Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Bart Smets"'
Autor:
Abolfazl Doostparast Torshizi, Dongnhu T. Truong, Liping Hou, Bart Smets, Christopher D. Whelan, Shuwei Li
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Parkinson’s disease is highly heterogeneous across disease symptoms, clinical manifestations and progression trajectories, hampering the identification of therapeutic targets. Despite knowledge gleaned from genetics analysis, dysregulated
Externí odkaz:
https://doaj.org/article/af48a3f67403494c92d6384ce4e6936d
Autor:
Karen Y. He, Ekaterina A. Khramtsova, Alfredo Cabrera-Socorro, Yanfei Zhang, Shuwei Li, Brice A. J. Sarver, Bart Smets, Qingqin S. Li, Louis De Muynck, Antonio R. Parrado, Simon Lovestone, Mary Helen Black
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-4 (2023)
Externí odkaz:
https://doaj.org/article/963aba3c0f6644fe9e74f893f8ec0328
Autor:
Sophia Cammaerts, Mojca Strazisar, Bart Smets, Sarah Weckhuysen, Annelie Nordin, Peter De Jonghe, Rolf Adolfsson, Peter De Rijk, Jurgen Del Favero
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144428 (2015)
As regulators of gene expression, microRNAs (miRNAs) are likely to play an important role in the development of disease. In this study we present a large-scale strategy to identify miRNAs with a role in the regulation of neuronal processes. Thereby w
Externí odkaz:
https://doaj.org/article/5421c2f777ad41dfa992b9c6bea8db3d
Autor:
William Sproviero, Upamanyu Ghose, Laura M Winchester, Marco Fernandes, Danielle Newby, Daisy Sproviero, Najaf Amin, Bart Smets, Karen Y. He, Ekaterina A. Khramtsova, Parth Patel, Brice A. J. Sarver, Trevor Howe, Mary Helen Black, Cornelia van Duijn, Alejo Nevado-Holgado
We performed a genome-wide association study of 143,067 highly polymorphic short tandem repeats (STRs) with MRI brain grey matter volumes (GMVs) on 10,702 UK Biobank (UKB) participants, including 8,751 in the discovery stage and 1,701 in the replicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::da95e9c8fe334221e199023944908ba3
https://doi.org/10.1101/2023.02.27.23286496
https://doi.org/10.1101/2023.02.27.23286496
Autor:
Karen Y. He, Ekaterina A. Khramtsova, Alfredo Cabrera-Socorro, Yanfei Zhang, Shuwei Li, Brice A. J. Sarver, Bart Smets, Qingqin S. Li, Louis De Muynck, Antonio R. Parrado, Simon Lovestone, Mary Helen Black
ImportanceA few case studies have reported the APOE Christchurch (APOECh) variant to confer protective effects for Alzheimer’s disease (AD) and a higher risk of premature cardiovascular disease (CVD). However, these studies primarily focused on a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8150e221f6b14586af35050c753501b0
https://doi.org/10.1101/2022.12.05.22283048
https://doi.org/10.1101/2022.12.05.22283048
Publikováno v:
Pure TUe
arXiv, 2019:1902.08145. Cornell University Library
arXiv, 2019:1902.08145. Cornell University Library
Total variation regularization and total variation flows (TVF) have been widely applied for image enhancement and denoising. To include a generic preservation of crossing curvilinear structures in TVF we lift images to the homogeneous space $M = \mat
Autor:
Yusuf A. Hannun, Joris Winderickx, Pepijn De Snijder, Dirk De Vos, Jolanta Idkowiak-Baldys, Sabina Accardo, Jacek Bielawski, Ruben Ghillebert, Bart Smets, Karin Thevissen, Erwin Swinnen, Bruno P. A. Cammue, Tobias Wilms
Publikováno v:
Molecular Biology of the Cell
Sphingolipids play crucial roles in the determination of growth and survival of eukaryotic cells. The budding yeast protein kinase Sch9 is not only an effector, but also a regulator of sphingolipid metabolism. This new function provides a crucial lin
Autor:
Jean Feyen, L. Lepescheux, Thierry Christophe, Luc Juliaan Corina Van Rompaey, Luc Nelles, Reginald Brys, Steve De Vos, Nick Vandeghinste, Gerben van ’t Klooster, Ellen van der Aar, Bart Smets, Stephen Robert Fletcher, Philippe Clément-Lacroix, Béatrice Vayssière, R Galien, Katja Conrath, Christel Jeanne Marie Menet
Publikováno v:
The Journal of Immunology. 191:3568-3577
The JAKs receive continued interest as therapeutic targets for autoimmune, inflammatory, and oncological diseases. JAKs play critical roles in the development and biology of the hematopoietic system, as evidenced by mouse and human genetics. JAK1 is
Publikováno v:
Biochemical Journal. 434:243-251
When starved of P(i), yeast cells activate the PHO signalling pathway, wherein the Pho4 transcription factor mediates expression of genes involved in P(i) acquisition, such as PHO84, encoding the high-affinity H(+)/P(i) symporter. In contrast, transc
Autor:
Joris Winderickx, Didac Carmona-Gutierrez, Cungui Mao, Bruno P. A. Cammue, Piotr Zabrocki, Isabelle François, Frank Madeo, Gilmer Govaert, Bart Smets, An M. Aerts, Karin Thevissen
Publikováno v:
Cellular and Molecular Life Sciences. 65:1933-1942
Saccharomyces cerevisiae dihydroceramidase Ydc1p hydrolyzes ceramide, resulting in accumulation of free long-chain bases and their phosphates. Yeast mutants lacking YDC1 are characterized by increased chronological lifespan. Moreover, we found YDC1 u