Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Bart-Jan Lichtenbelt"'
Autor:
Michel Struys, K. van Amsterdam, Anthony Absalom, T. De Smet, Douglas J. Eleveld, A V M van den Heerik, Thomas Scheeren, Bart Jan Lichtenbelt, J. P. van den Berg
Publikováno v:
British Journal of Anaesthesia, 119(5), 918-927. ELSEVIER SCI LTD
Background Target controlled infusion (TCI) systems use population-based pharmacokinetic (PK) models that do not take into account inter-individual residual variation. This study compares the bias and inaccuracy of a population-based vs a personalize
Publikováno v:
British Journal of Anaesthesia, 107(1), 38-47. ELSEVIER SCI LTD
This review discusses the ways in which anaesthetists can optimize anaesthetic-analgesic drug administration by utilizing pharmacokinetic and pharmacodynamic information. We therefore focus on the dose-response relationship and the interactions betwe
Autor:
Bart Jan Lichtenbelt, Erik Olofsen, Jaap Vuyk, Michel Struys, Jack W. van Kleef, Albert Dahan
Publikováno v:
Anesthesia and Analgesia, 110(6), 1597-1606. LIPPINCOTT WILLIAMS & WILKINS
Anesthesia and Analgesia, 110(6), 1597-1606
Anesthesia and Analgesia, 110(6), 1597-1606
BACKGROUND: Midazolam, at sedative levels, increases blood propofol concentrations by 25%. We evaluated the reverse interaction and determined the influence of propofol on the pharmacokinetics of midazolam.METHODS: Eight healthy male volunteers were
Publikováno v:
Clinical Pharmacokinetics. 43:577-593
Propofol-opioid combinations are widely used in today's anaesthetic practice. Over the past 20-30 years the pharmacology of these agents has been described in increasingly greater detail. Together with novel intravenous administration devices and imp
Publikováno v:
Anesthesia and Analgesia, 108(5), 1522-1530. LIPPINCOTT WILLIAMS & WILKINS
BACKGROUND: The combined administration of anesthetics has been associated with pharmacokinetic interactions that induce concentration changes of up to 30%. Midazolam is often used as a preoperative sedative in advance of a propofol-based anesthetic.
Autor:
Albert Dahan, Bart Jan Lichtenbelt, Anton G. L. Burm, Jenny Vieveen, Frank H. M. Engbers, Jaap Vuyk
Publikováno v:
Anesthesiology. 100(1)
THE Bispectral Index (BIS) is increasingly used to monitor the level of (un)consciousness during surgical anesthesia and conscious sedation. Generally, an intraoperative BIS of 40-60 is considered sufficient to maintain adequate hypnosis for surgery.
Publikováno v:
Anesthesiology. 101:800-801