Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Bart Van Lith"'
1
Akademický článek
Preclinical Evaluation of the Novel BTK Inhibitor Acalabrutinib in Canine Models of B-Cell Non-Hodgkin Lymphoma.
Autor: Bonnie K Harrington, Heather L Gardner, Raquel Izumi, Ahmed Hamdy, Wayne Rothbaum, Kevin R Coombes, Todd Covey, Allard Kaptein, Michael Gulrajani, Bart Van Lith, Cecile Krejsa, Christopher C Coss, Duncan S Russell, Xiaoli Zhang, Bridget K Urie, Cheryl A London, John C Byrd, Amy J Johnson, William C Kisseberth
Publikováno v: PLoS ONE, Vol 11, Iss 7, p e0159607 (2016)
Acalabrutinib (ACP-196) is a second-generation inhibitor of Bruton agammaglobulinemia tyrosine kinase (BTK) with increased target selectivity and potency compared to ibrutinib. In this study, we evaluated acalabrutinib in spontaneously occurring cani
Externí odkaz: https://doaj.org/article/885fb92964b3445a99b5a10f0adb8206
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2
Akademický článek
Partial recovery of the endothelial glycocalyx upon rosuvastatin therapy in patients with heterozygous familial hypercholesterolemia
Autor: Marijn C. Meuwese, Hans L. Mooij, Max Nieuwdorp, Bart van Lith, Roos Marck, Hans Vink, John J.P. Kastelein, Erik S.G. Stroes
Publikováno v: Journal of Lipid Research, Vol 50, Iss 1, Pp 148-153 (2009)
The endothelial glycocalyx has been shown to serve as a protective barrier between the flowing blood and the vessel wall in experimental models. The aim of this study was to evaluate whether hypercholesterolemia is associated with glycocalyx perturba
Externí odkaz: https://doaj.org/article/68856bf8580e4685a9eeca6a4e9b47a0
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3
Akademický článek
Experimental quantification of long distance dispersal potential of aquatic snails in the gut of migratory birds.
Autor: Casper H A van Leeuwen, Gerard van der Velde, Bart van Lith, Marcel Klaassen
Publikováno v: PLoS ONE, Vol 7, Iss 3, p e32292 (2012)
Many plant seeds and invertebrates can survive passage through the digestive system of birds, which may lead to long distance dispersal (endozoochory) in case of prolonged retention by moving vectors. Endozoochorous dispersal by waterbirds has nowada
Externí odkaz: https://doaj.org/article/74026e50bc054f9fb08c9e986940b602
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4
Identification and Characterization of ACP-5862, the Major Circulating Active Metabolite of Acalabrutinib: Both Are Potent and Selective Covalent Bruton Tyrosine Kinase Inhibitors
Autor: Terry, Podoll, Paul G, Pearson, Allard, Kaptein, Jerry, Evarts, Gerjan, de Bruin, Maaike, Emmelot-van Hoek, Anouk, de Jong, Bart, van Lith, Hao, Sun, Stephen, Byard, Adrian, Fretland, Niels, Hoogenboom, Tjeerd, Barf, J Greg, Slatter
Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 384:173-186
Acalabrutinib is a covalent Bruton tyrosine kinase (BTK) inhibitor approved for relapsed/refractory mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma. A major metabolite of acalabrutinib (M27, ACP-5862) was observed in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b51ca94d968a8dbd551ff1f2f6f4a3
https://doi.org/10.1124/jpet.122.001116
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5
Discovery of quinoline-based irreversible BTK inhibitors
Autor: Tjeerd Barf, Bart Van Lith, Todd Covey, Dennis Demont, Niels Hoogenboom, Bas van de Kar, Saskia Verkaik, Allard Kaptein, Maaike van Hoek, Gerjan de Bruin, Michael Gulrajani, Edwin de Zwart
Publikováno v: Bioorganicmedicinal chemistry letters. 30(14)
Bruton tyrosine kinase (BTK) is an important target in oncology and (auto)immunity. Various BTK inhibitors have been approved or are currently in clinical development. A novel BTK inhibitor series was developed starting with a quinazoline core. Movin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fecd469d561a9437604e8ef1f69fd8bf
https://pubmed.ncbi.nlm.nih.gov/32527559
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6
Timing manipulations reveal the lack of a causal link across timing of annual-cycle stages in a long-distance migrant
Autor: Iván de la Hera, Simone Meddle, Barbara M. Tomotani, Bart van Lith, Christiaan Both, Marcel E. Visser, Cynthia Y. M. J. G. Lange
Publikováno v: Journal of Experimental Biology, 222(17):jeb201467. The Company of Biologists Ltd
Tomotani, B, de la Hera, I, Lange, C Y M J G, van Lith, B, Meddle, S, Both, C & Visser, M E 2019, ' Timing manipulations reveal the lack of a causal link across annual cycle stages in a long distance migrant ', Journal of Experimental Biology . https://doi.org/10.1242/jeb.201467
The Journal of Experimental Biology, 222(17):jeb201467. COMPANY OF BIOLOGISTS LTD
Organisms need to time their annual-cycle stages, like breeding and migration, to occur at the right time of the year. Climate change has shifted the timing of annual-cycle stages at different rates, thereby tightening or lifting time constraints of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d629fc6e4a18eaab754606e07d643534
https://pure.knaw.nl/portal/en/publications/d4e83552-8298-436e-9ce0-1f8cea1e7149
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7
Fine-tuning of seasonal timing of breeding is regulated downstream in the underlying neuro-endocrine system in a small songbird
Autor: Veronika N. Laine, Heidi M. Viitaniemi, Kees van Oers, Marcel E. Visser, Phillip Gienapp, Ruben de Wit, Bart van Lith, Simone Meddle, Willem Kamphuis, Irene Verhagen, Samuel P. Caro, Tony D. Williams, Agata Pijl, A. Christa Mateman
Publikováno v: Journal of Experimental Biology
Journal of Experimental Biology, Cambridge University Press, 2019, 222 (17), pp.jeb202481. ⟨10.1242/jeb.202481⟩
Journal of Experimental Biology, The Company of Biologists, 2019, 222 (17), pp.jeb202481. ⟨10.1242/jeb.202481⟩
Journal of Experimental Biology, 222(17)
Journal of Experimental Biology, 222:jeb.202481. The Company of Biologists Ltd
Verhagen, I, Laine, V N, Mateman, AC, Pijl, A, de Wit, R, van Lith, B, Kamphuis, W, Viitaniemi, HM, Williams, T D, Caro, SP, Meddle, S, Gienapp, P, van Oers, K & Visser, M E 2019, ' Fine-tuning of seasonal timing of breeding is regulated downstream in the underlying neuro-endocrine system in a small song bird ', Journal of Experimental Biology . https://doi.org/10.1242/jeb.202481
Journal of Experimental Biology 222 (2019) 17
Journal of Experimental Biology, 2019, 222 (17), pp.jeb202481. ⟨10.1242/jeb.202481⟩
International audience; The timing of breeding is under selection in wild populations as a result of climate change, and understanding the underlying physiological processes mediating this timing provides insight into the potential rate of adaptation
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59149a8e0780136a29c78daea91d021f
https://hdl.handle.net/10411/5CQPHI
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8
Acalabrutinib (ACP-196): A Covalent Bruton Tyrosine Kinase Inhibitor with a Differentiated Selectivity and In Vivo Potency Profile
Autor: Dennis Demont, Roger G. Ulrich, Tjeerd Barf, Raquel Izumi, Allard Kaptein, Bart Van Lith, Edwin de Zwart, Michael Gulrajani, Todd Covey, Saskia Verkaik, Paul G. Pearson, Diana Mittag, Bas van de Kar, Fanny Krantz, Maaike van Hoek
Publikováno v: The Journal of pharmacology and experimental therapeutics. 363(2)
Several small-molecule Bruton tyrosine kinase (BTK) inhibitors are in development for B cell malignancies and autoimmune disorders, each characterized by distinct potency and selectivity patterns. Herein we describe the pharmacologic characterization
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2c688d3e7529373fba9017b6688ca0
https://pubmed.ncbi.nlm.nih.gov/28882879
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9
Abstract 2194: Preclinical pharmacological profiling of ACP-5862, the major metabolite of the covalent BTK inhibitor acalabrutinib, displays intrinsic BTK inhibitory activity
Autor: Bart Van Lith, Niels Hoogenboom, Gerjan de Bruin, J. Greg Slatter, Terry Podoll, Anouk de Jong, Maaike Emmelot-van Hoek, Tjeerd Barf, Joseph A. Ware, Allard Kaptein
Publikováno v: Cancer Research. 79:2194-2194
Acalabrutinib is a potent and highly selective, oral covalent inhibitor of Bruton tyrosine kinase (BTK) that received accelerated approval for relapsed/refractory mantle cell lymphoma by the United States Food and Drug Administration in October 2017.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8c0bab7eb2ca459c561fa2da3c05018f
https://doi.org/10.1158/1538-7445.am2019-2194
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10
Evolutionary response of the egg hatching date of a herbivorous insect under climate change
Autor: Leonard J. M. Holleman, Marcel E. Visser, Margriet van Asch, Lucia Salis, Bart van Lith
Publikováno v: Nature climate change, 3(3), 244-248. Nature Publishing Group
Nature Climate Change, 3(3), 244-248. Nature Publishing Group
Under changing climatic conditions, species need to adapt to their new environment. Genetic adaptation is crucial to prevent population extinction(1) but examples where climate change leads to genetic changes in wild populations have been few(2,3). T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1df72d91f23249f9bc32a686e34eeeee
https://doi.org/10.1038/nclimate1717
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