Zobrazeno 1 - 10
of 229
pro vyhledávání: '"Bart O. Williams"'
Autor:
Cassandra R. Diegel, Ina Kramer, Charles Moes, Gabrielle E. Foxa, Mitchell J. McDonald, Zachary B. Madaj, Sabine Guth, Jun Liu, Jennifer L. Harris, Michaela Kneissel, Bart O. Williams
Publikováno v:
Bone Research, Vol 11, Iss 1, Pp 1-12 (2023)
Abstract Proper regulation of Wnt signaling is critical for normal bone development and homeostasis. Mutations in several Wnt signaling components, which increase the activity of the pathway in the skeleton, cause high bone mass in human subjects and
Externí odkaz:
https://doaj.org/article/61eebd1859c547e987869a53f524eaf5
Autor:
Kevin A. Maupin, Cassandra R. Diegel, Payton D. Stevens, Daniel Dick, VAI Vivarium and Transgenic Core, Bart O. Williams
Publikováno v:
FEBS Open Bio, Vol 12, Iss 10, Pp 1717-1728 (2022)
We previously observed that genomic loss of galectin‐3 (Gal‐3; encoded by Lgals3) in mice has a significant protective effect on age‐related bone loss. Gal‐3 has both intracellular and extracellular functionality, and we wanted to assess whet
Externí odkaz:
https://doaj.org/article/874c659405224149baacd2786c3095d3
Autor:
Megan N. Michalski, Bart O. Williams
Publikováno v:
Biomolecules, Vol 13, Iss 9, p 1311 (2023)
The ability to create genetically engineered mouse models (GEMMs) has exponentially increased our understanding of many areas of biology. Musculoskeletal biology is no exception. In this review, we will first discuss the historical development of GEM
Externí odkaz:
https://doaj.org/article/da31df96274545a49476f72a98dbd92b
Autor:
Jianshuang Li, Di Lu, Hong Dou, Huadie Liu, Kevin Weaver, Wenjun Wang, Jiada Li, Edward T.H. Yeh, Bart O. Williams, Ling Zheng, Tao Yang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Osteochondroprogenitors are essential cells for skeletal development and homeostasis. Here the authors show that the desumoylase SENP6 suppresses p53 activity by desumoylating and stabilising TRIM28, and that SENP6 ablation leads to skeletal abnormal
Externí odkaz:
https://doaj.org/article/3565532495544c8b84b47ed37cbda2a1
Autor:
Alana M. Chin, Yu-Hwai Tsai, Stacy R. Finkbeiner, Melinda S. Nagy, Emily M. Walker, Nicole J. Ethen, Bart O. Williams, Michele A. Battle, Jason R. Spence
Publikováno v:
Stem Cell Reports, Vol 7, Iss 5, Pp 826-839 (2016)
Much of our understanding about how intestinal stem and progenitor cells are regulated comes from studying the late fetal stages of development and the adult intestine. In this light, little is known about intestine development prior to the formation
Externí odkaz:
https://doaj.org/article/ff5a3106f35549bfb94f5efc07de0797
Autor:
Alexis Bergsma, Sourik S. Ganguly, Mollie E. Wiegand, Daniel Dick, Bart O. Williams, Cindy K. Miranti
Publikováno v:
Bone Reports, Vol 10, Iss , Pp - (2019)
We used a myeloid-specific Cre to conditionally delete CD82 in mouse osteoclasts and their precursors. In contrast to global loss of CD82 (gKO), conditional loss of CD82 (cKO) in osteoclasts does not affect cortical bone, osteoblasts, or adipocytes.
Externí odkaz:
https://doaj.org/article/2858f30c3eae41ec8b955fbd6c99fb96
Autor:
Kenneth C. Valkenburg, Carrie R. Graveel, Cassandra R. Zylstra-Diegel, Zhendong Zhong, Bart O. Williams
Publikováno v:
Cancers, Vol 3, Iss 2, Pp 2050-2079 (2011)
The ability of Wnt ligands to initiate a signaling cascade that results in cytoplasmic stabilization of, and nuclear localization of, β-catenin underlies their ability to regulate progenitor cell differentiation. In this review, we will summarize th
Externí odkaz:
https://doaj.org/article/04c8a43aa2e94c6b9f79b0ec8cd07b89
Autor:
Jianshuang Li, Di Lu, Hong Dou, Huadie Liu, Kevin Weaver, Wenjun Wang, Jiada Li, Edward T. H. Yeh, Bart O. Williams, Ling Zheng, Tao Yang
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
In the originally published version of this Article, the positions of the final two authors in the author list were inadvertently inverted during the production process. This error has now been corrected in both the PDF and HTML versions of the Artic
Externí odkaz:
https://doaj.org/article/b26e8546a48141dcb25a376acca2e618
Publikováno v:
Prostate Cancer, Vol 2011 (2011)
The development and optimization of high-throughput screening methods has identified a multitude of genetic changes associated with human disease. The use of immunodeficient and genetically engineered mouse models that mimic the human disease has bee
Externí odkaz:
https://doaj.org/article/bb8c39c4f5b34875b8d027677e9c8f4a
Autor:
James J. Mason, Bart O. Williams
Publikováno v:
Journal of Osteoporosis, Vol 2010 (2010)
The study of rare human genetic disorders has often led to some of the most significant advances in biomedical research. One such example was the body of work that resulted in the identification of the Low Density Lipoprotein-Related Protein (LRP5) a
Externí odkaz:
https://doaj.org/article/0dd6ed6177a944f1a0bd82cab3b739d2