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Molecular dissection of cobra venom highlights heparinoids as an antidote for spitting cobra envenoming.

Autor: Du TY; Charles Perkins Centre, Dr. John and Anne Chong Lab for Functional Genomics, and School of Life and Environmental Sciences, University of Sydney, Camperdown, NSW 2006, Australia., Hall SR; Centre for Snakebite Research and Interventions, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, Liverpool, UK., Chung F; Charles Perkins Centre, Dr. John and Anne Chong Lab for Functional Genomics, and School of Life and Environmental Sciences, University of Sydney, Camperdown, NSW 2006, Australia., Kurdyukov S; Charles Perkins Centre, Dr. John and Anne Chong Lab for Functional Genomics, and School of Life and Environmental Sciences, University of Sydney, Camperdown, NSW 2006, Australia., Crittenden E; Centre for Snakebite Research and Interventions, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, Liverpool, UK., Patel K; School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2008, Australia., Dawson CA; Centre for Snakebite Research and Interventions, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, Liverpool, UK., Westhorpe AP; Centre for Snakebite Research and Interventions, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, Liverpool, UK., Bartlett KE; Centre for Snakebite Research and Interventions, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, Liverpool, UK., Rasmussen SA; Department of Pathology and Laboratory Medicine, Queen Elizabeth II Health Sciences Centre and Dalhousie University, 7th Floor of MacKenzie Building, 5788 University Avenue, Halifax, NS B3H 1V8, Canada., Moreno CL; Charles Perkins Centre, Dr. John and Anne Chong Lab for Functional Genomics, and School of Life and Environmental Sciences, University of Sydney, Camperdown, NSW 2006, Australia., Denes CE; Charles Perkins Centre, Dr. John and Anne Chong Lab for Functional Genomics, and School of Life and Environmental Sciences, University of Sydney, Camperdown, NSW 2006, Australia., Albulescu LO; Centre for Snakebite Research and Interventions, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, Liverpool, UK., Marriott AE; Centre for Snakebite Research and Interventions, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, Liverpool, UK., Mackay JP; School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2008, Australia., Wilkinson MC; Centre for Snakebite Research and Interventions, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, Liverpool, UK., Gutiérrez JM; Clodomiro Picado Institute, School of Microbiology, University of Costa Rica, P.O. Box 15501, 11501-2060 San José, Costa Rica., Casewell NR; Centre for Snakebite Research and Interventions, Department of Tropical Disease Biology, Liverpool School of Tropical Medicine, Pembroke Place, L3 5QA, Liverpool, UK., Neely GG; Charles Perkins Centre, Dr. John and Anne Chong Lab for Functional Genomics, and School of Life and Environmental Sciences, University of Sydney, Camperdown, NSW 2006, Australia.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Jul 17; Vol. 16 (756), pp. eadk4802. Date of Electronic Publication: 2024 Jul 17.

Repurposed drugs and their combinations prevent morbidity-inducing dermonecrosis caused by diverse cytotoxic snake venoms.

Autor: Hall SR; Centre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK.; Centre for Drugs & Diagnostics, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK., Rasmussen SA; Department of Pathology and Laboratory Medicine, Queen Elizabeth II Health Sciences Centre and Dalhousie University, 7th Floor of MacKenzie Building, 5788 University Avenue, Halifax, NS, B3H 1V8, Canada., Crittenden E; Centre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK., Dawson CA; Centre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK., Bartlett KE; Centre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK., Westhorpe AP; Centre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK., Albulescu LO; Centre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK.; Centre for Drugs & Diagnostics, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK., Kool J; Division of BioAnalytical Chemistry, Amsterdam Institute of Molecular and Life Sciences (AIMMS), Vrije Universiteit Amsterdam, De Boelelaan 1085, 1081 HV, Amsterdam, The Netherlands.; Centre for Analytical Sciences Amsterdam (CASA), 1098 XH, Amsterdam, The Netherlands., Gutiérrez JM; Instituto Clodomiro Picado, Facultad de Microbiología, Universidad de Costa Rica, PO Box 11501-2060, San José, Costa Rica., Casewell NR; Centre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK. nicholas.casewell@lstmed.ac.uk.; Centre for Drugs & Diagnostics, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK. nicholas.casewell@lstmed.ac.uk.

Publikováno v: Nature communications [Nat Commun] 2023 Dec 14; Vol. 14 (1), pp. 7812. Date of Electronic Publication: 2023 Dec 14.

Proteomics and histological assessment of an organotypic model of human skin following exposure to Naja nigricollis venom.

Autor: Ahmadi S; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Pachis ST; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Kalogeropoulos K; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., McGeoghan F; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Canbay V; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Hall SR; Centre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom., Crittenden EP; Centre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom., Dawson CA; Centre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom., Bartlett KE; Centre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom., Gutiérrez JM; Instituto Clodomiro Picado, Facultad de Microbiología Universidad de Costa Rica, San José, Costa Rica., Casewell NR; Centre for Snakebite Research & Interventions, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, United Kingdom., Keller UAD; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark., Laustsen AH; Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. Electronic address: ahola@bio.dtu.dk.

Publikováno v: Toxicon : official journal of the International Society on Toxinology [Toxicon] 2022 Dec; Vol. 220, pp. 106955. Date of Electronic Publication: 2022 Oct 27.