Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody.

Autor: Sunita Gulati, Frank J Beurskens, Bart-Jan de Kreuk, Marcel Roza, Bo Zheng, Rosane B DeOliveira, Jutamas Shaughnessy, Nancy A Nowak, Ronald P Taylor, Marina Botto, Xianbao He, Robin R Ingalls, Trent M Woodruff, Wen-Chao Song, Janine Schuurman, Peter A Rice, Sanjay Ram

Publikováno v: PLoS Biology, Vol 17, Iss 6, p e3000323 (2019)

Multidrug-resistant Neisseria gonorrhoeae is a global health problem. Monoclonal antibody (mAb) 2C7 recognizes a gonococcal lipooligosaccharide epitope that is expressed by >95% of clinical isolates and hastens gonococcal vaginal clearance in mice. C

Externí odkaz: https://doaj.org/article/d50d01ed75774b0d843c0e7549972158

Heart of glass anchors Rasip1 at endothelial cell-cell junctions to support vascular integrity

Autor: Bart-Jan de Kreuk, Alexandre R Gingras, James DR Knight, Jian J Liu, Anne-Claude Gingras, Mark H Ginsberg

Publikováno v: eLife, Vol 5 (2016)

Heart of Glass (HEG1), a transmembrane receptor, and Rasip1, an endothelial-specific Rap1-binding protein, are both essential for cardiovascular development. Here we performed a proteomic screen for novel HEG1 interactors and report that HEG1 binds d

Externí odkaz: https://doaj.org/article/dcda1f2adf504976a355377abd7c7903

Complement alone drives efficacy of a chimeric antigonococcal monoclonal antibody

Autor: Trent M. Woodruff, Xianbao He, Jutamas Shaughnessy, Marcel Roza, Janine Schuurman, Frank J. Beurskens, Bart-Jan de Kreuk, Peter A. Rice, Robin R. Ingalls, Nancy A. Nowak, Wen-Chao Song, Sunita Gulati, Sanjay Ram, Bo Zheng, Ronald P. Taylor, Marina Botto, Rosane B. DeOliveira

Publikováno v: PLoS Biology
PLoS Biology, Vol 17, Iss 6, p e3000323 (2019)

Multidrug-resistant Neisseria gonorrhoeae is a global health problem. Monoclonal antibody (mAb) 2C7 recognizes a gonococcal lipooligosaccharide epitope that is expressed by >95% of clinical isolates and hastens gonococcal vaginal clearance in mice. C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e53b32e5caa49cb9b1f637e81cd869
http://hdl.handle.net/10044/1/71493

The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions

Autor: René J. P. Musters, Jeroen Kole, Anne-Marieke D. van Stalborch, Dirk Geerts, Kalim Nawaz, Stephan Huveneers, Nicolette S. Jansen, Johan de Rooij, Tsveta S. Malinova, Yvonne L. Dorland, Daphne van Geemen, Peter L. Hordijk, Bart-Jan de Kreuk, Adam G. Grieve

Publikováno v: Nature Communications, 7:12210
Nature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
Dorland, Y L, Malinova, T S, van Stalborch, A-M D, Grieve, A G, van Geemen, D, Jansen, N S, de Kreuk, B-J, Nawaz, K, Kole, J, Geerts, D, Musters, R J P, de Rooij, J, Hordijk, P L & Huveneers, S 2016, ' The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions ', Nature Communications, vol. 7, 12210 . https://doi.org/10.1038/ncomms12210
Nature Communications [E], 7. Nature Publishing Group
Nature Communications, 7
Nature Communications, 7:12210. Nature Publishing Group
Nature communications, 7. Nature Publishing Group
Nature Communications

Vascular homoeostasis, development and disease critically depend on the regulation of endothelial cell–cell junctions. Here we uncover a new role for the F-BAR protein pacsin2 in the control of VE-cadherin-based endothelial adhesion. Pacsin2 concen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e50732bf2f4d9ea3afb6235e5af16375
https://dspace.library.uu.nl/handle/1874/345340

The F-BAR Protein PACSIN2 Regulates Epidermal Growth Factor Receptor Internalization

Autor: Eloise C. Anthony, Dirk Geerts, Peter L. Hordijk, Bart-Jan de Kreuk

Publikováno v: De Kreuk, B J, Anthony, E C, Geertss, D & Hordijk, P L 2012, ' The F-BAR protein PACSIN2 regulates epidermal growth factor receptor internalization ', Journal of Biological Chemistry, vol. 287, no. 52, pp. 43438-43453 . https://doi.org/10.1074/jbc.M112.391078
Journal of biological chemistry, 287(52), 43438-43453. American Society for Biochemistry and Molecular Biology Inc.
Journal of Biological Chemistry, 287(52), 43438-43453. American Society for Biochemistry and Molecular Biology Inc.
Journal of Biological Chemistry, 287(52), 43438-53. American Society for Biochemistry and Molecular Biology Inc.

Signaling via growth factor receptors, including the epidermal growth factor (EGF) receptor, is key to various cellular processes, such as proliferation, cell survival, and cell migration. In a variety of human diseases such as cancer, aberrant expre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51b8a2c5f18e9119e3e5807d1395ad29
https://doi.org/10.1074/jbc.m112.391078