Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Barth D Grant"'
Autor:
Guoqiang Wang, Ryan J Guasp, Sangeena Salam, Edward Chuang, Andrés Morera, Anna J Smart, David Jimenez, Sahana Shekhar, Emily Friedman, Ilija Melentijevic, Ken C Nguyen, David H Hall, Barth D Grant, Monica Driscoll
Publikováno v:
eLife, Vol 13 (2024)
Large vesicle extrusion from neurons may contribute to spreading pathogenic protein aggregates and promoting inflammatory responses, two mechanisms leading to neurodegenerative disease. Factors that regulate the extrusion of large vesicles, such as e
Externí odkaz:
https://doaj.org/article/c7cece9d67354cd59c1a7a7f1b5a4181
Autor:
Sravanthi S P Nadiminti, Shirley B Dixit, Neena Ratnakaran, Anushka Deb, Sneha Hegde, Sri Padma Priya Boyanapalli, Sierra Swords, Barth D Grant, Sandhya P Koushika
Publikováno v:
PLoS Genetics, Vol 20, Iss 5, p e1011253 (2024)
Synaptic vesicle proteins (SVps) are transported by the motor UNC-104/KIF1A. We show that SVps travel in heterogeneous carriers in C. elegans neuronal processes, with some SVp carriers co-transporting lysosomal proteins (SV-lysosomes). LRK-1/LRRK2 an
Externí odkaz:
https://doaj.org/article/f351698fe66249449565fcdd74304d3b
Autor:
Braveen B Joseph, Naava Naslavsky, Shaonil Binti, Sylvia Conquest, Lexi Robison, Ge Bai, Rafael O Homer, Barth D Grant, Steve Caplan, David S Fay
Publikováno v:
PLoS Genetics, Vol 19, Iss 4, p e1010741 (2023)
Human NIMA-related kinases have primarily been studied for their roles in cell cycle progression (NEK1/2/6/7/9), checkpoint-DNA-damage control (NEK1/2/4/5/10/11), and ciliogenesis (NEK1/4/8). We previously showed that Caenorhabditis elegans NEKL-2 (N
Externí odkaz:
https://doaj.org/article/609bdefd512d47deb4e70e27513c69db
Autor:
Yu Wang, Meghan Lee Arnold, Anna Joelle Smart, Guoqiang Wang, Rebecca J Androwski, Andres Morera, Ken CQ Nguyen, Peter J Schweinsberg, Ge Bai, Jason Cooper, David H Hall, Monica Driscoll, Barth D Grant
Publikováno v:
eLife, Vol 12 (2023)
Caenorhabditis elegans neurons under stress can produce giant vesicles, several microns in diameter, called exophers. Current models suggest that exophers are neuroprotective, providing a mechanism for stressed neurons to eject toxic protein aggregat
Externí odkaz:
https://doaj.org/article/f03cd4354e174bee8cd967a06a26154e
Publikováno v:
PLoS Genetics, Vol 18, Iss 10, p e1010296 (2022)
After endocytosis, transmembrane cargo is differentially sorted into degradative or recycling pathways. This process is facilitated by recruitment into physically distinct degradative or recycling microdomains on the limiting membrane of individual e
Externí odkaz:
https://doaj.org/article/f8ce1d14bc934d50bc5b1b78d31f48be
Autor:
Leo T H Tang, Meera Trivedi, Jenna Freund, Christopher J Salazar, Maisha Rahman, Nelson J Ramirez-Suarez, Garrett Lee, Yu Wang, Barth D Grant, Hannes E Bülow
Publikováno v:
PLoS Genetics, Vol 17, Iss 7, p e1009475 (2021)
The assembly of neuronal circuits involves the migrations of neurons from their place of birth to their final location in the nervous system, as well as the coordinated growth and patterning of axons and dendrites. In screens for genes required for p
Externí odkaz:
https://doaj.org/article/540ad2045ac0405191519c82dd7f4017
Publikováno v:
PLoS Genetics, Vol 16, Iss 2, p e1008633 (2020)
Endocytosis, the process by which cells internalize plasma membrane and associated cargo, is regulated extensively by posttranslational modifications. Previous studies suggested the potential involvement of scores of protein kinases in endocytic cont
Externí odkaz:
https://doaj.org/article/6636178b24ee425db5368c1f5b5419a8
Autor:
Peixiang Wang, Hang Liu, Yu Wang, Ou Liu, Jing Zhang, Adenrele Gleason, Zhenrong Yang, Hui Wang, Anbing Shi, Barth D Grant
Publikováno v:
PLoS Genetics, Vol 12, Iss 6, p e1006093 (2016)
EHBP-1 (Ehbp1) is a conserved regulator of endocytic recycling, acting as an effector of small GTPases including RAB-10 (Rab10). Here we present evidence that EHBP-1 associates with tubular endosomal phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2]
Externí odkaz:
https://doaj.org/article/ba1d73f3d0a44345ab05b70334f7ea12
Autor:
Ou Liu, Barth D Grant
Publikováno v:
PLoS Genetics, Vol 11, Iss 9, p e1005514 (2015)
The small GTPase RAB-5/Rab5 is a master regulator of the early endosome, required for a myriad of coordinated activities, including the degradation and recycling of internalized cargo. Here we focused on the recycling function of the early endosome a
Externí odkaz:
https://doaj.org/article/3e0cb55730644817b3737d689fec0186
Autor:
Mingyu Gu, Qiang Liu, Shigeki Watanabe, Lin Sun, Gunther Hollopeter, Barth D Grant, Erik M Jorgensen
Publikováno v:
eLife, Vol 2 (2013)
The clathrin adaptor complex AP2 is thought to be an obligate heterotetramer. We identify null mutations in the α subunit of AP2 in the nematode Caenorhabditis elegans. α-adaptin mutants are viable and the remaining μ2/β hemicomplex retains some
Externí odkaz:
https://doaj.org/article/7dbb98ede5df41b7b5de629133bdcd94