Dysregulation of zebrin-II cell subtypes in the cerebellum is a shared feature across polyglutamine ataxia mouse models and patients.

Autor: Bartelt LC; University Program in Genetics & Genomics, Duke University Medical Center, Durham, NC 27710, USA.; Departments of Pathology & Laboratory Medicine, Neurology, Biological Chemistry, and Neurobiology & Behavior, University of California, Irvine, Irvine, CA 92697, USA.; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA., Switonski PM; Department of Neuronal Cell Biology, Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland., Adamek G; Department of Neuronal Cell Biology, Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland., Longo F; Departments of Pathology & Laboratory Medicine, Neurology, Biological Chemistry, and Neurobiology & Behavior, University of California, Irvine, Irvine, CA 92697, USA., Carvalho J; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA., Duvick LA; Institute for Translational Neuroscience, and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA., Jarrah SI; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA., McLoughlin HS; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA., Scoles DR; Department of Neurology, University of Utah, Salt Lake City, UT 84132, USA., Pulst SM; Department of Neurology, University of Utah, Salt Lake City, UT 84132, USA., Orr HT; Institute for Translational Neuroscience, and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA., Hull C; Department of Neurobiology, Duke University School of Medicine, Durham, NC 27710, USA., Lowe CB; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA., La Spada AR; Departments of Pathology & Laboratory Medicine, Neurology, Biological Chemistry, and Neurobiology & Behavior, University of California, Irvine, Irvine, CA 92697, USA.; Department of Neurology, Duke University School of Medicine, Durham, NC 27710, USA.; UCI Center for Neurotherapeutics, University of California, Irvine, Irvine, CA 92697, USA.

Publikováno v: Science translational medicine [Sci Transl Med] 2024 Nov 06; Vol. 16 (772), pp. eadn5449. Date of Electronic Publication: 2024 Nov 06.

Cooperative regulation of coupled oncoprotein synthesis and stability in triple-negative breast cancer by EGFR and CDK12/13.

Autor: Ang HX; Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC 22710., Sutiman N; Duke-National University of Singapore Medical School, Singapore 169857, Singapore., Deng XL; Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC 22710., Liu A; Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC 22710.; Department of Surgery, Duke University School of Medicine, Durham, NC 22710., Cerda-Smith CG; Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC 22710., Hutchinson HM; Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC 22710., Kim H; Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC 22710., Bartelt LC; Duke Center for Genomic and Computational Biology, Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC 27708., Chen Q; Department of Cell Biology, Duke University School of Medicine, Durham, NC 22710., Barrera A; Duke Center for Genomic and Computational Biology, Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC 27708.; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC 27708., Lin J; Bioinformatics Shared Resources, Duke Cancer Institute, Duke University Medical Center, Durham, NC 27705., Sheng Z; Bioinformatics Shared Resources, Duke Cancer Institute, Duke University Medical Center, Durham, NC 27705., McDowell IC; Duke Center for Genomic and Computational Biology, Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC 27708.; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC 27708., Reddy TE; Duke Center for Genomic and Computational Biology, Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC 27708.; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC 27708., Nicchitta CV; Department of Cell Biology, Duke University School of Medicine, Durham, NC 22710., Wood KC; Department of Pharmacology & Cancer Biology, Duke University School of Medicine, Durham, NC 22710.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2023 Sep 19; Vol. 120 (38), pp. e2221448120. Date of Electronic Publication: 2023 Sep 11.

Purkinje-Enriched snRNA-seq in SCA7 Cerebellum Reveals Zebrin Identity Loss as a Central Feature of Polyglutamine Ataxias.

Autor: Bartelt LC; University Program in Genetics & Genomics, Duke University Medical Center, Durham, NC 27710, USA.; Departments of Pathology & Laboratory Medicine, Neurology, Biological Chemistry, and Neurobiology & Behavior, University of California, Irvine; Irvine, CA 92697, USA.; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA., Switonski PM; Department of Medical Biotechnology, Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland., Adamek G; Department of Medical Biotechnology, Institute of Bioorganic Chemistry, Polish Academy of Sciences, 61-704 Poznan, Poland., Carvalho J; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA., Duvick LA; Institute for Translational Neuroscience, and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA., Jarrah SI; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA., McLoughlin HS; Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA., Scoles DR; Department of Neurology, University of Utah, Salt Lake City, UT 84132, USA., Pulst SM; Department of Neurology, University of Utah, Salt Lake City, UT 84132, USA., Orr HT; Institute for Translational Neuroscience, and Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, USA., Hull C; Department of Neurobiology, Duke University School of Medicine, Durham, NC 27710, USA., Lowe CB; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC 27710, USA., La Spada AR; Departments of Pathology & Laboratory Medicine, Neurology, Biological Chemistry, and Neurobiology & Behavior, University of California, Irvine; Irvine, CA 92697, USA.; Department of Neurology, Duke University School of Medicine, Durham, NC 27710, USA.; UCI Center for Neurotherapeutics, University of California, Irvine; Irvine, CA 92697, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 May 11. Date of Electronic Publication: 2023 May 11.

Single-nucleus transcriptional profiling of GAD2-positive neurons from mouse lateral habenula reveals distinct expression of neurotransmission- and depression-related genes.

Autor: Green MV; Department of Neurobiology, Duke University, Durham NC 27710., Gallegos DA; Department of Neurobiology, Duke University, Durham NC 27710., Boua JV; Department of Neurobiology, Duke University, Durham NC 27710., Bartelt LC; Department of Neurobiology, Duke University, Durham NC 27710., Narayanan A; Department of Neurobiology, Duke University, Durham NC 27710., West AE; Department of Neurobiology, Duke University, Durham NC 27710.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Jan 09. Date of Electronic Publication: 2023 Jan 09.

Transgenic mice for in vivo epigenome editing with CRISPR-based systems.

Autor: Gemberling MP; Department of Biomedical Engineering, Duke University, Durham, NC, USA.; Center for Advanced Genomic Technologies, Duke University, Durham, NC, USA., Siklenka K; Center for Advanced Genomic Technologies, Duke University, Durham, NC, USA.; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA., Rodriguez E; Department of Neurobiology, Duke University School of Medicine, Durham, NC, USA., Tonn-Eisinger KR; Department of Neurobiology, Duke University School of Medicine, Durham, NC, USA., Barrera A; Center for Advanced Genomic Technologies, Duke University, Durham, NC, USA.; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA., Liu F; Department of Neurobiology, Duke University School of Medicine, Durham, NC, USA., Kantor A; Department of Biomedical Engineering, Duke University, Durham, NC, USA.; Center for Advanced Genomic Technologies, Duke University, Durham, NC, USA., Li L; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA., Cigliola V; Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; Regeneration Next Initiative, Duke University, Durham, NC, USA., Hazlett MF; Department of Neurobiology, Duke University School of Medicine, Durham, NC, USA., Williams CA; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA., Bartelt LC; Center for Advanced Genomic Technologies, Duke University, Durham, NC, USA.; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA., Madigan VJ; Department of Surgery, Duke University Medical Center, Durham, NC, USA., Bodle JC; Department of Biomedical Engineering, Duke University, Durham, NC, USA.; Center for Advanced Genomic Technologies, Duke University, Durham, NC, USA., Daniels H; Department of Biomedical Engineering, Duke University, Durham, NC, USA.; Center for Advanced Genomic Technologies, Duke University, Durham, NC, USA., Rouse DC; Division of Laboratory Animal Resources, Duke University School of Medicine, Durham, NC, USA., Hilton IB; Department of Biomedical Engineering, Duke University, Durham, NC, USA.; Department of Bioengineering, Rice University, Houston, TX, USA.; Department of Biosciences, Rice University, Houston, TX, USA., Asokan A; Department of Biomedical Engineering, Duke University, Durham, NC, USA.; Center for Advanced Genomic Technologies, Duke University, Durham, NC, USA.; Regeneration Next Initiative, Duke University, Durham, NC, USA.; Department of Surgery, Duke University Medical Center, Durham, NC, USA.; Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA., Ciofani M; Center for Advanced Genomic Technologies, Duke University, Durham, NC, USA.; Department of Immunology, Duke University Medical Center, Durham, NC, USA., Poss KD; Center for Advanced Genomic Technologies, Duke University, Durham, NC, USA.; Department of Cell Biology, Duke University Medical Center, Durham, NC, USA.; Regeneration Next Initiative, Duke University, Durham, NC, USA., Reddy TE; Center for Advanced Genomic Technologies, Duke University, Durham, NC, USA.; Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA., West AE; Center for Advanced Genomic Technologies, Duke University, Durham, NC, USA.; Department of Neurobiology, Duke University School of Medicine, Durham, NC, USA., Gersbach CA; Department of Biomedical Engineering, Duke University, Durham, NC, USA. charles.gersbach@duke.edu.; Center for Advanced Genomic Technologies, Duke University, Durham, NC, USA. charles.gersbach@duke.edu.; Department of Cell Biology, Duke University Medical Center, Durham, NC, USA. charles.gersbach@duke.edu.; Regeneration Next Initiative, Duke University, Durham, NC, USA. charles.gersbach@duke.edu.; Department of Surgery, Duke University Medical Center, Durham, NC, USA. charles.gersbach@duke.edu.

Publikováno v: Nature methods [Nat Methods] 2021 Aug; Vol. 18 (8), pp. 965-974. Date of Electronic Publication: 2021 Aug 02.