Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Bart Stoops"'
Autor:
Olivia Goethals, Suzanne J. F. Kaptein, Bart Kesteleyn, Jean-François Bonfanti, Liesbeth Van Wesenbeeck, Dorothée Bardiot, Ernst J. Verschoor, Babs E. Verstrepen, Zahra Fagrouch, J. Robert Putnak, Dominik Kiemel, Oliver Ackaert, Roel Straetemans, Sophie Lachau-Durand, Peggy Geluykens, Marjolein Crabbe, Kim Thys, Bart Stoops, Oliver Lenz, Lotke Tambuyzer, Sandra De Meyer, Kai Dallmeier, Michael K. McCracken, Gregory D. Gromowski, Wiriya Rutvisuttinunt, Richard G. Jarman, Nicos Karasavvas, Franck Touret, Gilles Querat, Xavier de Lamballerie, Laurent Chatel-Chaix, Gregg N. Milligan, David W. C. Beasley, Nigel Bourne, Alan D. T. Barrett, Arnaud Marchand, Tim H. M. Jonckers, Pierre Raboisson, Kenny Simmen, Patrick Chaltin, Ralf Bartenschlager, Willy M. Bogers, Johan Neyts, Marnix Van Loock
Publikováno v:
Nature. 615:678-686
Dengue is a major health threat and the number of symptomatic infections caused by the four dengue serotypes is estimated to be 96 million1 with annually around 10,000 deaths2. However, no antiviral drugs are available for the treatment or prophylaxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f8c0a4183f19bf33ac0d110d21b457f
https://doi.org/10.1038/s41586-023-05790-6
https://doi.org/10.1038/s41586-023-05790-6
Autor:
Sandrine Grosse, Abdellah Tahri, Pierre Raboisson, Yannis Houpis, Bart Stoops, Edgar Jacoby, Jean-Marc Neefs, Marnix Van Loock, Olivia Goethals, Peggy Geluykens, Jean-François Bonfanti, Tim H. M. Jonckers
Publikováno v:
ACS Medicinal Chemistry Letters. 13:1879-1884
In continuation of our efforts of finding novel nucleoside inhibitors for the treatment of viral diseases, we initiated a discovery research program aimed at identifying novel nucleos(t)ide inhibitors for emerging diseases like Dengue and Chikungunya
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a6a84c256df58b86b9b102ba666666
https://doi.org/10.1021/acsmedchemlett.2c00372
https://doi.org/10.1021/acsmedchemlett.2c00372
Autor:
Lindsey G. DeRatt, Bart Stoops, Paul Shaffer, Angela M. Lam, Christine Espiritu, Robert Vogel, Vincent Lau, Osvaldo A. Flores, Scott D. Kuduk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9be8563853e1080a3605e868030d58bb
https://doi.org/10.2139/ssrn.4437984
https://doi.org/10.2139/ssrn.4437984
Autor:
Scott D. Kuduk, Lindsey G. DeRatt, Bart Stoops, Paul Shaffer, Angela M. Lam, Christine Espiritu, Robert Vogel, Vincent Lau, Osvaldo A. Flores, George D. Hartman
Publikováno v:
Bioorganicmedicinal chemistry letters. 72
The HBV capsid core protein serves a number of important functions in the viral life cycle enabling chronic HBV infection to persist, and therefore is a promising drug target. Interfering with capsid assembly has shown efficacy in clinical trials wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec63428738a7d2b18279c29d843bf0c8
https://pubmed.ncbi.nlm.nih.gov/35644301
https://pubmed.ncbi.nlm.nih.gov/35644301
Autor:
Bart Rudolf Romanie Kesteleyn, Suzanne J.F. Kaptein, Xavier de Lamballerie, Kenny Simmen, Arnaud Marchand, Jean-François Bonfanti, Max Münster, Laurent Chatel-Chaix, Marjolein Crabbe, Johan Neyts, Marnix Van Loock, Kai Dallmeier, Gilles Querat, Franck Touret, Kim Thys, Olivia Goethals, Dorothée Bardiot, Tim H. M. Jonckers, Pierre Jean-Marie Bernard Raboisson, Peggy Geluykens, Dominik Kiemel, Patrick Chaltin, Bart Stoops, Ralf Bartenschlager
Dengue virus causes approximately 96 million symptomatic infections annually, manifesting as dengue fever or occasionally as severe dengue1,2. There are no antiviral agents available to prevent or treat dengue. Here, we describe a highly potent dengu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0f695891d12a95fecae329bcce0424
https://lirias.kuleuven.be/handle/123456789/683277
https://lirias.kuleuven.be/handle/123456789/683277
Autor:
Suzanne J F, Kaptein, Olivia, Goethals, Dominik, Kiemel, Arnaud, Marchand, Bart, Kesteleyn, Jean-François, Bonfanti, Dorothée, Bardiot, Bart, Stoops, Tim H M, Jonckers, Kai, Dallmeier, Peggy, Geluykens, Kim, Thys, Marjolein, Crabbe, Laurent, Chatel-Chaix, Max, Münster, Gilles, Querat, Franck, Touret, Xavier, de Lamballerie, Pierre, Raboisson, Kenny, Simmen, Patrick, Chaltin, Ralf, Bartenschlager, Marnix, Van Loock, Johan, Neyts
Publikováno v:
Nature. 598(7881)
Dengue virus causes approximately 96 million symptomatic infections annually, manifesting as dengue fever or occasionally as severe dengue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e4e1de640eac35dd21665b2d7bca5ffa
https://pubmed.ncbi.nlm.nih.gov/34697477
https://pubmed.ncbi.nlm.nih.gov/34697477
Autor:
Marc Nischang, Roger Sutmuller, Gustavo Gers-Huber, Annette Audigé, Duo Li, Mary-Aude Rochat, Stefan Baenziger, Ursula Hofer, Erika Schlaepfer, Stephan Regenass, Katie Amssoms, Bart Stoops, Anja Van Cauwenberge, Daniel Boden, Guenter Kraus, Roberto F Speck
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e38853 (2012)
BACKGROUND: Humanized mice generate a lymphoid system of human origin subsequent to transplantation of human CD34+ cells and thus are highly susceptible to HIV infection. Here we examined the efficacy of antiretroviral treatment (ART) when added to f
Externí odkaz:
https://doaj.org/article/a0eef2ffb6d34bd1a4372d297ec17cbd
Autor:
Mari Luz Rosauro, Kris Van Dijck, Gregory Fanning, David McGowan, Sara M. Pérez Benedicto, Bart Stoops, Pierre Jean-Marie Bernard Raboisson, Bertrand Van Schoubroeck, Wendy Mostmans, Annick Scholliers, Tine Thoné, Frederik Pauwels, Mourad Daoubi Khamlichi, Vineet Pande, Tim H. M. Jonckers, Florence Herschke, Helen Horton
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:3216-3221
In a continuing effort to discover novel TLR agonists, herein we report on the discovery and structure-activity relationship of novel tetrahydropyridopyrimidine TLR 7/8 agonists. Optimization of this series towards dual agonist activity and a high cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::672c8e93b24a0e8e1a7a0d8161208345
https://doi.org/10.1016/j.bmcl.2018.08.015
https://doi.org/10.1016/j.bmcl.2018.08.015
Autor:
Werner Embrechts, Florence Herschke, Frederik Pauwels, Bart Stoops, Stefaan Last, Serge Pieters, Vineet Pande, Geert Pille, Katie Amssoms, Ilham Smyej, Deborah Dhuyvetter, Annick Scholliers, Wendy Mostmans, Kris Van Dijck, Bertrand Van Schoubroeck, Tine Thone, Dorien De Pooter, Gregory Fanning, Tim H. M. Jonckers, Helen Horton, Pierre Raboisson, David McGowan
Publikováno v:
Journal of Medicinal Chemistry. 61:6236-6246
A novel series of 2,4-diaminoquinazolines was identified as potent dual Toll-like receptor (TLR) 7 and 8 agonists with reduced off-target activity. The stereochemistry of the amino alcohol was found to influence the TLR7/8 selectivity with the ( R) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a3b7db1da80bbf55cd9acce1f8bb47
https://doi.org/10.1021/acs.jmedchem.8b00643
https://doi.org/10.1021/acs.jmedchem.8b00643
Autor:
Serge Pieters, David McGowan, Florence Herschke, Frederik Pauwels, Bart Stoops, Stefaan Last, Werner Embrechts, Annick Scholliers, Wendy Mostmans, Kris Van Dijck, Bertrand Van Schoubroeck, Tine Thoné, Dorien De Pooter, Gregory Fanning, Mari Luz Rosauro, Mourad Daoubi Khamlichi, Ioannis Houpis, Eric Arnoult, Tim H.M. Jonckers, Pierre Raboisson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 28:711-719
The discovery of a novel series of highly potent quinazoline TLR 7/8 agonists is described. The synthesis and structure-activity relationship is presented. Structural requirements and optimization of this series toward TLR 7 selectivity afforded the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecb247545d952c5e2d61547d1061dea6
https://doi.org/10.1016/j.bmcl.2018.01.014
https://doi.org/10.1016/j.bmcl.2018.01.014