Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Bart L. Staker"'
Autor:
Diego Rodríguez-Hernández, Kamalakannan Vijayan, Rachael Zigweid, Michael K. Fenwick, Banumathi Sankaran, Wanlapa Roobsoong, Jetsumon Sattabongkot, Elizabeth K. K. Glennon, Peter J. Myler, Per Sunnerhagen, Bart L. Staker, Alexis Kaushansky, Morten Grøtli
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract Drugs targeting multiple stages of the Plasmodium vivax life cycle are needed to reduce the health and economic burdens caused by malaria worldwide. N-myristoyltransferase (NMT) is an essential eukaryotic enzyme and a validated drug target f
Externí odkaz:
https://doaj.org/article/e6b4e2ed37a24eb3abab00e4f5cd5476
Autor:
Spencer O. Moen, Thomas E. Edwards, David M. Dranow, Matthew C. Clifton, Banumathi Sankaran, Wesley C. Van Voorhis, Amit Sharma, Colin Manoil, Bart L. Staker, Peter J. Myler, Donald D. Lorimer
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract Aminoacyl-tRNA synthetases (aaRSs) charge tRNAs with their cognate amino acid, an essential precursor step to loading of charged tRNAs onto the ribosome and addition of the amino acid to the growing polypeptide chain during protein synthesis
Externí odkaz:
https://doaj.org/article/514875561f484af5b0d951c78c79f7d3
Autor:
Joseph J. Gillespie, Isabelle Q. H. Phan, Holger Scheib, Sandhya Subramanian, Thomas E. Edwards, Stephanie S. Lehman, Hanna Piitulainen, M. Sayeedur Rahman, Kristen E. Rennoll-Bankert, Bart L. Staker, Suvi Taira, Robin Stacy, Peter J. Myler, Abdu F. Azad, Arto T. Pulliainen
Publikováno v:
mBio, Vol 6, Iss 6 (2015)
ABSTRACT Prokaryotes use type IV secretion systems (T4SSs) to translocate substrates (e.g., nucleoprotein, DNA, and protein) and/or elaborate surface structures (i.e., pili or adhesins). Bacterial genomes may encode multiple T4SSs, e.g., there are th
Externí odkaz:
https://doaj.org/article/eddba446b9474c58833850283358d59e
Publikováno v:
ACS Pharmacology & Translational Science. 6:578-586
Autor:
Imani Porter, Trinity Neal, Zion Walker, Dylan Hayes, Kayla Fowler, Nyah Billups, Anais Rhoades, Christian Smith, Kaelyn Smith, Bart L. Staker, David M. Dranow, Stephen J. Mayclin, Sandhya Subramanian, Thomas E. Edwards, Peter J. Myler, Oluwatoyin A. Asojo
Publikováno v:
Acta Crystallographica. Section F, Structural Biology Communications
Crystal structures of FolM alternative dihydrofolate reductase 1 from Brucella suis and Brucella canis reveal prototypical NADPH-dependent short-chain reductases with structural similarity to protozoan pteridine reductases that are potential drug tar
Crystal structure of a putative short-chain dehydrogenase/reductase from Paraburkholderia xenovorans
Autor:
Jaysón Davidson, Kyndall Nicholas, Jeremy Young, Deborah G. Conrady, Stephen Mayclin, Sandhya Subramanian, Bart L. Staker, Peter J. Myler, Oluwatoyin A. Asojo
Publikováno v:
Acta Crystallographica. Section F, Structural Biology Communications
The high-resolution structure of a putative short-chain reductase from the commercially important bacterium Paraburkholderia xenovorans is reported. P. xenovorans degrades organic wastes such as polychlorinated biphenyls.
Paraburkholderia xenovo
Paraburkholderia xenovo
Autor:
Diego Rodríguez-Hernández, Kamalakannan Vijayan, Rachael Zigweid, Michael K. Fenwick, Banumathi Sankaran, Wanlapa Roobsoong, Jetsumon Sattabongkot, Elizabeth K.K. Glennon, Peter J. Myler, Per Sunnerhagen, Bart L. Staker, Alexis Kaushansky, Morten Grøtli
New drugs targeting multiple stages of the malaria-causing parasite,Plasmodium, are needed to reduce and eliminate malaria worldwide.N-Myristoyltransferase (NMT) is an essential eukaryotic enzyme, and a validated chemically tractable drug target for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::72dfc915e3dbc50d6fca725023103ca3
https://doi.org/10.1101/2023.01.27.525941
https://doi.org/10.1101/2023.01.27.525941
Autor:
Bin Xie, Allison Maker, Andrew V. Priest, David M. Dranow, Jenny N. Phan, Thomas E. Edwards, Bart L. Staker, Peter J. Myler, Barry M. Gumbiner, Sanjeevi Sivasankar
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 32
E-cadherin (Ecad) is an essential cell-cell adhesion protein with tumor suppression properties. The adhesive state of Ecad can be modified by the monoclonal antibody 19A11, which has potential applications in reducing cancer metastasis. Using x-ray c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::176a9800b598dcbe51c51bc3fac70bde
https://escholarship.org/uc/item/1mq1h63t
https://escholarship.org/uc/item/1mq1h63t
Autor:
Shalev Gihaz, Peter Gareiss, Jae‐Yeon Choi, Isaline Renard, Anasuya Chattopadhyay Pal, Yulia Surovsteva, Joy E. Chiu, Jose Thekkiniath, Mark Plummer, William Hungerford, Micaela L. Montgomery, Alanah Hosford, Emily M. Adams, Jorge D. Lightfoot, David Fox, Kayode K. Ojo, Bart L. Staker, Kevin Fuller, Choukri Ben Mamoun
Publikováno v:
The FASEB Journal. 36
Autor:
Thomas E. Edwards, Sunny Zhang, Justas V Rodarte, Donald D. Lorimer, Bart L. Staker, Krystle J. McLaughlin, Jan Abendroth, Peter J. Myler
Publikováno v:
Acta Crystallogr F Struct Biol Commun
Rickettsia felis, a Gram-negative bacterium that causes spotted fever, is of increasing interest as an emerging human pathogen. R. felis and several other Rickettsia strains are classed as National Institute of Allergy and Infectious Diseases priorit