Acute myeloid leukemia stratifies as 2 clinically relevant sphingolipidomic subtypes.

Autor: Paudel BB; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA., Tan SF; Department of Medicine, Division of Hematology & Oncology, University of Virginia, Charlottesville, VA., Fox TE; Department of Pharmacology, University of Virginia, Charlottesville, VA., Ung J; Department of Medicine, Division of Hematology & Oncology, University of Virginia, Charlottesville, VA.; Department of Microbiology/Immunology/Cancer Biology, University of Virginia, Charlottesville, VA., Golla U; Department of Medicine, Division of Hematology and Oncology, Pennsylvania State University College of Medicine, Hershey, PA., Shaw JJP; Department of Medicine, Division of Hematology & Oncology, University of Virginia, Charlottesville, VA., Dunton W; Department of Medicine, Division of Hematology & Oncology, University of Virginia, Charlottesville, VA., Lee I; Department of Medicine, Division of Hematology & Oncology, University of Virginia, Charlottesville, VA.; Department of Internal Medicine, Baylor College of Medicine, Houston, TX., Fares WA; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA., Patel S; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA., Sharma A; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Cancer Institute, Hershey, PA., Viny AD; Department of Medicine, Division of Hematology & Oncology, and of Genetics & Development, Herbert Irving Comprehensive Cancer Center, New York, NY.; Columbia Stem Cell Initiative, Columbia University Irving Medical Center, New York, NY., Barth BM; Department of Chemistry, Biology, and Health Sciences, South Dakota School of Mines and Technology, Rapid City, SD.; Department of Natural Sciences, University of Alaska Southeast, Juneau, AK., Tallman MS; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL., Cabot M; Department of Biochemistry & Molecular Biology, East Carolina University, Greenville, NC.; East Carolina Diabetes and Obesity Institute, Brody School of Medicine, East Carolina University, Greenville, NC., Garrett-Bakelman FE; Department of Medicine, Division of Hematology & Oncology, University of Virginia, Charlottesville, VA.; Department of Biochemistry & Molecular Genetics, University of Virginia, Charlottesville, VA.; University of Virginia Cancer Center, Charlottesville, VA., Levine RL; Human Oncology and Pathogenesis Program and Leukemia Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Kester M; Department of Pharmacology, University of Virginia, Charlottesville, VA., Feith DJ; Department of Medicine, Division of Hematology & Oncology, University of Virginia, Charlottesville, VA.; University of Virginia Cancer Center, Charlottesville, VA., Claxton D; Department of Medicine, Division of Hematology and Oncology, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Cancer Institute, Hershey, PA., Janes KA; Department of Biomedical Engineering, University of Virginia, Charlottesville, VA.; Department of Biochemistry & Molecular Genetics, University of Virginia, Charlottesville, VA.; University of Virginia Cancer Center, Charlottesville, VA., Loughran TP Jr; Department of Medicine, Division of Hematology & Oncology, University of Virginia, Charlottesville, VA.; University of Virginia Cancer Center, Charlottesville, VA.

Publikováno v: Blood advances [Blood Adv] 2024 Mar 12; Vol. 8 (5), pp. 1137-1142.

Obesity Promotes the Ceramide-Mediated NADPH Oxidase in Acute Myeloid Leukemia.

Autor: Wang W; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA.; Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta GA 30322 USA., Sabol RJ; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA., Day AM; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA., Hathorn TG; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA., Clark MN; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA., Connell SE; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA., Mantis EA; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA., Traore M; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA., Siciliano JM; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA., Arsenault EJ; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA., Labrecque NT; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA., Sullivan EC; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA., Cote AL; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA.; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139 USA.; The Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, MA 02139 USA., Toran PT; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA., Barth BM; Department of Molecular, Cellular, and Biomedical Sciences, University of New Hampshire, Durham, NH 03824 USA.; Department of Natural Sciences, University of Alaska Southeast, Juneau, AK 99801 USA.

Publikováno v: Journal of blood disorders and malignancies [J Blood Disord Malig] 2024; Vol. 2 (1). Date of Electronic Publication: 2024 Apr 15.

Ceramide: improving Bcl-2 inhibitor therapy.

Autor: Barth BM; South Dakota School of Mines and Technology.

Publikováno v: Blood [Blood] 2022 Jun 30; Vol. 139 (26), pp. 3676-3678.

The Role of the Microbiome in Cancer and the Development of Cancer Therapeutics.

Autor: Belknap KC; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham NH 03824 USA., Cote AL; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham NH 03824 USA., McGill CM; Department of Chemistry, University of Alaska Anchorage, Anchorage AK 99508 USA., Andam CP; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham NH 03824 USA.; Department of Biological Sciences, University at Albany, State University of New York, Albany, NY 12222 USA., Barth BM; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham NH 03824 USA.

Publikováno v: International journal of biopharmaceutical sciences [Int J Biopharm Sci] 2020 Sep; Vol. 2 (1). Date of Electronic Publication: 2020 Sep 05.

Sphingolipid metabolism determines the therapeutic efficacy of nanoliposomal ceramide in acute myeloid leukemia.

Autor: Barth BM; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH.; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA., Wang W; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH., Toran PT; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH., Fox TE; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA.; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA., Annageldiyev C; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA., Ondrasik RM; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA., Keasey NR; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA., Brown TJ; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA.; Department of Medicine, University of Texas Southwestern Medical Center, Dallas, TX., Devine VG; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA., Sullivan EC; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH., Cote AL; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH., Papakotsi V; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH., Tan SF; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA.; Division of Hematology and Oncology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA.; University of Virginia Cancer Center, Charlottesville, VA., Shanmugavelandy SS; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA., Deering TG; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA., Needle DB; Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham, NH., Stern ST; Nanotechnology Characterization Laboratory, Advanced Technology Program, SAIC-Frederick, Inc., National Cancer Institute-Frederick National Laboratory for Cancer Research, Frederick, MD., Zhu J; Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA., Liao J; Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, PA., Viny AD; Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Feith DJ; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA.; Division of Hematology and Oncology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA.; University of Virginia Cancer Center, Charlottesville, VA., Levine RL; Human Oncology and Pathogenesis Program, Leukemia Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY., Wang HG; Penn State Hershey Cancer Institute, Hershey, PA.; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA.; Pediatric Molecular Oncology Program, Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, PA; and., Loughran TP Jr; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA.; Division of Hematology and Oncology, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA.; University of Virginia Cancer Center, Charlottesville, VA., Sharma A; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA.; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA., Kester M; Penn State Hershey Cancer Institute, Hershey, PA.; Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA.; Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA.; University of Virginia Cancer Center, Charlottesville, VA.; nanoSTAR Institute, University of Virginia, Charlottesville, VA., Claxton DF; Division of Hematology and Oncology, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA.; Penn State Hershey Cancer Institute, Hershey, PA.

Publikováno v: Blood advances [Blood Adv] 2019 Sep 10; Vol. 3 (17), pp. 2598-2603.