Výsledky vyhledávání - "Bartholomé Delort"

Structure and dynamics of G protein-coupled receptor–bound ghrelin reveal the critical role of the octanoyl chain

Autor: Pascal Demange, Maxime Louet, Alain Milon, Jacky Marie, Guillaume Ferré, Georges Czaplicki, Jean-Louis Banères, Pedro Renault, Laurent Gavara, Nicolas Floquet, Céline M'Kadmi, Sonia Cantel, Jean-Alain Fehrentz, Bartholomé Delort, Oliver Saurel, Marjorie Damian

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 2019, 116 (35), pp.17525-17530. ⟨10.1073/pnas.1905105116⟩
Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (35), pp.17525-17530. ⟨10.1073/pnas.1905105116⟩

Ghrelin plays a central role in controlling major biological processes. As for other G protein-coupled receptor (GPCR) peptide agonists, the structure and dynamics of ghrelin bound to its receptor remain obscure. Using a combination of solution-state

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbbcacfa3f0afdf98c0d03a456af2291
https://hal.archives-ouvertes.fr/hal-02322092

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GHSR-D2R heteromerization modulates dopamine signaling through an effect on G protein conformation

The growth hormone secretagogue receptor (GHSR) and dopamine receptor (D2R) have been shown to oligomerize in hypothalamic neurons with a significant effect on dopamine signaling, but the molecular processes underlying this effect are still obscure.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eeb0971c451af133a6524f9bace79bd7
https://hal.archives-ouvertes.fr/hal-02322168

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Use of Molecular Modeling to Design Selective NTS2 Neurotensin Analogues

Autor: Mélanie Vivancos, Jean-Michel Longpré, Jean Martinez, Bartholomé Delort, Philippe Sarret, Florine Cavelier, Roberto Fanelli, Élie Besserer-Offroy, Nicolas Floquet, Pedro Renault

Publikováno v: Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2017, 60 (8), pp.3303-3313. ⟨10.1021/acs.jmedchem.6b01848⟩

Neurotensin exerts potent analgesia by acting at both NTS1 and NTS2 receptors, whereas NTS1 activation also results in other physiological effects such as hypotension and hypothermia. Here, we used molecular modeling approach to design highly selecti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43b35e41d32c7d9229a7fa1dee6445d9
https://hal.archives-ouvertes.fr/hal-02322191

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Coarse-Grained Prediction of Peptide Binding to G-Protein Coupled Receptors

Autor: Landry Charlier, Pedro Renault, Jean Martinez, Florent Raussin, Bartholomé Delort, Nicolas Floquet

Publikováno v: Journal of Chemical Information and Modeling
Journal of Chemical Information and Modeling, American Chemical Society, 2017, 57 (3), pp.562-571. ⟨10.1021/acs.jcim.6b00503⟩

In this study, we used the Martini Coarse-Grained model with no applied restraints to predict the binding mode of some peptides to G-Protein Coupled Receptors (GPCRs). Both the Neurotensin-1 and the chemokine CXCR4 receptors were used as test cases.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082dbf916f4b57bdcf009d006a7734ce
https://pubmed.ncbi.nlm.nih.gov/28230370

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