Zobrazeno 1 - 10
of 358
pro vyhledávání: '"Bart L Haagmans"'
Autor:
Maitrayee Chatterjee, Liane Z X Huang, Anna Z Mykytyn, Chunyan Wang, Mart M Lamers, Bart Westendorp, Richard W Wubbolts, Jos P M van Putten, Berend-Jan Bosch, Bart L Haagmans, Karin Strijbis
Publikováno v:
PLoS Pathogens, Vol 19, Iss 8, p e1011571 (2023)
Mucins play an essential role in protecting the respiratory tract against microbial infections while also acting as binding sites for bacterial and viral adhesins. The heavily O-glycosylated gel-forming mucins MUC5AC and MUC5B eliminate pathogens by
Externí odkaz:
https://doaj.org/article/5c8ab95199664948ba87d8d4e698b857
Autor:
Ilhan Tomris, Kim M Bouwman, Youri Adolfs, Danny Noack, Roosmarijn van der Woude, Gius Kerster, Sander Herfst, Rogier W Sanders, Marit J van Gils, Geert-Jan Boons, Bart L Haagmans, R Jeroen Pasterkamp, Barry Rockx, Robert P de Vries
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010340 (2022)
SARS-CoV-2 attaches to angiotensin-converting enzyme 2 (ACE2) to gain entry into cells after which the spike protein is cleaved by the transmembrane serine protease 2 (TMPRSS2) to facilitate viral-host membrane fusion. ACE2 and TMPRSS2 expression pro
Externí odkaz:
https://doaj.org/article/dcc13b37132847f5b458e98303166130
Autor:
Mart M Lamers, Anna Z Mykytyn, Tim I Breugem, Yiquan Wang, Douglas C Wu, Samra Riesebosch, Petra B van den Doel, Debby Schipper, Theo Bestebroer, Nicholas C Wu, Bart L Haagmans
Publikováno v:
eLife, Vol 10 (2021)
Virus propagation methods generally use transformed cell lines to grow viruses from clinical specimens, which may force viruses to rapidly adapt to cell culture conditions, a process facilitated by high viral mutation rates. Upon propagation in VeroE
Externí odkaz:
https://doaj.org/article/3d0c2b13478f4404ae22e956acd8b062
Autor:
Kim M Bouwman, Ilhan Tomris, Hannah L Turner, Roosmarijn van der Woude, Tatiana M Shamorkina, Gerlof P Bosman, Barry Rockx, Sander Herfst, Joost Snijder, Bart L Haagmans, Andrew B Ward, Geert-Jan Boons, Robert P de Vries
Publikováno v:
PLoS Pathogens, Vol 17, Iss 2, p e1009282 (2021)
Receptor binding studies on sarbecoviruses would benefit from an available toolkit of recombinant spike proteins, or domains thereof, that recapitulate receptor binding properties of native viruses. We hypothesized that trimeric Receptor Binding Doma
Externí odkaz:
https://doaj.org/article/0b7db8afaba94b17b22fbc8758f4ac2d
Autor:
Karel Bezstarosti, Mart M Lamers, Wouter A S Doff, Peter C Wever, Khoa T D Thai, Jeroen J A van Kampen, Bart L Haagmans, Jeroen A A Demmers
Publikováno v:
PLoS ONE, Vol 16, Iss 11, p e0259165 (2021)
The rapid, sensitive and specific detection of SARS-CoV-2 is critical in responding to the current COVID-19 outbreak. In this proof-of-concept study, we explored the potential of targeted mass spectrometry (MS) based proteomics for the detection of S
Externí odkaz:
https://doaj.org/article/077cab94180b48079fe6484c8ab0ec50
Autor:
Anna Z Mykytyn, Tim I Breugem, Samra Riesebosch, Debby Schipper, Petra B van den Doel, Robbert J Rottier, Mart M Lamers, Bart L Haagmans
Publikováno v:
eLife, Vol 10 (2021)
Coronavirus entry is mediated by the spike protein that binds the receptor and mediates fusion after cleavage by host proteases. The proteases that mediate entry differ between cell lines, and it is currently unclear which proteases are relevant in v
Externí odkaz:
https://doaj.org/article/bff5e7cfb4864de5a79908ccfb16e14b
Publikováno v:
PLoS ONE, Vol 12, Iss 6, p e0179064 (2017)
Hepatitis C virus (HCV) is genetically highly divergent and classified in seven major genotypes and approximately hundred subtypes. These genotypes/subtypes have different geographic distribution and response to antiviral therapy. In Ethiopia, howeve
Externí odkaz:
https://doaj.org/article/1ec1477fd12b4b4fac81cbc1161e3386
Coronavirus cell entry occurs through the endo-/lysosomal pathway in a proteolysis-dependent manner.
Autor:
Christine Burkard, Monique H Verheije, Oliver Wicht, Sander I van Kasteren, Frank J van Kuppeveld, Bart L Haagmans, Lucas Pelkmans, Peter J M Rottier, Berend Jan Bosch, Cornelis A M de Haan
Publikováno v:
PLoS Pathogens, Vol 10, Iss 11, p e1004502 (2014)
Enveloped viruses need to fuse with a host cell membrane in order to deliver their genome into the host cell. While some viruses fuse with the plasma membrane, many viruses are endocytosed prior to fusion. Specific cues in the endosomal microenvironm
Externí odkaz:
https://doaj.org/article/1d8f17335c7942ac9824e89e4be9d62e
Autor:
Anita C Schürch, Debby Schipper, Maarten A Bijl, Jim Dau, Kimberlee B Beckmen, Claudia M E Schapendonk, V Stalin Raj, Albert D M E Osterhaus, Bart L Haagmans, Morten Tryland, Saskia L Smits
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e105227 (2014)
Pathogen surveillance in animals does not provide a sufficient level of vigilance because it is generally confined to surveillance of pathogens with known economic impact in domestic animals and practically nonexistent in wildlife species. As most (r
Externí odkaz:
https://doaj.org/article/3f74ff3f943545a7b1dd10b83f1d1b53
Autor:
Werner J D Ouwendijk, Ravi Mahalingam, Rik L de Swart, Bart L Haagmans, Geert van Amerongen, Sarah Getu, Don Gilden, Albert D M E Osterhaus, Georges M G M Verjans
Publikováno v:
PLoS Pathogens, Vol 9, Iss 5, p e1003368 (2013)
Varicella-zoster virus (VZV) causes varicella, establishes a life-long latent infection of ganglia and reactivates to cause herpes zoster. The cell types that transport VZV from the respiratory tract to skin and ganglia during primary infection are u
Externí odkaz:
https://doaj.org/article/9ef5e8b8b3264166ab28287ee248d2c4