Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Bart Nijmeijer"'
Autor:
Nadine Bachtler, Sandra Torres, Cristina Ortiz, Robert Schierwagen, Olaf Tyc, Christoph Hieber, Marie-Luise Berres, Caroline Meier, Nico Kraus, Stefan Zeuzem, Bart Nijmeijer, Sebas Pronk, Jonel Trebicka, Sabine Klein
Publikováno v:
PLoS ONE, Vol 18, Iss 1, p e0270288 (2023)
BackgroundThe Rho-kinase ROCK II plays a major role in the activation of hepatic stellate cells (HSC), which are the key profibrotic and contractile cells contributing to the development of chronic liver disease. Inhibition of ROCK II ultimately bloc
Externí odkaz:
https://doaj.org/article/4c3545d1400a45c989d504352b4d8006
Autor:
Elisabeth A. Spronck, Ying Poi Liu, Jacek Lubelski, Erich Ehlert, Sander Gielen, Paula Montenegro-Miranda, Martin de Haan, Bart Nijmeijer, Valerie Ferreira, Harald Petry, Sander J. van Deventer
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 15, Iss , Pp 221-231 (2019)
Gene therapy for severe hemophilia B is advancing and offers sustained disease amelioration with a single treatment. We have reported the efficacy and safety of AMT-060, an investigational gene therapy comprising an adeno-associated virus serotype 5
Externí odkaz:
https://doaj.org/article/f68597eceef64b579989937b741d7460
Autor:
Joey A. Muns, Eugen Merkul, Hendrik-Jan Houthoff, Niels J. Sijbrandi, Gerro van Rheenen, Jan Reedijk, Bart Nijmeijer, Guus A.M.S. van Dongen
Publikováno v:
Merkul, E, Muns, J A, Sijbrandi, N J, Houthoff, H-J, Nijmeijer, B, van Rheenen, G, Reedijk, J & van Dongen, G A M S 2021, ' An Efficient Conjugation Approach for Coupling Drugs to Native Antibodies via the PtII Linker Lx for Improved Manufacturability of Antibody–Drug Conjugates ', Angewandte Chemie International Edition in English, vol. 60, no. 6, pp. 3008-3015 . https://doi.org/10.1002/anie.202011593
Angewandte Chemie International Edition
Angewandte Chemie International Edition, 60(6), 3008-3015. WILEY-V C H VERLAG GMBH
Angewandte Chemie International Edition in English, 60(6), 3008-3015. John Wiley and Sons Ltd
Angewandte Chemie (International Ed. in English)
Angewandte Chemie International Edition
Angewandte Chemie International Edition, 60(6), 3008-3015. WILEY-V C H VERLAG GMBH
Angewandte Chemie International Edition in English, 60(6), 3008-3015. John Wiley and Sons Ltd
Angewandte Chemie (International Ed. in English)
The PtII linker [ethylenediamineplatinum(II)]2+, coined Lx, has emerged as a novel non‐conventional approach to antibody–drug conjugates (ADCs) and has shown its potential in preclinical in vitro and in vivo benchmark studies. A crucial improveme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bbda0225d8319753fbb07d6bc01f549
https://research.vumc.nl/en/publications/04da0987-4be7-4db3-9b91-29c459e4d5b0
https://research.vumc.nl/en/publications/04da0987-4be7-4db3-9b91-29c459e4d5b0
Autor:
Ibrahim Aydin, Guus A.M.S. van Dongen, Joey A. Muns, Niels J. Sijbrandi, Bart Nijmeijer, Eugen Merkul, Hendrik-Jan Houthoff, Kevin Adamzek
Publikováno v:
Expert Opinion on Drug Delivery, 16(8), 783-793. Taylor and Francis Ltd.
Merkul, E, Sijbrandi, N J, Muns, J A, Aydin, I, Adamzek, K, Houthoff, H-J, Nijmeijer, B & van Dongen, G A M S 2019, ' First platinum(II)-based metal-organic linker technology (Lx®) for a plug-and-play development of antibody-drug conjugates (ADCs) ', Expert Opinion on Drug Delivery, vol. 16, no. 8, pp. 783-793 . https://doi.org/10.1080/17425247.2019.1645118
Merkul, E, Sijbrandi, N J, Muns, J A, Aydin, I, Adamzek, K, Houthoff, H-J, Nijmeijer, B & van Dongen, G A M S 2019, ' First platinum(II)-based metal-organic linker technology (Lx®) for a plug-and-play development of antibody-drug conjugates (ADCs) ', Expert Opinion on Drug Delivery, vol. 16, no. 8, pp. 783-793 . https://doi.org/10.1080/17425247.2019.1645118
Introduction: Compared to the antibody and drug components of an ADC, the linker part has been somewhat neglected. However, its importance for the reduction of failures in ADC approvals is increasingly recognized. Next of being a stable glue between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6a7c15771297f9dfaa67134234a7c18
https://research.vumc.nl/en/publications/49b777ab-31a5-487a-a503-b8c4848deb25
https://research.vumc.nl/en/publications/49b777ab-31a5-487a-a503-b8c4848deb25
Autor:
Niels J. Sijbrandi, Guus A.M.S. van Dongen, Gerro van Rheenen, Joey A. Muns, Jan Reedijk, Eugen Merkul, Bart Nijmeijer, Hendrik-Jan Houthoff
Publikováno v:
Angewandte Chemie. 133:2741-2741
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3091c7acf781da4da61ebfa476b9b13c
https://doi.org/10.1002/ange.202016966
https://doi.org/10.1002/ange.202016966