry James Robert, Michele Dowless, Shripad V. Bhagwat, Robert M. Campbell, Andrew Capen, Robert D. Van Horn, Amit Aggarwal, Mark S. Marshall, Darlene S. Barnard, Bharvin K. R. Patel, Louis Stancato, Huimin Bian, Li-Chun Chio, Sean Buchanan, Jian Du, Richard P. Beckmann, Christoph Reinhard, Ricardo Martinez, Gregory D. Plowman, Lei Yan, Shobha N. Bhattachar, Sarah M. Bogner, Maria Jose Lallena, Xiang S. Ye, Jennie L. Walgren, Yu-Hua Hui, Yue Webster, Emiko L. Kreklau, Raquel Torres, Yanzhu Yang, Bartley W. Halstead, Shaoyou Chu
Publikováno v:
Molecular Cancer Therapeutics. 18:2207-2219
Although Aurora A, B, and C kinases share high sequence similarity, especially within the kinase domain, they function distinctly in cell-cycle progression. Aurora A depletion primarily leads to mitotic spindle formation defects and consequently prom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea271aab24607f19770d2cdca75d5d3
https://doi.org/10.1158/1535-7163.mct-18-0529
https://doi.org/10.1158/1535-7163.mct-18-0529
Autor:
Jeffrey A. Willy, Thomas K. Baker, George H. Searfoss, Brianna M Paisley, Bartley W. Halstead, Steven K. Engle
Publikováno v:
Translating Molecules into Medicines ISBN: 9783319500409
Early safety assessment efforts from target identification to lead development have undergone rapid growth and evolution over the last 10 years. In this chapter, we will discuss the current development trends driving the need for early safety assessm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db81cb399fbb81e8cb881fc9cd8859e6
https://doi.org/10.1007/978-3-319-50042-3_5
https://doi.org/10.1007/978-3-319-50042-3_5
Autor:
Melanie Huffman, Armando R. Irizarry, Adam West, George H. Searfoss, Hui-Rong Qian, Shuyu Li, James L. Stevens, Hong Gao, John P. Stutz, Bartley W. Halstead, Thomas K. Baker, Robert A. Jolly, Yin Guo, John N. Calley, Timothy P. Ryan
Publikováno v:
Toxicological Sciences. 96:294-309
Marked species-specific responses to agonists of the peroxisome proliferator-activated alpha receptor (PPAR alpha) have been observed in rats and dogs, two species typically used to assess the potential human risk of pharmaceuticals in development. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34241083590d5d8c3dc5d6103f7c4bb3
https://doi.org/10.1093/toxsci/kfm009
https://doi.org/10.1093/toxsci/kfm009
Publikováno v:
Expert Opinion on Drug Metabolism & Toxicology. 2:687-696
Drug-induced phospholipidosis is the cytoplasmic accumulation of phospholipids as a result of xenobiotic exposure. This accumulation results in a unique histological effect in cells noted as electron-dense lamellar inclusions or whorls in the cytopla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::248239cc215e921aa07595c86aeeccfd
https://doi.org/10.1517/17425255.2.5.687
https://doi.org/10.1517/17425255.2.5.687
Autor:
David Monteith, Bartley W. Halstead, Brian R. Berridge, Craig E. Thomas, Ryan E. Morgan, Rita K. Bowers, Craig Zwickl
Publikováno v:
Journal of Applied Toxicology. 26:169-177
Phospholipidosis, or intracellular accumulation of phospholipids, is caused by specific classes of xenobiotics. This phenomenon represents a challenge for risk assessment that could benefit from the use of biomarkers in the clinical development of ne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eac9b6a7053f671470fbb36611bb773
https://doi.org/10.1002/jat.1120
https://doi.org/10.1002/jat.1120
Autor:
Ronald K. Newton, Baohui Li, Julie L. Altizer, J. Thorn Deahl, David Monteith, Ibrahim Kadura, Mohammed Islaih, Bartley W. Halstead, Jaclyn L. Reid-Hubbard, Leah Flick, David E. Watson
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 578:100-116
Genotoxic stress causes a variety of cellular and molecular responses in mammalian cells, including cell cycle arrest, DNA repair, and apoptosis. These responses result from the interplay between the genotoxic events themselves, and the biological co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0ab8b9deb2f7594ae373d140221692e
https://doi.org/10.1016/j.mrfmmm.2005.04.012
https://doi.org/10.1016/j.mrfmmm.2005.04.012