Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Bart Van Lith"'
Autor:
Bonnie K Harrington, Heather L Gardner, Raquel Izumi, Ahmed Hamdy, Wayne Rothbaum, Kevin R Coombes, Todd Covey, Allard Kaptein, Michael Gulrajani, Bart Van Lith, Cecile Krejsa, Christopher C Coss, Duncan S Russell, Xiaoli Zhang, Bridget K Urie, Cheryl A London, John C Byrd, Amy J Johnson, William C Kisseberth
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159607 (2016)
Acalabrutinib (ACP-196) is a second-generation inhibitor of Bruton agammaglobulinemia tyrosine kinase (BTK) with increased target selectivity and potency compared to ibrutinib. In this study, we evaluated acalabrutinib in spontaneously occurring cani
Externí odkaz:
https://doaj.org/article/885fb92964b3445a99b5a10f0adb8206
Autor:
Marijn C. Meuwese, Hans L. Mooij, Max Nieuwdorp, Bart van Lith, Roos Marck, Hans Vink, John J.P. Kastelein, Erik S.G. Stroes
Publikováno v:
Journal of Lipid Research, Vol 50, Iss 1, Pp 148-153 (2009)
The endothelial glycocalyx has been shown to serve as a protective barrier between the flowing blood and the vessel wall in experimental models. The aim of this study was to evaluate whether hypercholesterolemia is associated with glycocalyx perturba
Externí odkaz:
https://doaj.org/article/68856bf8580e4685a9eeca6a4e9b47a0
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e32292 (2012)
Many plant seeds and invertebrates can survive passage through the digestive system of birds, which may lead to long distance dispersal (endozoochory) in case of prolonged retention by moving vectors. Endozoochorous dispersal by waterbirds has nowada
Externí odkaz:
https://doaj.org/article/74026e50bc054f9fb08c9e986940b602
Autor:
Terry, Podoll, Paul G, Pearson, Allard, Kaptein, Jerry, Evarts, Gerjan, de Bruin, Maaike, Emmelot-van Hoek, Anouk, de Jong, Bart, van Lith, Hao, Sun, Stephen, Byard, Adrian, Fretland, Niels, Hoogenboom, Tjeerd, Barf, J Greg, Slatter
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 384:173-186
Acalabrutinib is a covalent Bruton tyrosine kinase (BTK) inhibitor approved for relapsed/refractory mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma. A major metabolite of acalabrutinib (M27, ACP-5862) was observed in
Autor:
Tjeerd Barf, Bart Van Lith, Todd Covey, Dennis Demont, Niels Hoogenboom, Bas van de Kar, Saskia Verkaik, Allard Kaptein, Maaike van Hoek, Gerjan de Bruin, Michael Gulrajani, Edwin de Zwart
Publikováno v:
Bioorganicmedicinal chemistry letters. 30(14)
Bruton tyrosine kinase (BTK) is an important target in oncology and (auto)immunity. Various BTK inhibitors have been approved or are currently in clinical development. A novel BTK inhibitor series was developed starting with a quinazoline core. Movin
Autor:
Iván de la Hera, Simone Meddle, Barbara M. Tomotani, Bart van Lith, Christiaan Both, Marcel E. Visser, Cynthia Y. M. J. G. Lange
Publikováno v:
Journal of Experimental Biology, 222(17):jeb201467. The Company of Biologists Ltd
Tomotani, B, de la Hera, I, Lange, C Y M J G, van Lith, B, Meddle, S, Both, C & Visser, M E 2019, ' Timing manipulations reveal the lack of a causal link across annual cycle stages in a long distance migrant ', Journal of Experimental Biology . https://doi.org/10.1242/jeb.201467
The Journal of Experimental Biology, 222(17):jeb201467. COMPANY OF BIOLOGISTS LTD
Tomotani, B, de la Hera, I, Lange, C Y M J G, van Lith, B, Meddle, S, Both, C & Visser, M E 2019, ' Timing manipulations reveal the lack of a causal link across annual cycle stages in a long distance migrant ', Journal of Experimental Biology . https://doi.org/10.1242/jeb.201467
The Journal of Experimental Biology, 222(17):jeb201467. COMPANY OF BIOLOGISTS LTD
Organisms need to time their annual-cycle stages, like breeding and migration, to occur at the right time of the year. Climate change has shifted the timing of annual-cycle stages at different rates, thereby tightening or lifting time constraints of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d629fc6e4a18eaab754606e07d643534
https://pure.knaw.nl/portal/en/publications/d4e83552-8298-436e-9ce0-1f8cea1e7149
https://pure.knaw.nl/portal/en/publications/d4e83552-8298-436e-9ce0-1f8cea1e7149
Autor:
Veronika N. Laine, Heidi M. Viitaniemi, Kees van Oers, Marcel E. Visser, Phillip Gienapp, Ruben de Wit, Bart van Lith, Simone Meddle, Willem Kamphuis, Irene Verhagen, Samuel P. Caro, Tony D. Williams, Agata Pijl, A. Christa Mateman
Publikováno v:
Journal of Experimental Biology
Journal of Experimental Biology, Cambridge University Press, 2019, 222 (17), pp.jeb202481. ⟨10.1242/jeb.202481⟩
Journal of Experimental Biology, The Company of Biologists, 2019, 222 (17), pp.jeb202481. ⟨10.1242/jeb.202481⟩
Journal of Experimental Biology, 222(17)
Journal of Experimental Biology, 222:jeb.202481. The Company of Biologists Ltd
Verhagen, I, Laine, V N, Mateman, AC, Pijl, A, de Wit, R, van Lith, B, Kamphuis, W, Viitaniemi, HM, Williams, T D, Caro, SP, Meddle, S, Gienapp, P, van Oers, K & Visser, M E 2019, ' Fine-tuning of seasonal timing of breeding is regulated downstream in the underlying neuro-endocrine system in a small song bird ', Journal of Experimental Biology . https://doi.org/10.1242/jeb.202481
Journal of Experimental Biology 222 (2019) 17
Journal of Experimental Biology, 2019, 222 (17), pp.jeb202481. ⟨10.1242/jeb.202481⟩
Journal of Experimental Biology, Cambridge University Press, 2019, 222 (17), pp.jeb202481. ⟨10.1242/jeb.202481⟩
Journal of Experimental Biology, The Company of Biologists, 2019, 222 (17), pp.jeb202481. ⟨10.1242/jeb.202481⟩
Journal of Experimental Biology, 222(17)
Journal of Experimental Biology, 222:jeb.202481. The Company of Biologists Ltd
Verhagen, I, Laine, V N, Mateman, AC, Pijl, A, de Wit, R, van Lith, B, Kamphuis, W, Viitaniemi, HM, Williams, T D, Caro, SP, Meddle, S, Gienapp, P, van Oers, K & Visser, M E 2019, ' Fine-tuning of seasonal timing of breeding is regulated downstream in the underlying neuro-endocrine system in a small song bird ', Journal of Experimental Biology . https://doi.org/10.1242/jeb.202481
Journal of Experimental Biology 222 (2019) 17
Journal of Experimental Biology, 2019, 222 (17), pp.jeb202481. ⟨10.1242/jeb.202481⟩
International audience; The timing of breeding is under selection in wild populations as a result of climate change, and understanding the underlying physiological processes mediating this timing provides insight into the potential rate of adaptation
Autor:
Dennis Demont, Roger G. Ulrich, Tjeerd Barf, Raquel Izumi, Allard Kaptein, Bart Van Lith, Edwin de Zwart, Michael Gulrajani, Todd Covey, Saskia Verkaik, Paul G. Pearson, Diana Mittag, Bas van de Kar, Fanny Krantz, Maaike van Hoek
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 363(2)
Several small-molecule Bruton tyrosine kinase (BTK) inhibitors are in development for B cell malignancies and autoimmune disorders, each characterized by distinct potency and selectivity patterns. Herein we describe the pharmacologic characterization
Autor:
Bart Van Lith, Niels Hoogenboom, Gerjan de Bruin, J. Greg Slatter, Terry Podoll, Anouk de Jong, Maaike Emmelot-van Hoek, Tjeerd Barf, Joseph A. Ware, Allard Kaptein
Publikováno v:
Cancer Research. 79:2194-2194
Acalabrutinib is a potent and highly selective, oral covalent inhibitor of Bruton tyrosine kinase (BTK) that received accelerated approval for relapsed/refractory mantle cell lymphoma by the United States Food and Drug Administration in October 2017.
Publikováno v:
Nature climate change, 3(3), 244-248. Nature Publishing Group
Nature Climate Change, 3(3), 244-248. Nature Publishing Group
Nature Climate Change, 3(3), 244-248. Nature Publishing Group
Under changing climatic conditions, species need to adapt to their new environment. Genetic adaptation is crucial to prevent population extinction(1) but examples where climate change leads to genetic changes in wild populations have been few(2,3). T