Výsledky vyhledávání - "Bart-Jan Wierenga"

Identification of USP7 as druggable target in non-canonical PRC1.1 for human leukemias

Autor: Chantal Gravesteijn, Vincent van den Boom, Bart-Jan Wierenga, Edo Vellenga, Henny Maat, Jan Jacob Schuringa

Publikováno v: Experimental Hematology. 44:S40-S41

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::24497ce0601d3aa58041b305f30d3194
https://doi.org/10.1016/j.exphem.2016.06.042

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Interleukin-6 production by activated human monocytic cells is enhanced by MK-571, a specific inhibitor of the multi-drug resistance protein-1

Autor: Bart-Jan Wierenga, Edo Vellenga, Leonore Tuyt, W. H. A. Dokter, Michael Müller

Publikováno v: British Journal of Pharmacology. 127:441-448

1. The intracellular transport of leukotriene C4 (LTC4) in hematopoietic cells such as human monocytes is controlled by an ATP dependent carrier encoded by the multidrug resistance protein1 (MRPI) gene whose function can be blocked by the compound MK

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f91ad9a9c234ec0823d9d36653248c7f
https://doi.org/10.1038/sj.bjp.0702577

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ERG and FLI1 binding sites demarcate targets for aberrant epigenetic regulation by AML1-ETO in acute myeloid leukemia

Autor: Lucia Altucci, Sadia Saeed, Hendrik G. Stunnenberg, Femke Simmer, Joost H.A. Martens, Edo Vellenga, Amit Mandoli, Bart-Jan Wierenga, Abhishek Singh

Publikováno v: Blood 120 (19) (2012): 4038–4048. doi:10.1182/blood-2012-05-429050
info:cnr-pdr/source/autori:Martens JH, Mandoli A, Simmer F, Wierenga BJ, Saeed S, Singh AA, Altucci L, Vellenga E, Stunnenberg HG./titolo:ERG and FLI1 binding sites demarcate targets for aberrant epigenetic regulation by AML1-ETO in acute myeloid leukemia./doi:10.1182%2Fblood-2012-05-429050/rivista:Blood/anno:2012/pagina_da:4038/pagina_a:4048/intervallo_pagine:4038–4048/volume:120 (19)
Blood, 120, 19, pp. 4038-4048
Blood, 120, 4038-4048
Blood, 120(19), 4038-4048. AMER SOC HEMATOLOGY

ERG and FLI1 are closely related members of the ETS family of transcription factors and have been identified as essential factors for the function and maintenance of normal hematopoietic stem cells. Here genome-wide analysis revealed that both ERG an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a8b9d9192d0a0a788553d5897ac1f7
https://doi.org/10.1182/blood-2012-05-429050

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Targeting Autophagy As a Potential Therapeutic Strategy for the Treatment of AML

Autor: Bart-Jan Wierenga, Hendrik Folkerts, Paul J. Coffer, Jan Jacob Schuringa, Edo Vellenga

Publikováno v: Blood, 126(23). AMER SOC HEMATOLOGY

Autophagy is a catabolic process whereby redundant organelles and proteins are digested and recycled to maintain cellular homeostasis. Malignant cells might activate autophagy in response to cellular stress, and/or to provide metabolites required for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9065f302fe6f77bf81ce98e9da3fbef4
https://doi.org/10.1182/blood.v126.23.3831.3831

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CBFB-MYH11/RUNX1 together with a compendium of hematopoietic regulators, chromatin modifiers and basal transcription factors occupies self-renewal genes in inv(16) acute myeloid leukemia

Autor: Joost Martens, Amit Mandoli, Abhishek Singh, Pascal Jansen, Bart-Jan Wierenga, Human Riahi, Gianluigi Franci, Koen Prange, Sadia Saeed, Edo Vellenga, Michiel Vermeulen, Henk Stunnenberg

Publikováno v: Experimental Hematology, 41(8), S50-S50. ELSEVIER SCIENCE INC

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cb4c12c1f67587fedc6519fdf889d47
https://doi.org/10.1016/j.exphem.2013.05.198

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AML1/RUNX1, One of the Most Common Targets of Aberration in Acute Myeloid Leukemia as a Transcriptional Regulator of Vascular Endothelial Growth Factor (VEGFA)

Autor: Frank J. G. Scherpen, Evelina S. De Bont, Jenny Douwes, Willem A. Kamps, Bart-Jan Wierenga, Jan Jacob Schuringa, Bin Ma, Arja ter Elst

Publikováno v: Blood. 110:1618-1618

Cellular VEGFA is an independent adverse prognostic factor related to worse outcome in AML and is significantly upregulated in leukemic blasts (de bont ES. et al., 2002). Transcriptional activation of the VEGFA promoter represents the core mechanism

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::381cbd4331e1eb67b75bfbb2367b6ad5
https://doi.org/10.1182/blood.v110.11.1618.1618

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STAT5-Induced Self-Renewal and Impaired Myelopoiesis of Human Hematopoietic Stem/Progenitor Cells Involves Downmodulation of C/EBPα

Autor: Edo Vellenga, Malcolm A.S. Moore, Hein Schepers, Bart-Jan Wierenga, Jan Jacob Schuringa

Publikováno v: Blood. 106:268-268

Previously, we demonstrated that enforced activation of STAT5 in human cord blood (CB)-derived stem/progenitor cells results in enhanced long-term stem cell self-renewal and impaired myelopoiesis (J.J.Schuringa et al, J.Exp.Med. 2004;200:623). Now, C

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::98ee31a85b47fb967ccc5a17b7017afb
https://doi.org/10.1182/blood.v106.11.268.268

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